DRSC/TRiP Functional Genomics Resources

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Protein Alignment WDR45 and wdr45

DIOPT Version :10

Sequence 1:NP_009006.2 Gene:WDR45 / 11152 HGNCID:28912 Length:361 Species:Homo sapiens
Sequence 2:XP_012812316.2 Gene:wdr45 / 496788 XenbaseID:XB-GENE-972376 Length:355 Species:Xenopus tropicalis


Alignment Length:361 Identity:314/361 - (86%)
Similarity:341/361 - (94%) Gaps:6/361 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLAL 65
            |.||  |||..||||||||||||||||||||:|:||||||||||.|||||:|.||||||.|||||
 Frog     1 MAQQ--RGVNGLRFNQDQSCFCCAMETGVRIFNIEPLMEKGHLDQEQVGSVGQVEMLHRCNLLAL 63

Human    66 VGGGSSPKFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFP 130
            |||||:||||:|| ||||||:|:|||   ||||||||||||||||:|.:||||.|||||||||||
 Frog    64 VGGGSNPKFSDIS-VLIWDDSRDGKD---KLVLEFTFTKPVLSVRLRSEKIVIALKNRIYVYSFP 124

Human   131 DNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSD 195
            |||.||||||||||||||||||||||||||:||||||||||||||.:.|||:||||||||||||:
 Frog   125 DNPTKLFEFDTRDNPKGLCDLCPSLEKQLLLFPGHKCGSLQLVDLCNAKPGSSSAPFTINAHQSE 189

Human   196 IACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKG 260
            :.|:::||.||:|||||:|||||||||||::|:||||||||||||||||||||||||||:|||||
 Frog   190 LGCLAVNQQGTLVASASRKGTLIRLFDTQTREQLVELRRGTDPATLYCINFSHDSSFLCSSSDKG 254

Human   261 TVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVI 325
            ||||||||||:|||||||||||||||||||||||||||||||||||||||||||:||||||||||
 Frog   255 TVHIFALKDTKLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGKNTSKNVNSVI 319

Human   326 AICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF 361
            |:|||||||||||||:||||||||||||||||||.|
 Frog   320 AVCVDGTFHKYVFTPEGNCNREAFDVYLDICDDDIF 355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WDR45NP_009006.2 WD 1 1..34 26/32 (81%)
WD40 8..265 CDD:475233 217/256 (85%)
WD 3 93..129 29/35 (83%)
WD 4 134..175 38/40 (95%)
WD40 <168..>275 CDD:441893 88/106 (83%)
WD 5 184..223 29/38 (76%)
WD40 repeat 197..233 CDD:293791 25/35 (71%)
WD 6 228..267 36/38 (95%)
L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8 232..235 2/2 (100%)
WD 7 285..330 42/44 (95%)
wdr45XP_012812316.2 WD40 6..259 CDD:475233 217/256 (85%)
WD40 repeat 101..137 CDD:293791 30/35 (86%)
WD40 repeat 142..182 CDD:293791 34/39 (87%)
WD40 <162..>269 CDD:441893 88/106 (83%)
WD40 repeat 191..227 CDD:293791 25/35 (71%)

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