Protein Alignment TREH and Treh

DIOPT Version :10

• Sequence 1: NP_009111.2
• Gene: TREH / 11181
• HGNCID: 12266
• Length: 583
• Species: Homo sapiens
• Sequence 2: NP_726025.1
• Gene: Treh / 45368
• FlyBaseID: FBgn0003748
• Length: 596
• Species: Drosophila melanogaster
• Alignment Length: 557
• Identity: 242/557 - (43%)
• Similarity: 349/557 - (62%)
• Gaps: 17/557 - (3%)

Human    21 QEALPPPCESEIYCHGELLNQVQMA--KLYQDDKQFVDMPLSIAPEQVLQTFTELSRDHNHSIPR 83
            :||..|....:|||.|.||:.:|.|  ||:.|.|.||||.|:.:|::.|:.|..:....|.:...
  Fly    44 EEAQDPFASCKIYCEGNLLHTIQTAVPKLFADSKTFVDMKLNNSPDKTLEDFNAMMEAKNQTPSS 108

Human    84 EQLQAFVHEHFQAKGQELQPWTPADWKDSPQFLQKISDAKLRAWAGQLHQLWKKLGKKMKPEVLS 148
            |.|:.||.::|.|.|.||:.|||.|||::|.||..|||..|:.|..:|:.:||.||:|||.||..
  Fly   109 EDLKQFVDKYFSAPGTELEKWTPTDWKENPSFLDLISDPDLKQWGVELNSIWKDLGRKMKDEVSK 173

Human   149 HPERFSLIYSEHPFIVPGGRFVEFYYWDSYWVMEGLLLSEMAETVKGMLQNFLDLVKTYGHVPNG 213
            :||.:|:|...:|.|||||||:|||||||||::.|||.|:|.:|.:||::||..:|..:|.:|||
  Fly   174 NPEYYSIIPVPNPVIVPGGRFIEFYYWDSYWIIRGLLYSQMFDTARGMIENFFSIVNRFGFIPNG 238

Human   214 GRVYYLQRSQPPLLTLMMDCYLTHTNDTAFLQENIETLALELDFWTKNRTVSVSLEGKNYLLNRY 278
            |||||..||||||||.|:..|:..|||..|..:.::||..|.:|:..|..|:|    ||:.|..|
  Fly   239 GRVYYHGRSQPPLLTGMVKSYVDFTNDDKFAIDALDTLEHEFEFFVNNHNVTV----KNHSLCVY 299

Human   279 YVPYGGPRPESYSKDVELADTLPEGD-REALWAELKAGAESGWDFSSRWLIG--GPNPNSLSGIR 340
            .....|||||||.:|||..:..|..: :|..::|||||||||.||||||.|.  |.|..:.|.:.
  Fly   300 RDSSSGPRPESYREDVETGEEFPTDEAKELHYSELKAGAESGMDFSSRWFISPTGTNDGNRSALS 364

Human   341 TSKLVPVDLNAFLCQAEELMSNFYSRLGNDSQATKYRILRSQRLAALNTVLWDEQTGAWFDYDLE 405
            |:.:|||||||:|....:|::.|:|:.||..:.|:|.....:.|..:..|||:|:.|.|.|||:.
  Fly   365 TTSIVPVDLNAYLYWNAKLIAEFHSKAGNTKKVTEYETKAEKLLLGIQEVLWNEEAGVWLDYDMI 429

Human   406 KKKKNREFYPSNLTPLWAGCFS---DPGVADKALKYLEDNRILTYQYGIPTSLQKTGQQWDFPNA 467
            .:|....:.|:||:|||...|:   ...::...:.|:|.|::.::..|:|.:|..||:|||.||.
  Fly   430 NQKPRDYYTPTNLSPLWVKAFNISESEKISASVMAYIERNKLDSFPGGVPNTLSYTGEQWDAPNV 494

Human   468 WAPLQDLVIRGLAKAPLRRAQEVAFQLAQNWIRTNFDVYSQKSAMYEKYDVSNGGQPGGGGEYEV 532
            |||:|.:::.||.......|:.::.:.|..|::|||..:|:...|||||:....|..||||||||
  Fly   495 WAPMQYILVEGLNNLNTPEAKNMSLKWATRWVKTNFAAFSKDRHMYEKYNADEFGVGGGGGEYEV 559

Human   533 QEGFGWTNGVVLMLLDRYGDRLTSGAKLAFLEPHCLA 569
            |.||||:|||::..|.::|..::.|:...     |||
  Fly   560 QTGFGWSNGVIIEWLSKHGRDISIGSGCG-----CLA 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TREH	NP_009111.2	Trehalase	46..551	CDD:395961	226/510 (44%)
Treh	NP_726025.1	Trehalase	71..578	CDD:395961	226/510 (44%)