DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BAZ1A and Baz1a

DIOPT Version :9

Sequence 1:	NP_038476.2	Gene:	BAZ1A / 11177	HGNCID:	960	Length:	1556	Species:	Homo sapiens
Sequence 2:	NP_038843.2	Gene:	Baz1a / 217578	MGIID:	1309478	Length:	1552	Species:	Mus musculus

Alignment Length:	1557	Identity:	1358/1557 - (87%)
Similarity:	1449/1557 - (93%)	Gaps:	6/1557 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQ 65
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MPLLHRKPFVRQKPPGDLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQ 65

Human    66 EALESEKKARQNLQSFPEPLIIPVLYLTSLTHRSRLHEICDDIFAYVKDRYFVEETVEVIRNNGA 130
            ||||||:|||||||||||||||||||||:||.||||||||||||||||||||||||||||||||.
Mouse    66 EALESERKARQNLQSFPEPLIIPVLYLTNLTRRSRLHEICDDIFAYVKDRYFVEETVEVIRNNGT 130

Human   131 RLQCRILEVLPPSHQNGFANGHVNSVDGETIIISDSDDSETQSCSFQNGKKKDAIDPLLFKYKVQ 195
            ||||||||||||.|||||||||::|.|||||:|||||||||||.||.:||||||||||||:|:||
Mouse   131 RLQCRILEVLPPLHQNGFANGHLSSADGETIVISDSDDSETQSSSFHHGKKKDAIDPLLFRYRVQ 195

Human   196 PTKKELHESAIVKATQISRRKHLFSRDKLKLFLKQHCEPQDGVIKIKASSLSTYKIAEQDFSYFF 260
            |||||::|||:|||||||||||||||||||||||||||.|||||||||||.|.|.||||||||||
Mouse   196 PTKKEMYESAVVKATQISRRKHLFSRDKLKLFLKQHCEAQDGVIKIKASSFSAYNIAEQDFSYFF 260

Human   261 PDDPPTFIFSPANRRRGRPPKRIHISQEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFEKA 325
            |||||||||||||||||||||||...|||::|:|||.|.||:||.||||||||||||::||||||
Mouse   261 PDDPPTFIFSPANRRRGRPPKRISFGQEDSIASKQTAARYRNKAIKERDKLLKQEEMRALAFEKA 325

Human   326 KLKREKADALEAKKKEKEDKEKKREELKKIVEEERLKKKEEKERLKVEREKEREKLREEKRKYVE 390
            |||||:||||||:|:||||||||||||||:||||||||||||||||:||||||||||||||||:|
Mouse   326 KLKRERADALEARKREKEDKEKKREELKKMVEEERLKKKEEKERLKIEREKEREKLREEKRKYME 390

Human   391 YLKQWSKPREDMECDDLKELPEPTPVKTRLPPEIFGDALMVLEFLNAFGELFDLQDEFPDGVTLE 455
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||:|||||
Mouse   391 YLKQWSKPREDMECDDLKELPEPTPVKTRLPPEVFGDALMVLEFLNAFGELFDLQDEFPEGVTLE 455

Human   456 VLEEALVGNDSEGPLCELLFFFLTAIFQAIAEEEEEVAKEQLTDADTKDLTEALDEDADPTKSAL 520
            |||||||||||||||||||||||||||||:|||||||||||:|||||||||||||||||||||||
Mouse   456 VLEEALVGNDSEGPLCELLFFFLTAIFQAMAEEEEEVAKEQITDADTKDLTEALDEDADPTKSAL 520

Human   521 SAVASLAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDA 585
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 SAVAALAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDA 585

Human   586 CMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDILRQAKQEFRE 650
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Mouse   586 CMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDVLRQAKQEFRE 650

Human   651 LKAEQHRKEREEAAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNSTADISIGEEEREDFDTSI 715
            |||||||||||..|||||:||||||||||||||||||||||||||||.|  ..|||||||||||.
Mouse   651 LKAEQHRKEREATAARIRRRKEEKLKEQEQKMKEKQEKLKEDEQRNSAA--VPGEEEREDFDTST 713

Human   716 ESKDTEQKELDQDMVTEDEDDPGSHKRGRRGKRGQNGFKEFTRQEQIN-CVTREPLTADEEEALK 779
            |:|:.|||:||.|:|||||||||||||.||||.||...|:..:||::| |:.:|||:||.||||:
Mouse   714 ENKNIEQKDLDPDVVTEDEDDPGSHKRSRRGKVGQTAVKQCIKQEEMNYCIKQEPLSADAEEALR 778

Human   780 QEHQRKEKELLEKIQSAIACTNIFPLGRDRMYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSF 844
            ||.|:||||||:||||||||||||||||||:||||||||||||||||||||||||||||||||||
Mouse   779 QEQQQKEKELLDKIQSAIACTNIFPLGRDRLYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSF 843

Human   845 QNNVQSQDPQVSTKTGEPLMSESTSNIDQGPRDHSVQLPKPVHKPNRWCFYSSCEQLDQLIEALN 909
            .||.|.:|||||.||.|..:|||||::||||.|.||.|||||||||||||||||.||||||:|||
Mouse   844 HNNAQPRDPQVSIKTEESFLSESTSSLDQGPFDDSVLLPKPVHKPNRWCFYSSCAQLDQLIDALN 908

Human   910 SRGHRESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPSQMCAEKQ 974
            |||||||||||||||||||||||||.|||||||||||||.||||..||||||.|.|.|||.||:|
Mouse   909 SRGHRESALKETLLQEKSRICAQLAHFSEEKFHFSDKPQADSKPVSSRGRSSGACDISQMSAERQ 973

