DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PWP1 and nclb

DIOPT Version :9

Sequence 1:	NP_008993.1	Gene:	PWP1 / 11137	HGNCID:	17015	Length:	501	Species:	Homo sapiens
Sequence 2:	NP_610623.1	Gene:	nclb / 36150	FlyBaseID:	FBgn0263510	Length:	459	Species:	Drosophila melanogaster

Alignment Length:	470	Identity:	171/470 - (36%)
Similarity:	266/470 - (56%)	Gaps:	34/470 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     7 VTCVAWVRCGVAKETPDKVELSKEEVKRLIAEAKEKLQEEGGGSDEEETGSPSEDGMQSARTQAR 71
            |..:.:|..||||:.|||:.|::.|:.|:|.:.:::|.||  ..|:.|.|..:|:..........
  Fly    14 VPALCFVPRGVAKDRPDKIVLTQAELARIIGDTQQELDEE--SDDDAEEGENAEEDQNDMDVDDH 76

Human    72 PREPLEDGDPEDDRTLDDDELAEYDLDKYDEEGDPDAETLGESLLGLTVYGSNDQDPYVTLKDTE 136
            .....|:.||:|          |:...:||.|.:.:..:|.      .:..:.:|.|    .:.|
  Fly    77 ADANSENRDPQD----------EFQFQEYDNEANANVTSLA------NIVDAGEQIP----DEDE 121

Human   137 QYEREDFLIKPSDNLIVCGRAEQDQCNLEVHVYNQEEDSFYVHHDILLSAYPLSVEWLNFDPSPD 201
            ..|.||.:||||||||:.|..:.|..::||.|:||||::.|.|||.||.::||.:||:|.| :..
  Fly   122 DSEAEDEVIKPSDNLILVGHVQDDAASMEVWVFNQEEEALYTHHDFLLPSFPLCIEWMNHD-AGS 185

Human   202 DSTGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNK 266
            :..||..|:|.|.|:|.||||||.|::||.|.||||.|:|:.|:      ..||.|||||||||.
  Fly   186 EKAGNMCAIGCMDPIITVWDLDIQDAIEPTFKLGSKGSRKQNKE------QYGHKDAVLDLSWNT 244

Human   267 LIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRS 331
            ...::|||.|.|.|||||||..|:|..::.....::|:|:|||.|||::::|..|..|.|:|||.
  Fly   245 NFEHILASGSVDQTVILWDMDEGQPHTTITAFGKQIQSLEFHPQEAQSILTGCADGYVRLFDCRD 309

Human   332 PD---ESHRMWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS-DKPIFTLNAHNDEISGLD 392
            .:   .|...|:..|::|:|.|:.....:|:..|:||.::..|.|| .:.::::.|||:||||:.
  Fly   310 AEGVNSSSIEWKVDGEVEKVLWHPTQTDYFIVGTNDGTLHYADKRSPGQLLWSVKAHNEEISGVC 374

Human   393 LSSQIKGCLVTASADKYVKIWDILGDRPSLVHSRDMKMGVLFCSSCCPDLPFIYAFGGQK-EGLR 456
            .::|....|.:.|.:..:|:|:..|.....|:..:..||.|.|...||:.|:..||||:| ....
  Fly   375 FNNQKPNLLTSTSTEGTLKVWNFDGTEAKHVYEHEFNMGRLQCMRQCPEDPYTLAFGGEKPPRCA 439

Human   457 VWDISTVSSVNEAFG 471
            :::|....:|...||
  Fly   440 IFNIKNSIAVRRTFG 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PWP1	NP_008993.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..89		11/50 (22%)
		WD 1	116..171		19/54 (35%)
		WD 2	177..222		21/44 (48%)
		WD 3	247..286		21/38 (55%)
		WD40	253..486	CDD:421866	83/224 (37%)
		WD40 repeat	259..295	CDD:293791	21/35 (60%)
		WD 4	290..329		13/38 (34%)
		WD40 repeat	303..342	CDD:293791	17/41 (41%)
		WD 5	334..372		10/37 (27%)
		WD40 repeat	345..382	CDD:293791	10/37 (27%)
		WD 6	376..415		12/38 (32%)
		WD 7	421..460		13/39 (33%)
		WD40 repeat	433..458	CDD:293791	10/25 (40%)
nclb	NP_610623.1	WD40	<189..426	CDD:330360	97/242 (40%)
		WD40 repeat	237..274	CDD:293791	21/36 (58%)
		WD40 repeat	282..319	CDD:293791	15/36 (42%)
		WD40 repeat	326..364	CDD:293791	10/37 (27%)
		WD40 repeat	415..454	CDD:293791	12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144705
Domainoid	1	1.000	161	1.000	Domainoid score	I4042
eggNOG	1	0.900	-	-		E1_KOG0270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5129
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2580
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53981
OrthoDB	1	1.010	-	-		D304388at33208
OrthoFinder	1	1.000	-	-		FOG0003681
OrthoInspector	1	1.000	-	-		oto88680
orthoMCL	1	0.900	-	-		OOG6_102416
Panther	1	1.100	-	-	LDO	PTHR14091
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1728
SonicParanoid	1	1.000	-	-		X2553
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800