Protein Alignment MAP4K5 and map4k5

DIOPT Version :10

• Sequence 1: XP_047286846.1
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 863
• Species: Homo sapiens
• Sequence 2: XP_021336201.1
• Gene: map4k5 / 334565
• ZFINID: ZDB-GENE-030131-6497
• Length: 894
• Species: Danio rerio
• Alignment Length: 917
• Identity: 670/917 - (73%)
• Similarity: 748/917 - (81%)
• Gaps: 77/917 - (8%)

Human     1 MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQE 65
            |:...|...:|.|||||.|:||:|||||||||||||||.:.|||||||||||||||||||:||||
Zfish     1 MDPLARSGGEIQRRNPQHDFELIQRVGSGTYGDVYKARKISTGELAAVKIIKLEPGDDFSIIQQE 65

Human    66 IFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAY 130
            |||||||.|.||||||||||.||||||||||||||||||||||||||||||||||||||||||.|
Zfish    66 IFMVKECTHHNIVAYFGSYLCREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLGY 130

Human   131 LHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGY 195
            ||:|||||||||||||||||:|||||||||||||||||:||||||||||||||||||||||||||
Zfish   131 LHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATMAKRKSFIGTPYWMAPEVAAVEKNGGY 195

Human   196 NQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTK 260
            |.||||||||||:|||.|||||||||||||||||||||||||||||||||||:.||||||::|||
Zfish   196 NHLCDIWAVGITSIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSTAFHNFVKLSLTK 260

Human   261 NPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNH-AHYTEADDDDFEPHAIIRHTIRST 324
            |||:|||||::|:|.||.|.||:|.||:|||||:|||||| :|:::.|:|||||.| .|||||||
Zfish   261 NPKRRPTAEKMLSHLFVGQTGLTRRLALELLDKMNNPDNHQSHFSQGDEDDFEPLA-ERHTIRST 324

Human   325 -NRNARAERTASEINYQPFEMLSLYIPVIYFAVDKLQFEPPLRKETEARDEMGLSSDPNFMLQWN 388
             :|:||||||.|:||:                 |||||||||||||||..||.::.|.:|...|:
Zfish   325 HSRSARAERTQSQINF-----------------DKLQFEPPLRKETEASAEMDVTKDNDFPSPWS 372

Human   389 PFVDGANTGKSTSK----------------------------RAIPPPLPPKP--RISSYPEDNF 423
            ||.||..|.:|..|                            :.:||||||||  ..||...|.|
Zfish   373 PFTDGPITSRSLLKSVEEELFIRGHLAPLEDAFEDVDLSTLGKGVPPPLPPKPSQARSSSVSDEF 437

Human   424 PDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAE----------TSSIG----------NGDG 468
            ...:...|::..|.|::....:.||||:|..|..||          .||.|          :.||
Zfish   438 GLADGCQTVRRFPGSDNGPMPVARRQSTPERGSNAEHTHSDYLSVSVSSPGLLSHTTDHEEDSDG 502

Human   469 ISKLMSENTEGSAQAPQLPRKKDKRDFP--KPAINGLPPTPKVLMGACFSKVFDGCPLKINCATS 531
                 |.|.:.|...|..|::|:::|||  |||||||||||||||||||||||||||||||||||
Zfish   503 -----SVNGDVSKSPPGRPQRKERKDFPVSKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATS 562

Human   532 WIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHN 596
            ||||:|||||:|||||||||||||||||||||||||||:|||||:|||.||||||||||||||||
Zfish   563 WIHPETKDQYLIFGTEDGIYTLNLNELHEATMEQLFPRRCTWLYIINNNLMSLSEGKTFQLYSHN 627

Human   597 LIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQS 661
            ||.|||..:|||||....||||||:||||:|||||||||||||||||||||||||||||||||||
Zfish   628 LIGLFEQLRKPGLATQFHTHRFPDKILPRRFALTTKIPDTKGCHKCCIVRNPYTGHKYLCGALQS 692

Human   662 GIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINL 726
            ||||||||||||:||||||||||:||||.||||||:||||||:||||:|:|:|..|||:|:||||
Zfish   693 GIVLLQWYEPMQRFMLIKHFDFPVPSPLRVFEMLVVPEQEYPLVCVAVSQGSEPGQVVRFQTINL 757

Human   727 NSASSWFTEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIES 791
            ||.||||||:|:|..|:|:|||||||||||||||||.||||||||||||:|||||||||||.::|
Zfish   758 NSCSSWFTEVGSGGNQVDAIHVTQLERDTVLVCLDKNVKIVNLQGKLKSNKKLASELSFDFCVDS 822

Human   792 VVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYIL 856
            |||||||||||||||||||:|||:||||||||.:|||||||||||||||||||:||||:||||||
Zfish   823 VVCLQDSVLAFWKHGMQGKNFKSNEVTQEISDPSRVFRLLGSDRVVVLESRPTDNPTAYSNLYIL 887

Human   857 AGHENSY 863
            |||||||
Zfish   888 AGHENSY 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K5	XP_047286846.1	STKc_MAP4K5	10..277	CDD:270813	238/266 (89%)
		CNH	528..843	CDD:214481	271/314 (86%)
map4k5	XP_021336201.1	STKc_MAP4K5	10..277	CDD:270813	238/266 (89%)
		CNH	559..874	CDD:214481	271/314 (86%)