DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HHLA2 and zormin

DIOPT Version :9

Sequence 1:XP_011510664.1 Gene:HHLA2 / 11148 HGNCID:4905 Length:425 Species:Homo sapiens
Sequence 2:NP_001261317.1 Gene:zormin / 2769001 FlyBaseID:FBgn0052311 Length:3664 Species:Drosophila melanogaster


Alignment Length:365 Identity:75/365 - (20%)
Similarity:121/365 - (33%) Gaps:94/365 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    78 SDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCYVG--------TAIQVITNKV 134
            :|......|.|.    :.||   ||.|:|.|..|.|.|:.:|||...        :|..::....
  Fly  1527 NDKCIDDSPDYV----ISYN---NGEATLKFEEVFLEDDAVYTCSASNPAGIEHCSASLIVEPLE 1584

Human   135 VLKVGVFLTPVMKYEKRNTNSFLICSVLSVYPRPIITWKMDNTPISENNME-ETGSLDSFSINSP 198
            ..::..|..|:.....|......:.:::...|||.:.|..:..|....:.: |.|.:   ::..|
  Fly  1585 PTELPSFKVPLSNAMARVGQKIKLEAIVGGIPRPEVYWLHNGKPFQPRDSKYEYGRV---TLIIP 1646

Human   199 LNITGSNSSYECTIENSLLKQTWTGRWTMKDGLHKMQSEHVSLSCQPVNDYFSPNQDFKVTWSRM 263
            ........||..:.:| |..:.:|                   ||..:.....||:   .:.|.|
  Fly  1647 QAYPNDAGSYVLSAKN-LAGEAYT-------------------SCNVIVKGRLPNE---TSDSEM 1688

Human   264 KSGTFSVL-AYYLSSSQNTIIN--------------ESRFSW--NKELINQSDFSMNLMDLNLSD 311
            .|....:. |.:|.....:|..              |....|  |:..:.:|      .|:.|..
  Fly  1689 ASDIEPIKPAVHLPLKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKES------ADVQLLF 1747

Human   312 SGEYLCNISSDEYTLLTIHTVHVEPSQETASHNKGLWILVPSAILAAFLLIWSVKCCRAQLEARR 376
            .|:....|..:.|             ||.|.|.|  .:.:.||..|:       ..|..::....
  Fly  1748 QGDRCSLIIQEVY-------------QEDAGHYK--VVAINSAGEAS-------SSCELKVTPLN 1790

Human   377 SRHPADGAQQERCCVPPG-----ERCPS--APDNGEENVV 409
            ...||..||.||..:|..     ||..|  ..|.||:.|:
  Fly  1791 QAEPATRAQAERQSLPKDSQPKFERLLSDVLADEGEQVVL 1830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HHLA2XP_011510664.1 Ig 47..125 CDD:325142 16/54 (30%)
Ig 137..215 CDD:325142 13/78 (17%)
V-set 231..330 CDD:311561 19/115 (17%)
zorminNP_001261317.1 SPEC 126..332 CDD:238103
SPEC <504..641 CDD:295325
COG1340 960..1298 CDD:224259
RILP-like <1190..1315 CDD:304877
MAP7 1233..1365 CDD:283355
I-set 1390..1479 CDD:254352
IGc2 1403..1469 CDD:197706
I-set 1491..1580 CDD:254352 17/59 (29%)
IGc2 1504..1570 CDD:197706 16/49 (33%)
I-set 1589..1675 CDD:254352 18/108 (17%)
Ig 1605..1675 CDD:299845 15/92 (16%)
I-set 1702..1786 CDD:254352 19/111 (17%)
Ig 1713..1786 CDD:299845 18/100 (18%)
I-set 1811..1902 CDD:254352 7/20 (35%)
Ig 1828..1892 CDD:143165 1/3 (33%)
I-set 1927..2015 CDD:254352
IGc2 1940..2005 CDD:197706
I-set 2142..2231 CDD:254352
Ig 2158..2231 CDD:299845
I-set 2238..2325 CDD:254352
Ig 2254..2324 CDD:299845
I-set 3566..3655 CDD:254352
Ig 3583..3650 CDD:143165
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.