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Protein Alignment HHLA2 and him-4

DIOPT Version :9

Sequence 1:	XP_011510664.1	Gene:	HHLA2 / 11148	HGNCID:	4905	Length:	425	Species:	Homo sapiens
Sequence 2:	NP_001024582.1	Gene:	him-4 / 181187	WormBaseID:	WBGene00001863	Length:	5198	Species:	Caenorhabditis elegans

Alignment Length:	415	Identity:	91/415 - (21%)
Similarity:	145/415 - (34%)	Gaps:	134/415 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    46 DIILPSSFER-GSEVVIHWKYQDSYKVHSYYKGSDHLESQDPRYA-NRTSLFYN----EIQNGNA 104
            |:::|....| |.::......|.|..:....:|.   .....|:. |.|:|.::    .:.:.:.
Worm  3946 DVLVPPEINRDGIDMSPRLPAQQSLTLQCLAQGK---PVPQMRWTLNGTALTHSTPGITVASDST 4007

Human   105 SLFFRRVSLLDEGIYTCYVGTAIQVITNKVVLKVGVFLTPVM-----KYEKRNTNSFLICSVLSV 164
            .:....|||.|:|:||||......  ::.::..|.|...||:     |.......:.:.| ::..
Worm  4008 FIQINNVSLSDKGVYTCYAENVAG--SDNLMYNVDVVQAPVISNGGTKQVIEGELAVIEC-LVEG 4069

Human   165 YPRPIITWKMDNTPISENNMEETG-------------------SLDS-----------------F 193
            ||.|.::|      :...|..|||                   ||||                 :
Worm  4070 YPAPQVSW------LRNGNRVETGVQGVRYVTDGRMLTIIEARSLDSGIYLCSATNEAGSAQQAY 4128

Human   194 SIN---SPLNIT----------GSNSSYECTIE---NSLLKQTWTGRWTMKDG-----------L 231
            ::.   ||..||          ||..|..|.:.   :.::..|..|. .:|||           |
Worm  4129 TLEVLVSPKIITSTPGVLTPSSGSKFSLPCAVRGYPDPIISWTLNGN-DIKDGENGHTIGADGTL 4192

Human   232 H--KMQSEHVSLSCQPVNDYFSPNQDFKVTWSRMKSGTFSVLAYYLSSSQNTIIN---------- 284
            |  |.:..|:...|...||..:...:|.|.         :::|..:|:|.|..||
Worm  4193 HIEKAEERHLIYECTAKNDAGADTLEFPVQ---------TIVAPKISTSGNRYINGSEGTETVIK 4248

Human   285 ------ESRFSWNK---------ELINQSDFSM-NLMDLNLSDSGEYLCNIS--SDEYTLLTIHT 331
                  .|.|||:|         .||...|:.: .::...|||.|||.|..:  :...|..|...
Worm  4249 CEIESESSEFSWSKNGVPLLPSNNLIFSEDYKLIKILSTRLSDQGEYSCTAANKAGNATQKTNLN 4313

Human   332 VHVEPS----QETASHNKG----LW 348
            |.|.|.    ..|...:||    ||
Worm  4314 VGVAPKIMERPRTQVVHKGDQVTLW 4338

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.