DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADAMTS7 and nolo

DIOPT Version :9

Sequence 1:	XP_005254194.1	Gene:	ADAMTS7 / 11173	HGNCID:	223	Length:	1689	Species:	Homo sapiens
Sequence 2:	NP_001036374.1	Gene:	nolo / 35424	FlyBaseID:	FBgn0051619	Length:	1394	Species:	Drosophila melanogaster

Alignment Length:	1499	Identity:	329/1499 - (21%)
Similarity:	459/1499 - (30%)	Gaps:	590/1499 - (39%)

- Green bases have known domain annotations that are detailed below.

Human   539 GGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQ 603
            |.||.||.||.|||:|..|:....|:|..|..      |.||..|:|:||:|.||. :..||..|
  Fly    76 GQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGS------CRGESTRYRICNMQPCPE-QQDFRSSQ 133

Human   604 CSHFDAMLYKGQLHTWVPVVNDVNPCELHCR--PAN-----------------EYFAE-----KL 644
            ||.::.:.|.|.|:.|.|..:.|.||.|.||  ||:                 |::.|     :|
  Fly   134 CSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQL 198

Human   645 RDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEG 709
            ...|.|||.|..  .|.|:||.|.|:.||||.:|.|....|.||||.|:|::|
  Fly   199 SARVQDGTRCRS--GSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSC------------ 249

Human   710 LGYVDVGLIPAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRG 774

  Fly   250 ----------------------------------------------------------------- 249

Human   775 NWENLTSPGPTKEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGR 839
                                                        ..|:|:|...|.::|:||||.
  Fly   250 --------------------------------------------SQPLFNWEMAPMSQCSVTCGS 270

Human   840 GVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRR 903
            |.:.....|..|.. ..||:..|....||:....:|:...||.||.|.:|..||..||.|...|.
  Fly   271 GYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERM 335

Human   904 AVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVL 968
            .|....|.|:  ::.:....| ..|:|||:..|... .|| .|.|.:|:.|||:||:|.|.|.|.
  Fly   336 VVCAEESNGI--KTRVADIMC-RTPKPPTQETCIIE-ECP-HWEVEDWTGCSVSCGQGIQMRGVE 395

Human   969 CTNDTG---VPCDEAQQPASEVTCSLPL-CRWPLGTLG--------------------------- 1002
            |.:..|   ..||...:|.|...||..: |...|..:|
  Fly   396 CKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADED 460

Human  1003 -----PEG-------SGSGSSSHELFNEAD---FIPHHLAPRPSPASSPKPGTM----GNA---- 1044
                 .||       ||..:...|..:.||   ...|....|.:..:..:|.||    ||:
  Fly   461 NEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNF 525

Human  1045 ----IEEEAPELDLPGPVFVDDFYYD--------------YN---FINF-------HEDLSYGPS 1081
                .|.|.|.||   |.::.|..:.              ||   |:.:       ::.|..|..
  Fly   526 NRGEDESEGPSLD---PTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKK 587

Human  1082 EEPDLDLAGTGDRTPPPHS-HPAAPSTGSPVPATEPPAA---KEEG------------------- 1123
            ...:::.........|.|. ....|.....|..:||...   :|:|
  Fly   588 PHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINC 652

Human  1124 -------VLGPW--SPSPWPSQAGRS----PPPP----SEQTPGNPLINFLPEEDTPIGAPDLGL 1171
                   |:.|:  ||...|....|:    |.||    |:.||.:        :...||.....:
  Fly   653 VREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCS--------KSCGIGIKTREV 709

Human  1172 PSLSWPRVSTDGLQTPATPESQNDFPVGKDSQ--SQLPPPWRDRTNE----------VFKDD--E 1222
            ..:.  .|:..|..|...|.|....|...|.|  :.|..|.|....|          .|||.  |
  Fly   710 QCIH--EVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVE 772

Human  1223 EPKGRGAPHLPPRPSSTLPPLSPV----------------------GSTHSSPSPDVAE--LWTG 1263
            ..:.....|...||.|..|...|.                      .|||....|...:  |..|
  Fly   773 CKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVG 837

