DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF277 and znf277

DIOPT Version :9

Sequence 1:	NP_068834.2	Gene:	ZNF277 / 11179	HGNCID:	13070	Length:	450	Species:	Homo sapiens
Sequence 2:	NP_956724.1	Gene:	znf277 / 393402	ZFINID:	ZDB-GENE-040426-1633	Length:	440	Species:	Danio rerio

Alignment Length:	420	Identity:	271/420 - (64%)
Similarity:	336/420 - (80%)	Gaps:	3/420 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    33 KDCILEPLSLPES-PGGTTTLEGSPSVP--CIFCEEHFPVAEQDKLLKHMIIEHKIVIADVKLVA 94
            :|||||||..||: ..|......|...|  |..|.:.||.:|:|:|||||::|||:|||||||:|
Zfish    14 QDCILEPLCFPENFSDGVCLASSSDGCPMTCALCPDLFPASEKDQLLKHMVLEHKLVIADVKLIA 78

Human    95 DFQRYILYWRKRFTEQPITDFCSVIRINSTAPFEEQENYFLLCDVLPEDRILREELQKQRLREIL 159
            ||.:|:|||:||||||||||:||||:.||..|.::||:||||||.|||||||||:||::||.|:|
Zfish    79 DFSQYMLYWKKRFTEQPITDYCSVIKTNSEGPVDQQEHYFLLCDALPEDRILREQLQQRRLEEVL 143

Human   160 EQQQQERNDTNFHGVCMFCNEEFLGNRSVILNHMAREHAFNIGLPDNIVNCNEFLCTLQKKLDNL 224
            ||||:||:|..||.:||||:|||.||||.:|||||:||:|:||||||||.|:|||.||:.||||:
Zfish   144 EQQQKERDDETFHRICMFCSEEFTGNRSSLLNHMAKEHSFSIGLPDNIVYCDEFLNTLESKLDNM 208

Human   225 QCLYCEKTFRDKNTLKDHMRKKQHRKINPKNREYDRFYVINYLELGKSWEEVQLEDDRELLDHQE 289
            ||||||||||||.||||||||||||:||.:|..||||||||||||||:|||||.|||||:|:.::
Zfish   209 QCLYCEKTFRDKTTLKDHMRKKQHRRINARNHGYDRFYVINYLELGKTWEEVQSEDDREMLEDED 273

Human   290 DDWSDWEEHPASAVCLFCEKQAETIEKLYVHMEDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQV 354
            ||||||:.||..||||||::||||::|:|.||::.|||||.|:|.:|.|.|||||||||:|||::
Zfish   274 DDWSDWQAHPVCAVCLFCDQQAETMDKIYTHMQETHEFDLHKLKMDLSLKFYQQVKLVNYIRREL 338

Human   355 HQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRKTWDQLEYYFPTYENDTLLCTLSDSESDLTA 419
            ||||||.|..||:||.:|..|:....|...|||...|||.:|||||||||.||..|||.||:...
Zfish   339 HQCRCYCCQEKFESKEELVQHLVTAGHVMQLPDVSHWDQPQYYFPTYENDALLTALSDGESESEG 403

Human   420 QEQNENVPIISEDTSKLYALKQSSILNQLL 449
            ...:..||:|:||.|.|..|:|:|:||:||
Zfish   404 TNHSSEVPVIAEDISNLKVLRQTSVLNKLL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF277	NP_068834.2	zf-C2H2_2	175..262	CDD:289522	67/86 (78%)
		C2H2 Zn finger	226..248	CDD:275371	20/21 (95%)
		zf-C2H2_2	304..402	CDD:289522	58/97 (60%)
znf277	NP_956724.1	zf-C2H2_2	159..246	CDD:289522	67/86 (78%)
		C2H2 Zn finger	210..232	CDD:275371	20/21 (95%)
		zf-C2H2_2	288..386	CDD:289522	58/97 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338075
Domainoid	1	1.000	167	1.000	Domainoid score	I15810
eggNOG	1	0.900	-	-		E1_KOG2482
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11087
Inparanoid	1	1.050	597	1.000	Inparanoid score	I5302
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54460
OrthoDB	1	1.010	-	-		D1498904at2759
OrthoFinder	1	1.000	-	-		FOG0005654
OrthoInspector	1	1.000	-	-		oto43198
orthoMCL	1	0.900	-	-		OOG6_104708
Panther	1	1.100	-	-	LDO	PTHR13267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.310