DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDR45 and HSV2

DIOPT Version :10

Sequence 1:NP_009006.2 Gene:WDR45 / 11152 HGNCID:28912 Length:361 Species:Homo sapiens
Sequence 2:NP_011739.1 Gene:HSV2 / 853138 SGDID:S000003455 Length:448 Species:Saccharomyces cerevisiae


Alignment Length:387 Identity:128/387 - (33%)
Similarity:192/387 - (49%) Gaps:66/387 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    11 SLRFNQDQSCFCCAMETGVRIYNVEPLMEK-------GHLDHEQVGSMGLVEMLHRSNLLALVGG 68
            |:.||||.|||..|:|.|.||:|.:||..|       ...:..:...:|...||:|:|.:|||||
Yeast    21 SVSFNQDDSCFSVALENGFRIFNTDPLTSKLSKTFKESATNQSRGTGIGYTRMLYRTNYIALVGG 85

Human    69 GSSPKFSEISAVLIWDDAREGKDSKEKLVLEF-TFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDN 132
            |..|:.: ::.::||||..:    ||.:.|:| :..|.|...|:.   ||:||:|.|.::.|..|
Yeast    86 GKRPRHA-LNKLIIWDDLLQ----KETITLKFMSSIKDVFLSRIH---IVVVLENTIEIFQFQTN 142

Human   133 PRKLFE-FDTRDNPKGLCD--LCPS--LEKQ----------LLVFPGHKC-GSLQLVDLASTK-- 179
            |:::.. .|.  .|.|..|  :|.|  |:.|          ::.||.:|| |.:|:.||:..|  
Yeast   143 PQRICPILDI--PPNGSVDYVVCSSKHLQSQASQSQSKILEIIAFPSNKCVGQIQVADLSQIKYN 205

Human   180 ---PGTSSAPFT--INAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPA 239
               |..|:...|  |.||::.|..|.||:.||:||:.|.:|||||:|.|.:...:.|.|||.|.|
Yeast   206 SQNPKESALLPTSIIKAHKNPIKLVRLNRQGTMVATCSVQGTLIRIFSTHNGTLIKEFRRGVDKA 270

Human   240 TLYCINFSHDSSFLCASSDKGTVHIFALKDT-----------RLNRRS-ALARVGKVGPMIGQYV 292
            .:|.::||.:.|.|...|:|.|:|||.:.:|           |.|..| .|......|....:|:
Yeast   271 DIYEMSFSPNGSKLAVLSNKQTLHIFQIFETTNTETNTPDHSRANGSSHPLKNYIPKGLWRPKYL 335

Human   293 DSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHK----YVFTPDGNCNREAFD 350
            ||.||:.:  ...::....|...:.|.:|..      |..|:|    ..:..|.| |||..|
Yeast   336 DSVWSICN--AHLKNPIFDAHRNDNSGDVTH------DNEFYKDRCRIGWCQDSN-NREQDD 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR45NP_009006.2 WD 1 1..34 13/22 (59%)
WD40 8..265 CDD:475233 103/284 (36%)
WD 3 93..129 13/36 (36%)
WD 4 134..175 14/56 (25%)
WD40 <168..>275 CDD:441893 47/124 (38%)
WD 5 184..223 19/40 (48%)
WD40 repeat 197..233 CDD:293791 16/35 (46%)
WD 6 228..267 17/38 (45%)
L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8 232..235 1/2 (50%)
WD 7 285..330 9/44 (20%)
HSV2NP_011739.1 WD40 <220..>296 CDD:441893 34/75 (45%)
WD40 repeat 228..267 CDD:293791 18/38 (47%)
WD40 repeat 272..298 CDD:293791 11/25 (44%)

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