DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAPN11 and CalpC

DIOPT Version :9

Sequence 1:	XP_011512576.1	Gene:	CAPN11 / 11131	HGNCID:	1478	Length:	744	Species:	Homo sapiens
Sequence 2:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	219/731 - (29%)
Similarity:	345/731 - (47%)	Gaps:	121/731 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    71 FEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINN------------ 123
            :|.:.:.|..|..|:|||.|||..||:.:....|.:     ..|:|..|:.::
  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFT-----FQWKRIMDLADSGSGAVAANSSAA 64

Human   124 PLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQW 188
            |:|:.:. :..|:..|.:||.||::.:|.|::...|.|||||..|:....: |:|.|::|..|:|
  Fly    65 PVFLNES-AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEW 127

Human   189 VNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQS 253
            |.|:|||||||.|.:|.|:.....:.||:||||||.|||.||||||..|:..:||.|..|||.:
  Fly   128 VEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGVVR- 191

Human   254 FQLQRP-------PQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDV 311
               |.|       ||.|..||......:.|...|..|...:..|.|.:.:||           :|
  Fly   192 ---QMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILV-----------NV 242

Human   312 HYR----GKMETLIR------------VRNPWG-RIEWNGAWSDSAREWEEVASDIQMQLLHKTE 359
            :||    .|::||:.            ...|:| :..:.|.||..::.||.|:...:.:|:.:..
  Fly   243 NYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLG 307

Human   360 DGEFWMSYQDFLNNFTLLEICNLTPDTLSGD--YKS---YWHTTFYEGSWRRGSSAGGCRNHPGT 419
            .||||:|:.||:..|:.:|:..|..:|.:.:  .||   :|....::|.|:||.:|||||||. :
  Fly   308 PGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNHE-S 371

Human   420 FWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQN 484
            |..|||..||:.:..|             .::||.|       ....:.:.|||.:|....|:
  Fly   372 FHINPQLLISVQDEQD-------------LVIALNQ-------HTAVEPKVIGFTMYTWDGEY-- 414

Human   485 IQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHS 549
            :....|:|:||..:..:..|: :.|:|.||....|..|.|::||:|:||..:|.|.:|:.   .:
  Fly   415 MLSECLQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRIL---GT 475

Human   550 ESWELD----------------EVNYAEQLQEEKV-SEDDMDQDFLHLFKIVAGEGKEIGVYELQ 597
            .|:.|.                :...||:....|| |....:..::.|    |.|.|.|..:||.
  Fly   476 GSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQL----ADENKTINCFELH 536

Human   598 RLLNRMAIKFKSFKTKG-FGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDH 661
            .||...   ..:...|| ..:|.||.:|.|.|:.|||::...:||.....||.|..:|:...::.
  Fly   537 ELLEAC---LPNDYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEK 598

Human   662 SGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKN 726
            :|.|.:..:|..:...|.:|:..:|..|:.||...|..:....|:|..:.|.|.|..|   ..||
  Fly   599 AGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQF---HLKN 660

Human   727 TGH---ICLSLEQWLQ 739
            .|.   |.:.|..|::
  Fly   661 YGQVNVIEVHLHDWIK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAPN11	XP_011512576.1	Peptidase_C2	85..381	CDD:279042	109/331 (33%)
		Calpain_III	395..549	CDD:279416	47/153 (31%)
		EFh	620..670	CDD:298682	16/49 (33%)
		EFh	651..706	CDD:298682	11/54 (20%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	112/343 (33%)
		Calpain_III	346..483	CDD:238132	49/163 (30%)
		FRQ1	<567..648	CDD:227455	21/80 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920