DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADAMTS7 and AdamTS-B

DIOPT Version :9

Sequence 1:XP_005254194.1 Gene:ADAMTS7 / 11173 HGNCID:223 Length:1689 Species:Homo sapiens
Sequence 2:NP_572247.2 Gene:AdamTS-B / 31490 FlyBaseID:FBgn0029791 Length:1023 Species:Drosophila melanogaster


Alignment Length:1023 Identity:371/1023 - (36%)
Similarity:517/1023 - (50%) Gaps:164/1023 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    36 ATEGRAALDIVHPVRVDAGGSFLSYEL-------WPRALRKRDVSVRRDAPA---FYELQYRGRE 90
            |.||:    :|.|.||...|:|::::|       ..|..::|.::...|..|   ...|......
  Fly    43 AGEGQ----LVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANET 103

Human    91 LRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGV 155
            |...|.|:.:.|||..|.|..||....|:.:......||..|:|:......  .|||.|.||.|.
  Fly   104 LHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATN--VAISTCAGLVGH 166

Human   156 FQLSNEDYFIEPLDSAPARPGHAQPHVVY------------KRQAPERLAQRGDSSAPSTCGVQV 208
            .:.:..:|||||.......|.:..||||:            ||...:|..:.|..:..|.||.: 
  Fly   167 IRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTR- 230

Human   209 YPELESRRERWEQRQQWRR---------PRLRRLH------------------------------ 234
                |.|| |.|.|.:|:.         .::||.|                              
  Fly   231 ----EPRR-RMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYE 290

Human   235 ---------------QRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIG 284
                           :||:|..:.||||:||||.|..:|  ..:..|:|||||||:.|:.|||||
  Fly   291 TQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIG 353

Human   285 NPIHITIVRLVLLEDEEEDLK--ITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLC 347
            |.|.|.:||::.|::||..|:  :|.:|...|..||.||..:|...:..|.|||.|||:|||::|
  Fly   354 NSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNIC 418

Human   348 AAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEP-VGKR 411
            |   ..|.||||::|.|||:|.:|||:|||.|:.|:.|:.|||||:||:.||.:...|.| ||..
  Fly   419 A---NNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPI 480

Human   412 PFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAK-DIIDFPSVPPGVLYDVSHQCR 475
            ..||:|....|...:.||.|||:|||.|||:|.|.||||||.. |..::....||:.|:...|||
  Fly   481 VHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCR 545

Human   476 LQY--------GAYSAFCEDMDNVCHTLWCSVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGF 532
            ||:        ||    |......|.||||.|...|.:.:.....||.||.||||.:|:||.   
  Fly   546 LQFNLTTDSEVGA----CSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVR--- 603

Human   533 RPE--AVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAG 595
            |.|  ||:|||..||.||.||||||.||.:.:|:|..|.|...|.:|:|||||:::|..:.|||.
  Fly   604 REELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAE 668

Human   596 RPSFRHVQCSHFDAMLYKGQLHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRAS 660
            .||||..||:.||.:.|:|..:.|:|..:..|||:|.|...::.........|:|||||  ...:
  Fly   669 EPSFRAQQCARFDNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPC--TLGT 731

Human   661 RDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEE---AEGLGYVDVGLIPAGA 722
            .::||:||||.||||:.:||...:||||||.|:|..|..|..|:.:   |:...||::..|||.|
  Fly   732 NNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARA 796

Human   723 REIRIQEVAEAANFLALRSED-PEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLTSPGPTK 786
            |.|.|:|:|.:.:|||:.:.| .::::|||...|...|::::||....|.|....|.:|.|.|.:
  Fly   797 RHILIRELANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQ 861

Human   787 EPVWIQLLFQ--ESNPGVHYEYT---IHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNV 846
            ..:.:..:.:  |||.|:.||:|   ::..||..       |.|....||.|:.:||.|||.:. 
  Fly   862 HSISLYAIVRGNESNAGIFYEFTLPALNVTAGRQ-------FQWRLSNWTACSASCGGGVQHRE- 918

Human   847 YCLERQAGPVDEEHCDPLG------------RPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGG 899
                    |:.:|:...||            ||..|.|.|.:|||||.||.|.||.|..:|.|.|
  Fly   919 --------PICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVG 975

Human   900 L-----SRRAVLCIRSVGLDEQSALEPPA-CEHLPRPPTETPCNRHVP 941
            .     .||:|:|     |||...:...| |.||.:|....||...:|
  Fly   976 FVAPPQRRRSVVC-----LDEHDVVVADAECGHLQKPAEMEPCESSLP 1018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADAMTS7XP_005254194.1 Pep_M12B_propep 68..183 CDD:279848 34/117 (29%)
Reprolysin 242..452 CDD:279729 106/212 (50%)
ZnMc_ADAMTS_like 242..449 CDD:239801 103/209 (49%)
ADAM_CR <474..530 CDD:301627 25/63 (40%)
TSP1 541..593 CDD:214559 25/51 (49%)
ADAM_spacer1 699..809 CDD:283607 38/118 (32%)
TSP1 825..880 CDD:214559 20/66 (30%)
TSP1 946..994 CDD:214559
TSP1 1466..1521 CDD:214559
TSP1 1570..1629 CDD:214559
AdamTS-BNP_572247.2 Pep_M12B_propep 78..194 CDD:279848 34/117 (29%)
ZnMc_ADAMTS_like 314..518 CDD:239801 103/208 (50%)
Reprolysin 315..521 CDD:279729 106/210 (50%)
ADAM_CR <558..602 CDD:301627 18/47 (38%)
TSP1 614..666 CDD:214559 25/51 (49%)
ADAM_spacer1 773..886 CDD:283607 37/112 (33%)
TSP1 901..956 CDD:214559 19/63 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 217 1.000 Domainoid score I2674
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H22803
Inparanoid 1 1.050 636 1.000 Inparanoid score I829
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 1 1.000 - - FOG0001196
OrthoInspector 1 1.000 - - otm40606
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - LDO PTHR13723
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5231
SonicParanoid 1 1.000 - - X2816
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.860

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