DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HHLA2 and hhla2b.2

DIOPT Version :9

Sequence 1:	XP_011510664.1	Gene:	HHLA2 / 11148	HGNCID:	4905	Length:	425	Species:	Homo sapiens
Sequence 2:	XP_009295721.1	Gene:	hhla2b.2 / 103909756	ZFINID:	ZDB-GENE-131121-425	Length:	372	Species:	Danio rerio

Alignment Length:	396	Identity:	104/396 - (26%)
Similarity:	175/396 - (44%)	Gaps:	67/396 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    12 ILITSLSGSQGIFPLAFFIYVPMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDSYKVHSYYK 76
            :||.:||.|.          .|.|....:  ..|..:||...:..|  :||| |:|...|||:|:
Zfish    11 LLIYTLSTSA----------TPDNRVTCV--YSEKCMLPCKSDYHS--IIHW-YKDKAPVHSFYR 60

Human    77 GSDHLESQDPRYANRTSLF-YNEIQNGNASLFFRRVSLLDEGIYTCYVGTAIQVITNKVVLKVGV 140
            .:|.|..|...|..||||. .:||..||.||..:.:.:.|||.|.||  ||.....::..:.|.|
Zfish    61 DADQLAHQSEEYKGRTSLLPASEINTGNVSLMLKNIKIQDEGRYKCY--TANDKSNHEQFVSVSV 123

Human   141 FLTPVMKYEKRNTNSFLICSVLSVYPRPIITWKMDNTPISE---NNMEETGSLDSFSINSPLNIT 202
             ..||........:..:.|:...|||.|.:.|...| |:::   ||..:|.. :..::.|.:.:.
Zfish   124 -EAPVRSLIITLVHETVTCTTSGVYPEPDVLWSSSN-PLAKDPLNNFSKTEE-NLSTVTSIIKVR 185

Human   203 GSNSSYE--CTIENSLLKQTWTGRWTMKDGLHKMQSEHVSLSCQPVN--DYFSPNQDFKVT---- 259
            ..|.:|:  |::.|   |.|.|.|:|   .:.:.|.       .||.  ||..|     ||
Zfish   186 AINETYKYNCSLIN---KDTGTIRYT---AILEQQE-------LPVTEFDYECP-----VTKGLD 232

Human   260 WSRMKSGTFSVLAYYLSSSQNTIINESRFSWNKEL-INQSDFSMNLMDLNLSDSGEYLCNISSDE 323
            ::.:.:.:.:|..|...:|    |||....|..:: .:....::.|..||...||:|..:.::.:
Zfish   233 YTLILNFSTTVFKYDTKAS----INEIADQWKPKITFHPETGTIKLSHLNEEQSGKYTLDCTTGQ 293

Human   324 YTLLTIHTVHVEPSQETASHNKGLWILVPSAILAAFLL--IWSVKC----CRAQLEARRSRHPAD 382
            |..:...|: ::...|.|....|  ::|...|:||.:|  |:..|.    |:.|   :.|.|.::
Zfish   294 YRHIVTATL-LQGGMEIAHIIIG--VIVSFIIIAAIVLVVIYRKKLQKIFCKKQ---KTSDHSSE 352

Human   383 GAQQER 388
            ..::::
Zfish   353 EMKEKQ 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HHLA2	XP_011510664.1	Ig	47..125	CDD:325142	32/78 (41%)
		Ig	137..215	CDD:325142	19/82 (23%)
		V-set	231..330	CDD:311561	22/105 (21%)
hhla2b.2	XP_009295721.1	Ig	34..107	CDD:299845	30/75 (40%)
		IG_like	36..123	CDD:214653	35/91 (38%)
		Ig	137..>186	CDD:299845	12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I31850
eggNOG	1	0.900	-	-		E1_2CFG9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG42419
OrthoDB	1	1.010	-	-		D1066670at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm28733
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	8	8.330