Human   975 LELRLRDFLLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGIIKTVNEDVEEME 1039
            |||||||||||||||||||||||||||||.:||||||:|||||||||:||||:||||||||||||
Mouse   974 LELRLRDFLLDIEDRIYQGTLGAIKVTDRQVWRSALENGRYELLSEESKENGVIKTVNEDVEEME 1038

Human  1040 IDEQTKVIVKDRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQIEQGIERRFLKAPLDASD 1104
            : ||.:|||:|||||||||||||:||:||||||||:||||||:|||||||||||||||||||.:|
Mouse  1039 M-EQARVIVRDRLLGIKTETPSTISTSASTPQSVSNVVHYLALALFQIEQGIERRFLKAPLDGND 1102

Human  1105 SGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDAENMVLCDGC 1169
            ||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||
Mouse  1103 SGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVMWSKSILNARCKICRKKGDAENMVLCDGC 1167

Human  1170 DRGHHTYCVRPKLKTVPEGDWFCPECRPKQRSRRLSSRQRPSLESDEDVEDSMGGEDDEVDGDEE 1234
            ||||||||||||||.||:|||||||||||||||||||||||||||||::|:.|..:|||||.|:|
Mouse  1168 DRGHHTYCVRPKLKAVPDGDWFCPECRPKQRSRRLSSRQRPSLESDEEMEEGMEDDDDEVDDDDE 1232

Human  1235 EGQSEEEEYEVEQDEDDSQEEEEVSLPKRGRPQVRLPVKTRGKLSSSFSSRGQQQEPGRYPSRSQ 1299
            |||||||||||||||:||.::|.:|.|||||||||||:||:|:...||.||.|:|:|||||||||
Mouse  1233 EGQSEEEEYEVEQDEEDSDDDEALSPPKRGRPQVRLPIKTKGRFGPSFPSRSQRQDPGRYPSRSQ 1297

Human  1300 QSTPKTTVSSKTGRSLRKINSAPPTETKSLRIASRSTRHSHGPLQADVFVELLSPRRKRRGRKSA 1364
            |||||.|..| ..::|||..|||||||:|||:.|||||||...|| |||||||||..||||||.|
Mouse  1298 QSTPKNTAKS-ASKNLRKTRSAPPTETRSLRVGSRSTRHSPSALQ-DVFVELLSPHSKRRGRKGA 1360

Human  1365 NNTPENSPNFPNFRVIATKSSEQSRSVNIASKLSLQESESKRRCRKRQSPEPSPVTLGRRSSGRQ 1429
            ::|||:||:|.||||..::||.|...:|.|..||||.||||||.|||||.|.|||.|.|||||||
Mouse  1361 DHTPEHSPSFTNFRVSTSRSSRQLIPLNTAESLSLQHSESKRRGRKRQSTESSPVPLNRRSSGRQ 1425

Human  1430 GGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEF 1494
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1426 GGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEF 1490

Human  1495 IDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVTPSNVDQVSTPPAAKKSRI 1556
            |||||||||||||||||||||||||||||||||||||||||||:||.|||||||.|||||||
Mouse  1491 IDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVSPSTVDQVSTPLAAKKSRI 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BAZ1A	NP_038476.2	Required for interaction with NCOR1. /evidence=ECO:0000269\|PubMed:17519354	1..133		126/131 (96%)
		Required for association with the CHRAC1/POLE3 complex	1..128		122/126 (97%)
		WAC_Acf1_DNA_bd	23..122	CDD:313708	95/98 (97%)
		DDT	422..485	CDD:214726	60/62 (97%)
		WHIM1	590..635	CDD:317926	44/44 (100%)
		Neuromodulin_N	<645..788	CDD:331332	108/143 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..754		72/91 (79%)
		Interaction with SMARCA5	667..933		215/266 (81%)
		WSD	800..926	CDD:317927	108/125 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	841..877		24/35 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..966		19/24 (79%)
		PHD_BAZ1A	1150..1195	CDD:277097	42/44 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1376		123/173 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1399..1431		25/31 (81%)
		Bromo_Acf1_like	1423..1535	CDD:99936	111/111 (100%)
Baz1a	NP_038843.2	Required for interaction with NCOR1. /evidence=ECO:0000250	1..133		126/131 (96%)
		Required for association with the CHRAC1/POLE3 complex. /evidence=ECO:0000250	1..128		122/126 (97%)
		WAC_Acf1_DNA_bd	23..122	CDD:371121	95/98 (97%)
		DDT	423..483	CDD:367184	57/59 (97%)
		WHIM1	591..635	CDD:373966	43/43 (100%)
		PTZ00121	<643..>795	CDD:173412	117/153 (76%)
		WSD	799..925	CDD:373967	108/125 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..871		20/30 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..966		19/24 (79%)
		PHD_BAZ1A	1148..1193	CDD:277097	42/44 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1200..1426		158/227 (70%)
		APC_basic	1255..>1437	CDD:368684	127/183 (69%)
		Bromo_Acf1_like	1418..1531	CDD:99936	111/112 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965657
Domainoid	1	1.000	544	1.000	Domainoid score	I6352
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45654
Inparanoid	1	1.050	2703	1.000	Inparanoid score	I774
Isobase	1	0.950	-	0	Normalized mean entropy	S5503
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45550
OrthoDB	1	1.010	-	-		D858930at2759
OrthoFinder	1	1.000	-	-		FOG0005585
OrthoInspector	1	1.000	-	-		oto121024
orthoMCL	1	0.900	-	-		OOG6_107600
Panther	1	1.100	-	-	LDO	PTHR46510
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4315
SonicParanoid	1	1.000	-	-		X4556
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	18	18.390