Protein Alignment WDR45 and wdr45

DIOPT Version :10

• Sequence 1: NP_009006.2
• Gene: WDR45 / 11152
• HGNCID: 28912
• Length: 361
• Species: Homo sapiens
• Sequence 2: NP_956525.1
• Gene: wdr45 / 393200
• ZFINID: ZDB-GENE-040426-990
• Length: 358
• Species: Danio rerio
• Alignment Length: 361
• Identity: 324/361 - (89%)
• Similarity: 347/361 - (96%)
• Gaps: 3/361 - (0%)

Human     1 MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLAL 65
            |.||  |||.||:|||||||||||||||||||||||||||||||||||||:.|..|||||||||:
Zfish     1 MAQQ--RGVNSLQFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSIALCSMLHRSNLLAV 63

Human    66 VGGGSSPKFSEISAVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFP 130
            ||||.:||||||| |||||||||.:|.|:|||||||||||||:||||||||:|:|||||||||||
Zfish    64 VGGGVNPKFSEIS-VLIWDDAREVRDPKDKLVLEFTFTKPVLAVRMRHDKIIIILKNRIYVYSFP 127

Human   131 DNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSD 195
            |||.|||||||||||||||||||||||||||||||||||||||||::|||||||||||||||||:
Zfish   128 DNPVKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLSNTKPGTSSAPFTINAHQSE 192

Human   196 IACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKG 260
            |||::|||||:||||||:||||||||||.:::|||||||||||||||||||||||||||||||||
Zfish   193 IACLALNQPGSVVASASRKGTLIRLFDTTTRDKLVELRRGTDPATLYCINFSHDSSFLCASSDKG 257

Human   261 TVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVI 325
            ||||||||||:|||||||||||||||:||||||||||||:||||||.|||||||:||||||||||
Zfish   258 TVHIFALKDTKLNRRSALARVGKVGPVIGQYVDSQWSLANFTVPAECACICAFGKNTSKNVNSVI 322

Human   326 AICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF 361
            ||||||||||||||||||||||||||||||||||||
Zfish   323 AICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR45	NP_009006.2	WD 1	1..34		27/32 (84%)
		WD40	8..265	CDD:475233	227/256 (89%)
		WD 3	93..129		31/35 (89%)
		WD 4	134..175		39/40 (98%)
		WD40	<168..>275	CDD:441893	94/106 (89%)
		WD 5	184..223		33/38 (87%)
		WD40 repeat	197..233	CDD:293791	27/35 (77%)
		WD 6	228..267		38/38 (100%)
		L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8	232..235		2/2 (100%)
		WD 7	285..330		40/44 (91%)
wdr45	NP_956525.1	WD 1	2..40		34/39 (87%)
		WD40	6..262	CDD:475233	227/256 (89%)
		WD 2	188..228		30/39 (77%)
		WD40 repeat	194..231	CDD:293791	28/36 (78%)
		L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8	229..232		2/2 (100%)
		WD 3	233..272		37/38 (97%)