Protein Alignment LDB3 and ldb3a

DIOPT Version :10

• Sequence 1: NP_001165081.1
• Gene: LDB3 / 11155
• HGNCID: 15710
• Length: 732
• Species: Homo sapiens
• Sequence 2: NP_001417805.2
• Gene: ldb3a / 794339
• ZFINID: ZDB-GENE-040121-6
• Length: 649
• Species: Danio rerio
• Alignment Length: 774
• Identity: 379/774 - (48%)
• Similarity: 448/774 - (57%)
• Gaps: 170/774 - (21%)

Human     2 SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQ 66
            ||:|:|:||.|||||||||||||||||:||||||||||.|.|.|||::||||||:||.|||||||
Zfish     3 SYNVSLSGPPPWGFRLQGGKDFNMPLTVSRITPGSKAASSNLIQGDIIVAIDGVSTDGMTHLEAQ 67

Human    67 NKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSPEARASPG 131
            ||||||::||:||:|:||||.|:....|.:::|:||||||||..:..||:|   |.|.|..:...
Zfish    68 NKIKSANFNLALTMQRSKRPTPVPIATPRIESPMPVIPHQKDHPVQINGAL---SSSAETNSCKN 129

Human   132 TPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGPKALPGSSQ-PRQY 195
            |          ||::|  |..||..|.|.|.            :|  .|..|:....|.| .:||
Zfish   130 T----------SPSYS--SVLSSSGETSVPA------------QG--HLAAPRDKSSSRQKSQQY 168

Human   196 NNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGG-----ADYQERFNP------SALKDSALST 249
            |:||||||||||||||.:.:   |.|.||.|:..|     |.......|      :||.:..||
Zfish   169 NSPIGLYSAETLREMAMLQE---RAKGSGSGMTSGSAAEHAPVSTSIAPVCPPTMAALPNQLLS- 229

Human   250 HKPI--------EVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSGSLPIKDLA 306
             :|:        ||:       :|..|  |.:..||....|...:....:..|.:|...|::...
Zfish   230 -EPLIANQAPEPEVE-------LIPEQ--TTVPSYSLQTSMGYTSQYKTSISSSYSQPPPMQQPP 284

Human   307 VDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRPQAS 371
            :....|:.|.....|..|.........:...:|.           ...||.|
Zfish   285 LMQQPPLMQQPPLMQQPPPMHQHPHMHQPPPMQQ-----------PPLMQQP------------- 325

Human   372 SYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTP 436
                      .|..|:|. :.|..| |.|:||:||:|.|:.|                   |..|
Zfish   326 ----------PPMQHSSI-QIPVGP-PPPKVVSTATIMPASY-------------------PAGP 359

Human   437 SPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSF 501
            :|||.....|||                   |.|||   ||       .||..::||||||||:|
Zfish   360 APAPPMVHKPAP-------------------PPPAP---PA-------APASSSNRPPWVTDDNF 395

Human   502 SQKFAPGKST--TSISKQTLPRG----------------GPAYTPAGP-----QVPPLARGTVQR 543
            :|||.|.|.|  |:|..|.||:.                .||:.||.|     ..||:|||..||
Zfish   396 AQKFDPSKPTPNTNIKVQPLPQAAPPPPSIISNPVPAAPSPAFNPAPPPFNPAPFPPVARGVAQR 460

Human   544 AERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYE 608
            ||||.||:|||||..|||:||||||||:|||||||||.|.||.||||||.|||||||||||.|||
Zfish   461 AERFAASNRTPLCATCNNIIRGPFLVALGRSWHPEEFNCHYCHTSLADVSFVEEQNNVYCENCYE 525

Human   609 QFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTK 673
            :||||.||:|:|||||||||||||||||||||||||.||||||||||||||||||||||.|||||
Zfish   526 EFFAPTCARCSTKIMGEVMHALRQTWHTTCFVCAACGKPFGNSLFHMEDGEPYCEKDYIALFSTK 590

Human   674 CHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL 732
            |||||||||||||||||||||||||||:||||||||||||||||||:||||||||.||:
Zfish   591 CHGCDFPVEAGDKFIEALGHTWHDTCFVCAVCHVNLEGQPFYSKKDKPLCKKHAHAINV 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LDB3	NP_001165081.1	PDZ_PDLIM-like	4..82	CDD:467235	61/77 (79%)
		ZM	189..214	CDD:128974	19/25 (76%)
		DUF4749	263..365	CDD:464948	17/101 (17%)
		PHA03247	<387..554	CDD:223021	67/189 (35%)
		LIM1_ZASP_Cypher	556..607	CDD:188838	41/50 (82%)
		LIM2_Enigma_like	615..666	CDD:188748	47/50 (94%)
		LIM3_Enigma_like	674..727	CDD:188749	50/52 (96%)
ldb3a	NP_001417805.2	None