DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC2A6 and CG6484

DIOPT Version :9

Sequence 1:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens
Sequence 2:	NP_611234.1	Gene:	CG6484 / 36994	FlyBaseID:	FBgn0034247	Length:	465	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	136/467 - (29%)
Similarity:	241/467 - (51%)	Gaps:	24/467 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    39 FLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILN 103
            ::|..:|..|....|.::.::|||...:..:.:....::.||..|..|:.||||....:......
  Fly    10 YIAGLSASFGALCMGASIGWSSPVENMITVNTEYGFPISSSQFGWVSSLLTLGATVICIPIGFAI 74

Human   104 DLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGA 168
            |.:||:.:::....|...|:.||..|..:.||..||.:.|..||......|:|.:||....:||.
  Fly    75 DWIGRRPTMLALIPPYMVGWVLMLFAKNVTMLYFGRFILGMCGGAFCVTAPMYCTEITATALRGT 139

Human   169 LGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEALRA 233
            :|:..||:.|.|.|..|.:|..||...:.:......:|..::..|||.||.:|..:||:::|.:|
  Fly   140 IGSFFQLLIVSGVLYGYLVGAFLPLLTINILCAILPVIFAIIHFFMPESPVYLAMKGRNDDAAKA 204

Human   234 LAWLRGTDVDVHWEFEQIQDNVRRQSSRVS---WAEARAPHVCRPITVALLMRLLQQLTGITPIL 295
            |.||||.|.|:..|.::|.:..::|.....   .:..|.|.|.:.:.:|:|:::.||.|||..:|
  Fly   205 LQWLRGKDADIDDELKEILEESQKQIDMPQVNILSSLRRPIVLKGLGIAVLLQVFQQWTGINAVL 269

Human   296 VYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYI 360
            .|..|||:.|...:...|...|:|..::.|.|:|...:|.|||::||.:|..:|..:...:|:|.
  Fly   270 FYSASIFEDTGSDISGSDATLIIGVTQVTSTLVAVAIIDKAGRRILLLISGVLMAVSTALMGVYF 334

Human   361 HFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVL 425
            .     |..|..|.:::..|                :|:.:..:||:.:::|:||:.||:|:|:.
  Fly   335 Q-----LKENDPASMDNFGW----------------LPISSICIFIIFFSIGFGPVPWLVMAELF 378

Human   426 PLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRS 490
            ....:.||..:...::||:|||:|..|..:.|:.|....|:.|.||.:::..::...||||||::
  Fly   379 SEDVKSVAGSIAGTSNWLSAFVVTLLFPILKSSIGPGPTFWIFTAIAVIAFFYSLFFVPETKGKT 443

Human   491 LEQIESFFRTGR 502
            :.:|:.....|:
  Fly   444 IIEIQDLLSGGK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	134/456 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		4/5 (80%)
CG6484	NP_611234.1	Sugar_tr	14..451	CDD:278511	134/457 (29%)
CG6484	NP_611234.1	MFS	14..436	CDD:119392	127/442 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850