Protein Alignment WDR45 and Wdr45

DIOPT Version :10

• Sequence 1: NP_009006.2
• Gene: WDR45 / 11152
• HGNCID: 28912
• Length: 361
• Species: Homo sapiens
• Sequence 2: NP_001413213.1
• Gene: Wdr45 / 54636
• MGIID: 1859606
• Length: 368
• Species: Mus musculus
• Alignment Length: 369
• Identity: 352/369 - (95%)
• Similarity: 359/369 - (97%)
• Gaps: 9/369 - (2%)

Human     1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLAL 65
            ||||||||||||.|||||||||||||||||||||||||||||||||||||:||||||||||||||
Mouse     1 MTQQPLRGVTSLHFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSVGLVEMLHRSNLLAL 65

Human    66 VGGGSSPKFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFP 130
            ||||||||||||| ||||||||||||||:|||||||||||||:||||||||||||:|||||||||
Mouse    66 VGGGSSPKFSEIS-VLIWDDAREGKDSKDKLVLEFTFTKPVLAVRMRHDKIVIVLRNRIYVYSFP 129

Human   131 DNPRKLFEFDTRDNPKG--------LCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPF 187
            |:|||||||||||||||        ||||||||||||||||||||||||||||||||||||||||
Mouse   130 DSPRKLFEFDTRDNPKGEKTQICRWLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPF 194

Human   188 TINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSF 252
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   195 TINAHQSDVACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSF 259

Human   253 LCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNT 317
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   260 LCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNT 324

Human   318 SKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF 361
            |||||||||||||||||||||||||||||||||||||||||:||
Mouse   325 SKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDEDF 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR45	NP_009006.2	WD 1	1..34		31/32 (97%)
		WD40	8..265	CDD:475233	248/264 (94%)
		WD 3	93..129		32/35 (91%)
		WD 4	134..175		40/48 (83%)
		WD40	<168..>275	CDD:441893	105/106 (99%)
		WD 5	184..223		37/38 (97%)
		WD40 repeat	197..233	CDD:293791	35/35 (100%)
		WD 6	228..267		38/38 (100%)
		L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8	232..235		2/2 (100%)
		WD 7	285..330		44/44 (100%)
Wdr45	NP_001413213.1	WD40	8..272	CDD:475233	248/264 (94%)
		WD40 repeat	156..187	CDD:293791	30/30 (100%)
		WD40	<175..>279	CDD:441893	102/103 (99%)
		WD40 repeat	204..240	CDD:293791	35/35 (100%)