Protein Alignment MAP4K5 and sid1

DIOPT Version :10

• Sequence 1: XP_047286846.1
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 863
• Species: Homo sapiens
• Sequence 2: NP_593564.1
• Gene: sid1 / 2542746
• PomBaseID: SPAC9G1.09
• Length: 471
• Species: Schizosaccharomyces pombe
• Alignment Length: 572
• Identity: 173/572 - (30%)
• Similarity: 262/572 - (45%)
• Gaps: 137/572 - (23%)

Human    20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPG-DDFSLIQQEIFMVKECKHCNIVAYFGS 83
            |.|::::|||::|.|:|||...:|::.|:|.|.||.| ||.:.|:||:||:..|...|::.|:|.
pombe     9 YTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNSSNVIQYYGC 73

Human    84 YLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILL 148
            ::....|||.||:..|||:..:..: |.|:|..|:.:.||.|.||.|||.:.|:|||||.|||||
pombe    74 FVDGYTLWILMEHMDGGSVSGLLKM-GRLNEQVISIILREVLYGLNYLHGQNKIHRDIKAANILL 137

Human   149 TDH-GDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELG 212
            :.. |:||||||||||:::...::|.:|:|||:||||||.   :...|....|||::||||||:.
pombe   138 SSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVI---QQTSYGLAADIWSLGITAIEMA 199

Human   213 ELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
            ...||...:||||.:|.:.:|  :||||.|  .:|.||.:||...|..||..|.:|:.||.|.|:
pombe   200 NGIPPRATMHPMRVIFEIPQS--EPPKLDD--HFSPTFRDFVSCCLDLNPNMRWSAKELLQHPFI 260

Human   278 AQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINYQPF 342
            ...|..:.:...|:.|.|.        ..||.|   .:::..||.:|              .:||
pombe   261 KSAGTVKDIIPLLVQKENK--------LFDDSD---QSVLEETINNT--------------LKPF 300

Human   343 EMLSLYIPVIYFAVDKLQFEPPLRKETEARD---EMGLSSDPNFMLQWNPFVDGANTGKSTSKRA 404
            |                  ||......:..|   |....||...:         .||.
pombe   301 E------------------EPIAEGNADIEDWTFETVKKSDSTVL---------GNTS------- 331

Human   405 IPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGDGI 469
                :|....|||..::..|     |:||:...:      |:..|::|              ...
pombe   332 ----IPKNSIISSQNKEELP-----SSIKYLEKT------IMSDQATP--------------HPF 367

Human   470 SKLMSENTEGSAQAPQLPRKKDKRDFPKPAING------LPPTPKVLMGACFSKVFDGCPLKINC 528
            ||.:||  :||:....|......:.:.|..|..      |..|.:..:.:.::....   |..|.
pombe   368 SKSLSE--KGSSYHKSLTSDFAMKHYIKSTIRSMLLNDKLSATQRSSLESFYTSFIS---LDKNL 427

Human   529 ATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQ------LFPRKCTWL 574
            ::.:::..|.|                |.||....::      ||.|   ||
pombe   428 SSKFVNQITPD----------------NRLHHKKQKRSPISQLLFSR---WL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K5	XP_047286846.1	STKc_MAP4K5	10..277	CDD:270813	117/258 (45%)
		CNH	528..843	CDD:214481	10/53 (19%)
sid1	NP_593564.1	STKc_MST3_like	7..279	CDD:270786	121/277 (44%)