Protein Alignment SLC2A6 and CG42826

DIOPT Version :10

• Sequence 1: NP_060055.2
• Gene: SLC2A6 / 11182
• HGNCID: 11011
• Length: 507
• Species: Homo sapiens
• Sequence 2: NP_001189079.1
• Gene: CG42826 / 10178905
• FlyBaseID: FBgn0262008
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 544
• Identity: 123/544 - (22%)
• Similarity: 193/544 - (35%)
• Gaps: 143/544 - (26%)

Human    17 PEKPPPSPGDRARVGTLQNKRVFL---------------ATFAAVLGNFSFGYALVYTSPVIPAL 66
            |:|..|.|.|  .:.|.: |..||               |:|..:.|..|..:...:   .:.:.
  Fly     3 PKKCEPPPED--SLATTE-KATFLRLGHKNHSQWTALGSASFILISGGMSLAWGAGF---AVHSA 61

Human    67 ERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHG 131
            .|  |..|.....|.:|:.:. .|||..|   |...:.|..:.:.|..|.:..|:|...:|....
  Fly    62 HR--DQLLRTVHMQIAWYATA-VLGALFG---AFYTHRLPQQPIYIFSSILVIASGILFLAWPEC 120

Human   132 LWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLL----- 191
            ...::..|.|.|.|.||........|.||:...:||.|.:|.:.::       :..|:||
  Fly   121 PGAIIAARYLDGLANGLVFVPALSTVGEISVNEIRGLLASTVEQLS-------FNTGILLQLIYT 178

Human   192 -----PWRWLAVAGEA--------PVLIMILLLSFMPNSPRFLLSRGRDEEALRALAWLRG---- 239
                 .|....||.:.        .|:.:.|.|:....||..||.|..::.||.||..|:.
  Fly   179 AVWQVDWNVAIVADQVHGVLSIVYGVIALALALTLCVESPVHLLMRSSEQRALVALRHLQRPYMV 243

Human   240 -----TDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQ 299
                 ..:|.|.::  :.||  |:....|..:...|.|.:    .|.:|||..|:        |.
  Fly   244 TSEMLLRLDEHKQY--VADN--REMCLGSSLQKGYPSVLK----LLALRLLGVLS--------LN 292

Human   300 SIFDS----------TAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRK----VLLFVSAAIMF 350
            ||..|          :.:...|   ..:.|.:|......|.|.||..|||    ..:|.:.|...
  Fly   293 SIICSALYETGNQLVSCLYAWP---FVVFGLLRWGGCFFAVLLMDTTGRKKPTLFGIFSTGAFAI 354

Human   351 A-ANLTLGLYIHFGPRPLSPNSTAGLES----ESWGDLAQPLAAPAGY-LTLVPLLATMLFIMGY 409
            | |||       ||..|....:...|.|    |..|..|..:....|: |.:.|.:..:::||..
  Fly   355 AYANL-------FGRTPHMITALVMLFSLQFFEGLGQCASAVYLTEGFPLLMKPHMVAVVYIMEQ 412

Human   410 AVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLV 474
            |                                  |.:|..||||.::.  :...|....|:.:|
  Fly   413 A----------------------------------ARLLLCSFLPSIAE--ITAYFHSMGALSMV 441

Human   475 SLVFTGCCVPETKGRSLEQIESFF 498
            ..:....|:|||:..:|.:.:..|
  Fly   442 CFLLGIFCLPETRLVTLAEAQLKF 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		5/10 (50%)
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	115/515 (22%)
CG42826	NP_001189079.1	MFS	35..460	CDD:475125	113/502 (23%)