Protein Alignment MAP4K5 and gck-2

DIOPT Version :10

• Sequence 1: XP_047286846.1
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 863
• Species: Homo sapiens
• Sequence 2: NP_504721.1
• Gene: gck-2 / 179072
• WormBaseID: WBGene00022603
• Length: 829
• Species: Caenorhabditis elegans
• Alignment Length: 911
• Identity: 366/911 - (40%)
• Similarity: 519/911 - (56%)
• Gaps: 143/911 - (15%)

Human     8 AADILRR-NPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKE 71
            :||:::| ||..||||:|||||||||:|||||::.:..|||||::|||.||:|::|||||.:::|
 Worm     2 SADVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIMVIRE 66

Human    72 CKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGK 136
            |.|.||:||||||:.|::|||.||||||||||||||:||||||||||:||||||:||.|||..||
 Worm    67 CSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGK 131

Human   137 MHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDI 201
            :|||||||||||:..||||||||||||:|||||.|||||||||||||||||.|||.|||...||:
 Worm   132 IHRDIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMQCDV 196

Human   202 WAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRP 266
            ||.|||||||||.|||:||||||:.|:||:||.::||.||||.:|:..||:||:..|||||||||
 Worm   197 WATGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRP 261

Human   267 TAERLLT-HTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARA 330
            :.|:||| |.||. ..||..:..:||||||.         |..|.::                |.
 Worm   262 SPEKLLTSHPFVL-GSLSARMTRDLLDKVNG---------APTDVYD----------------RM 300

Human   331 ERTASEINYQPFEM---LSLYIPVIYFAVDKLQFEPPLR---------KETEARDEMGLSSDPNF 383
            .:|..::..:..:|   .||..|          ...|:|         ...:||....|||.|
 Worm   301 SKTVDDLTEEESDMDDAPSLLTP----------DAAPIRIGLPAHLNGLRLDARCLEQLSSSP-- 353

Human   384 MLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDN---------FPDEEKASTIKHC---- 435
                       ||...:.:|.  |...|:.....|..:.         .||......:.||
 Worm   354 -----------NTSSESDRRT--PTATPRSLNRGYHSERTLPAKEMPLLPDVVGGDALLHCGNGV 405

Human   436 ---PDSESRAPQILRRQSSPSCGPVAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPK 497
               .|...|||     ::.|.....|:.::.||        |:|...|......|.:.....|
 Worm   406 IHDDDETLRAP-----RAPPRTLRAAQKAAAGN--------SKNRFSSTSIASTPSEDGLTTF-- 455

Human   498 PAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEAT 562
               .|:|..|||.||||||||.|...||||||.||:||.|....::||||.|||:.:.|.:.:..
 Worm   456 ---FGMPLIPKVPMGACFSKVMDRTELKINCAASWVHPLTGAHLLLFGTEQGIYSFDTNCMPDGN 517

Human   563 MEQLFPRKCTWLYVINNTLMSLSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKF 627
            :.::..|:|:|::|..:.|.:: :|.|..:|.|:|:||.:  |...|......::.|::.:|::.
 Worm   518 LSKIHHRRCSWMFVYADRLTAI-QGNTPYVYRHDLVALTQ--KNLTLKMSKNLNKIPEKYVPKRL 579

Human   628 ALTTKIPDTKGCHKCCIVR--NPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPS--- 687
            |:|.::|:|:|..:|.:.|  .......:||.|::..:.|.|||.||.:|:|::  ..|:..
 Worm   580 AITVRMPETRGALQCTVKRGQGAQANSLFLCCAVRKTVHLFQWYNPMNQFVLVR--SEPIREDIR 642

Human   688 -PLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETIN-------------LNS-----ASSWF 733
             |:..|.::.....::|.:|:.:.:.:.||: .||..||             |||     |....
 Worm   643 FPIRPFALINSRTSDFPELCIGVGQMSGSNE-YQFNMINFCSSTNNSELSGDLNSSYGSLADDEM 706

Human   734 TEIGAGSQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDS 798
            .|:|       |:|  |::|||:.......|.:.:|||   ..:...|..:|:|.||.:..:..:
 Worm   707 LEVG-------SMH--QIDRDTLCFSFRNKVVLTDLQG---FERPKPSIFTFNFHIEYLHVVDGT 759

Human   799 VLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRP--TENPTAHSNLYILAGHEN 861
            :|||..:|:||:..||:..||::.|.:|::|::|.|||::|.|:|  ..|.....::.:|.||.:
 Worm   760 ILAFHANGVQGRDLKSNLNTQDLCDVSRLYRVIGDDRVIILRSQPMSPRNSGDTCDVSLLMGHTD 824

Human   862 S 862
            :
 Worm   825 T 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K5	XP_047286846.1	STKc_MAP4K5	10..277	CDD:270813	193/268 (72%)
		CNH	528..843	CDD:214481	100/338 (30%)
gck-2	NP_504721.1	STKc_MAP4K3_like	14..273	CDD:270788	189/258 (73%)
		CNH	483..804	CDD:214481	100/338 (30%)