Human  1264 GT----------------------VAW-------------EPALEGGLGPVDSELWPTVGVAS-- 1291
            |.                      :.|             :.:.:|.|..:|. .:...||.|
  Fly   838 GAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDI-TFRDAGVYSCH 901

Human  1292 -----------LLPPPIAPLPEMK-------VRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLP 1338
                       :...|...:.|::       ||:.|   ||.:..:....|.|       ||...
  Fly   902 AGLSSAEISIEVKAKPGQQIEELEQQETERLVREKS---GTEALTSADMKSAD-------GTGTS 956

Human  1339 TTLTGLGHMPEPALNPG--------------------PKG------------------------- 1358
            |.:....|:...|...|                    ||.
  Fly   957 TAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDLSQLVQSEDRI 1021

Human  1359 -QPESLSPEVPLSSRLLSTP-----------AW------DSPA---------------------- 1383
             ||.|.|.....:..||:.|           .|      ||..
  Fly  1022 PQPASASSGGSRTRTLLAMPYFQALLSNLQLLWPLQRFKDSRGQHLLQGEALKFGIDLSGKDFDQ 1086

Human  1384 -NSHRVPETQPLAPSL------------AEAGPPAD----PLVVRNAGWQAGNWSECSTTC---- 1427
             .|.|||..| |.|.:            :::||.||    |..:.:|.|:.|  :..|||.
  Fly  1087 DESERVPAEQ-LPPEVLHSPSDPEYHEPSKSGPEADVPHVPPHMPHARWETG--AAASTTAVPSL 1148

Human  1428 -GLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHSGNWSKCSRSCG-GGSSV--RDVQ 1488
             ..|.|:|                               |..|.||:||:.|| .||.:  |.|.
  Fly  1149 PNDGFVYR-------------------------------WMLGEWSQCSQECGAAGSGLQRRTVS 1182

Human  1489 C-------------------VDTRDLRPLRPFHC-QPGPAKPPAHRPCGAQPCLSWYTSSWRECS 1533
            |                   ||..:        | ..|...|...:.||.:.|..|....|..|.
  Fly  1183 CQRAAKATSSGSTSDTENNVVDNSE--------CFAHGLELPEFFQSCGNEACPQWSKGDWTPCQ 1239

Human  1534 EA-CGG---GEQQRLVTCPEP-----GLCEEALRPNTTRPCNTHPCT-QWVVGPWGQCSGPCG-G 1587
            .: |.|   ..|:|.|||..|     .:|:|..||...:.|....|. .|.|.||.:|:.||| .
  Fly  1240 RSHCHGRNTAMQRREVTCRYPNGTEGSICDEYERPAMRQECYNERCEGVWRVEPWSECNAPCGRK 1304

Human  1588 GVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCE------PVEPPRLSLPTVRPGMS 1646
            |::.|:::||  ..|......:.|.|:..|...:.|.:..|:      |.:..|.|....|...:
  Fly  1305 GIKYRILQCV--WYGSRRPAGNVCKHQPRPAVMKVCKSPACQAQLSSSPAQLCRDSSRYCRNARA 1367

Human  1647 LRLC 1650
            :.||
  Fly  1368 MGLC 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADAMTS7	XP_005254194.1	Pep_M12B_propep	68..183	CDD:279848
		Reprolysin	242..452	CDD:279729
		ZnMc_ADAMTS_like	242..449	CDD:239801
		ADAM_CR	<474..530	CDD:301627
		TSP1	541..593	CDD:214559	22/51 (43%)
		ADAM_spacer1	699..809	CDD:283607	0/109 (0%)
		TSP1	825..880	CDD:214559	16/55 (29%)
		TSP1	946..994	CDD:214559	20/51 (39%)
		TSP1	1466..1521	CDD:214559	20/77 (26%)
		TSP1	1570..1629	CDD:214559	18/60 (30%)
nolo	NP_001036374.1	TSP1	78..124	CDD:214559	22/51 (43%)
		TSP1	546..600	CDD:214559	5/53 (9%)
		TSP1	750..807	CDD:214559	11/56 (20%)
		IGc2	845..902	CDD:197706	7/57 (12%)
		PLAC	1355..1384	CDD:285849	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810