DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF277 and ztf-7

DIOPT Version :9

Sequence 1:	NP_068834.2	Gene:	ZNF277 / 11179	HGNCID:	13070	Length:	450	Species:	Homo sapiens
Sequence 2:	NP_505526.1	Gene:	ztf-7 / 179375	WormBaseID:	WBGene00009772	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	176/468 - (37%)
Similarity:	258/468 - (55%)	Gaps:	52/468 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    31 DSKDCILEPLSLPESPGGTTTLEGSPSVP-------------CIFCEEHFPVAEQ-DKLLKHMII 81
            ||:....|.:||..:.|...||.|  :||             |:.|.|.|.:.|| .....|::.
Worm   150 DSRPKKPEKMSLTVARGRIRTLSG--TVPVVGYSPRWGGPTMCVSCLEFFDLPEQISGFADHLLK 212

Human    82 EHKIVIADVKLVADFQRYILYWRKRFTEQPITD-FCSVIRINSTAPFEEQENYFLLCDVLPEDRI 145
            |||||::::.|:.|.:|||.:||:||.::.|.. |..:......:.|.|.:.|:|:.:.:.|||.
Worm   213 EHKIVVSEMNLIVDPKRYIEHWRQRFAKESIDKIFPRIEPSEGDSYFGETDYYYLMSENVAEDRS 277

Human   146 LREELQKQRLREILEQQQQERNDTNFHGVCMFCNEEFLGNRSVILNHMAREHAFNIGLPDNIVNC 210
            ||:.|..:||.|.|:.||:||.||:|...|:||.....||||.|::|:...|..|:|.|||:|..
Worm   278 LRQRLAMRRLEEALQCQQREREDTSFQLQCIFCRYNARGNRSKIIHHLYMIHHLNLGSPDNLVFV 342

Human   211 NEFLCTLQKKLDNLQCLYCEKTFRDKNTLKDHMRKKQHRKINPKNREYDRFYVINYLELGKSWEE 275
            .|::..|::||...:|:||||.|.|:|||.|||||:.||::||||..||:||:||||||||.|.:
Worm   343 TEYIEHLKEKLHRNECIYCEKIFPDRNTLMDHMRKRNHREVNPKNHYYDKFYIINYLELGKRWLD 407

Human   276 VQLEDDRELL------DHQEDD--WSDWEEHPASA-----VCLFCEKQAETIEKLYVHMEDAHEF 327
            |..||..:.:      |.:|:|  |.:|:|....|     |||.|:...:..:.|..||:..|||
Worm   408 VLAEDFEDTMPTFQDSDEEEEDNEWCEWQEDNLDADETRVVCLLCDASEDNAQSLLEHMKTTHEF 472

Human   328 DLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCH-VKFKSKADLRTHMEETKHTSLLPDRKTW 391
            ||||..|:..||.||:::|:|:||:|.:...|:.|. .:|::...|:.|:.|.|..|.|||...|
Worm   473 DLLKNVSDDKLNSYQRLRLINYIRKQNYHADCWVCQKTEFENPLALQKHILEHKPLSHLPDASIW 537

Human   392 DQLEYYFPTYENDTLLCTL------------SDSE-------SDLTAQEQNENVP-IISEDTSKL 436
            |..|...|.:.||..|..|            ||.|       |.|..:.::..|. :|:||..:|
Worm   538 DTEENLVPIFGNDHFLWMLESILEENEITCSSDDEGESEERFSKLVLESKSNTVEGVIAEDLPEL 602

Human   437 YALKQSSILNQLL 449
            ..|.:.. ||.|:
Worm   603 SELNEDD-LNALM 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF277	NP_068834.2	zf-C2H2_2	175..262	CDD:289522	43/86 (50%)
		C2H2 Zn finger	226..248	CDD:275371	15/21 (71%)
		zf-C2H2_2	304..402	CDD:289522	38/98 (39%)
ztf-7	NP_505526.1	PTZ00108	<1..152	CDD:240271	1/1 (100%)
		zf-C2H2_2	307..394	CDD:372293	43/86 (50%)
		C2H2 Zn finger	358..380	CDD:275371	15/21 (71%)
		zf-C2H2_2	449..>521	CDD:372293	27/71 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161465337
Domainoid	1	1.000	114	1.000	Domainoid score	I4189
eggNOG	1	0.900	-	-		E1_KOG2482
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11087
Inparanoid	1	1.050	296	1.000	Inparanoid score	I1892
Isobase	1	0.950	-	0	Normalized mean entropy	S6300
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1498904at2759
OrthoFinder	1	1.000	-	-		FOG0005654
OrthoInspector	1	1.000	-	-		oto23004
orthoMCL	1	0.900	-	-		OOG6_104708
Panther	1	1.100	-	-	LDO	PTHR13267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1950
SonicParanoid	1	1.000	-	-		X4057
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.780