Protein Alignment MAP4K5 and map4k5

DIOPT Version :9

• Sequence 1: NP_006566.2
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 846
• Species: Homo sapiens
• Sequence 2: NP_001135521.1
• Gene: map4k5 / 100216063
• XenbaseID: XB-GENE-6037447
• Length: 861
• Species: Xenopus tropicalis
• Alignment Length: 865
• Identity: 700/865 - (80%)
• Similarity: 765/865 - (88%)
• Gaps: 28/865 - (3%)

Human     3 APLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIF 67
            |.:||:|||||:|||.|:|||||||||||||||||||:.|||||||||||||.||||||||||||
 Frog     4 AAVRPSADILRKNPQHDFELVQRVGSGTYGDVYKARNLQTGELAAVKIIKLEQGDDFSLIQQEIF 68

Human    68 MVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLH 132
            |||||||.|||||||||||||||||||||||||||||||||||||:|.||||:||||||||.|||
 Frog    69 MVKECKHANIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLTECQIAYMCRETLQGLGYLH 133

Human   133 TKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQ 197
            ::||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
 Frog   134 SRGKMHRDIKGANILLTDNGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQ 198

Human   198 LCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNP 262
            ||||||||||||||.|||||||||||||||||||||||||||||:|.|||.:||||||::|.|||
 Frog   199 LCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKEKMKWSQSFHNFVKVSLIKNP 263

Human   263 KKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRN 327
            ||||.|||||||.||.||||||.:|.|||||.||||:|.||.|.||||.||.:::|||||||::.
 Frog   264 KKRPPAERLLTHQFVVQPGLSRIVAQELLDKFNNPDSHHHYGEPDDDDPEPLSMVRHTIRSTSKA 328

Human   328 ARAERTASEINFDKLQFEPPLRKETEARDEMGLSSDPNFMLQWNPFVDGANTGKSTSKRAIPPPL 392
            |||||||||:|||||||||||||||||.:.||.|.:.:|..||..|.:||| ..||.|:|:||||
 Frog   329 ARAERTASELNFDKLQFEPPLRKETEANEGMGCSRENDFGAQWISFANGAN-NDSTMKKAVPPPL 392

Human   393 PPKP-RISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAE------TSSI---- 446
            |||| |::|.|::|..|.|::|||||  ..|:||||..||||||.||....      ||||
 Frog   393 PPKPVRMNSCPDENMDDSERSSTIKH--QQENRAPQFHRRQSSPGCGHQGALSHNVLTSSISSPG 455

Human   447 ---------GNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVF 502
                     ||||  |.:.|...||.  .||||:||:|:|.||..||||||||||||||||||||
 Frog   456 LYSSRNCDMGNGD--SPVRSPIGEGG--KPQLPQKKEKKDIPKSVINGLPPTPKVLMGACFSKVF 516

Human   503 DGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSL 567
            ||||||||||||||||||||||||||:|||||||||||||||||||||||||||||::||.||||
 Frog   517 DGCPLKINCATSWIHPDTKDQYIIFGSEDGIYTLNLNELHEATMEQLFPRKCTWLYIMNNMLMSL 581

Human   568 SEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPY 632
            |||||.|||||||:.|||.|||||||||||||||||:||||||||:|||||||||||||:|||||
 Frog   582 SEGKTVQLYSHNLVGLFEQAKKPGLAAHIQTHRFPDKILPRKFALSTKIPDTKGCHKCCVVRNPY 646

Human   633 TGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTE 697
            ||||||||||:|.||||||||||||||||||||||||:||.|||||||||||||:||||:|||.|
 Frog   647 TGHKYLCGALESSIVLLQWYEPMQKFMLIKHFDFPLPNPLRVFEMLVIPEQEYPLVCVAVSKGVE 711

Human   698 SNQVVQFETINLNSASSWFTEIGAG-SQQLDSIHVTQLERDTVLVCLDKFVKIVNLQGKLKSSKK 761
            .||||:|||:||:|||||||::.:| .||||:|||||||:||||||||.:||||||||||||::|
 Frog   712 PNQVVRFETLNLSSASSWFTDLDSGICQQLDAIHVTQLEKDTVLVCLDHYVKIVNLQGKLKSNRK 776

Human   762 LASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQEISDETRVFRLLGSDRVVVLESRP 826
            |||||||:|||.||||||||||||||||||||:|||:|||||||||:||||||||||||||||||
 Frog   777 LASELSFEFRIGSVVCLQDSVLAFWKHGMQGKNFKSNEVTQEISDESRVFRLLGSDRVVVLESRP 841

Human   827 TENPTAHSNLYILAGHENSY 846
            |.||||||||||||||||||
 Frog   842 TMNPTAHSNLYILAGHENSY 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K5	NP_006566.2	STKc_MAP4K5	10..277	CDD:270813	242/266 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..485		97/181 (54%)
		CNH	511..826	CDD:214481	276/315 (88%)
map4k5	NP_001135521.1	STKc_MAP4K5	11..278	CDD:270813	242/266 (91%)
		S_TKc	21..278	CDD:214567	234/256 (91%)
		CNH	525..841	CDD:214481	276/315 (88%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	550	1.000	Domainoid score	I2968
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38199
Inparanoid	1	1.050	1379	1.000	Inparanoid score	I1706
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45812
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		oto151532
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080