Protein Alignment WDR45 and epg-6

DIOPT Version :10

• Sequence 1: NP_009006.2
• Gene: WDR45 / 11152
• HGNCID: 28912
• Length: 361
• Species: Homo sapiens
• Sequence 2: NP_871659.1
• Gene: epg-6 / 189705
• WormBaseID: WBGene00012641
• Length: 388
• Species: Caenorhabditis elegans
• Alignment Length: 359
• Identity: 114/359 - (31%)
• Similarity: 195/359 - (54%)
• Gaps: 34/359 - (9%)

Human    17 DQSCFCCAMETGVRIYNVEPLMEKGHLDHE-QVGSMGLVEMLHRSNLLALVGGGSSPKFSEISAV 80
            |.|.|..|.:.|.::|.:.||..:.:.|:. :||.:.||:....|..:..|...:..:|:: :.:
 Worm    44 DHSAFAIADKDGFKMYQLNPLHFRMYKDYVIKVGPVRLVKQDGNSRRIIYVSALAGGRFAQ-NNL 107

Human    81 LIWDDAREGKDSKEKLVLEFTFTK---PVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTR 142
            :|:|.||..:      ..|.|...   |:.::.:..:::|.:..||::|:::||:.:::...|.|
 Worm   108 MIFDVARNEE------YFEITTPSRYGPITNIHVSPNRLVALNPNRMFVWTYPDDIKQIRSEDIR 166

Human   143 DNPKGLCDLC--PSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPG 205
            .||||:..:.  |:.....|.:||.|.||:|::.|.:.....|.:|..|.||.:|||.|:||..|
 Worm   167 SNPKGISAMSYDPTTAACYLAYPGFKTGSVQIMHLNALTARESKSPIVIEAHLTDIAQVALNCQG 231

Human   206 TVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDT 270
            |:||:.|.|||:||:||.::|..|.||||||..|.|.|:.||..||:|..:|||||:|:|.::|.
 Worm   232 TLVATGSTKGTVIRVFDARTKGPLYELRRGTVQAHLQCMAFSPCSSYLAVASDKGTLHMFGIRDA 296

Human   271 R-LNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACIC-AFGR--NTSKNVNSVIAICVDG 331
            . ..:::.|.|             |:.|.:...:..:...:. .||:  .|.||:.|:||||.|.
 Worm   297 EPQKKKNVLER-------------SRGSSSIVKIQLDRPVMAIGFGKIPETPKNLQSIIAICADA 348

Human   332 TFHKYVFTPD--GNCNRE--AFDVYLDICDDDDF 361
            |:.::.|..|  ||....  ::|..:::.:|..|
 Worm   349 TYWRHEFYKDNTGNFTSHFGSYDELIEVANDSSF 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDR45	NP_009006.2	WD 1	1..34		6/16 (38%)
		WD40	8..265	CDD:475233	89/253 (35%)
		WD 3	93..129		7/38 (18%)
		WD 4	134..175		14/42 (33%)
		WD40	<168..>275	CDD:441893	51/107 (48%)
		WD 5	184..223		21/38 (55%)
		WD40 repeat	197..233	CDD:293791	19/35 (54%)
		WD 6	228..267		22/38 (58%)
		L/FRRG motif. /evidence=ECO:0000250|UniProtKB:Q9Y4P8	232..235		2/2 (100%)
		WD 7	285..330		12/47 (26%)
epg-6	NP_871659.1	WD40 repeat	80..124	CDD:293791	11/50 (22%)
		WD40	<103..>300	CDD:441893	75/203 (37%)
		WD40 repeat	129..170	CDD:293791	10/40 (25%)
		WD40 repeat	173..216	CDD:293791	11/42 (26%)
		WD40 repeat	222..259	CDD:293791	20/36 (56%)
		WD40 repeat	267..306	CDD:293791	15/38 (39%)