Protein Alignment KIF3A and CIN8

DIOPT Version :9

• Sequence 1: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_010853.2
• Gene: CIN8 / 856648
• SGDID: S000000787
• Length: 1000
• Species: Saccharomyces cerevisiae
• Alignment Length: 789
• Identity: 221/789 - (28%)
• Similarity: 353/789 - (44%)
• Gaps: 197/789 - (24%)

Human    14 NVKVVVRCRPLNEREKSMCYKQAVSVDEMRGT--ITVHKTD----SSNEPPKTFTFDTVFGPESK 72
            |:.|.||||..||||.||.....|:|.::.|:  |:::.|.    ::....|.:|.|.||||.:.
Yeast    36 NITVAVRCRGRNEREISMKSSVVVNVPDITGSKEISINTTGDTGITAQMNAKRYTVDKVFGPGAS 100

Human    73 QLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVR-----AIPELRGIIPNSFAHIFG 132
            |..:::..|.|:....::|||.|:..||.|.||||:||.|..     .:.:..||||.....:|.
Yeast   101 QDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEKLYNGELSDAAGIIPRVLLKLFD 165

Human   133 HIAKAEGDTRFLVRVSYLEIYNEEVRDLL-----GKDQT-------------------------- 166
            .:...:.|  ::|:.|::|:||||::|||     |...|
Yeast   166 TLELQQND--YVVKCSFIELYNEELKDLLDSNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNSA 228

Human   167 --------------------------QRLEVKERPDV---------------------------- 177
                                      :||..|..|:.
Yeast   229 SSSRSNSRNSSPRSLNDLTPKAALLRKRLRTKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNNA 293

Human   178 ---------------------GVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSH 221
                                 |:||::|..:.:.||.:...::..|.|:|.|.:|.||:.|||||
Yeast   294 SSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRSH 358

Human   222 AIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISA 286
            .|||||:....:    :...|:.|::||||||||...::||..||.|||..||.||.|||.||:|
Yeast   359 TIFTITLYKKHQ----DELFRISKMNLVDLAGSENINRSGALNQRAKEAGSINQSLLTLGRVINA 419

Human   287 LVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARI 351
            ||| ||.|:|:|.||||||||||||||:||.:.|.|.||....:||.|||.||::|||||||.::
Yeast   420 LVD-KSGHIPFRESKLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIKNKPQL 483

Human   352 NE-DPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRK------KRR 409
            .. ..||.|::....|:.::|..|     :|.....|.....|....:..|.|..|      ||.
Yeast   484 GSFIMKDILVKNITMELAKIKSDL-----LSTKSKEGIYMSQDHYKNLNSDLESYKNEVQECKRE 543

Human   410 GSSSSSSSDSTCSVIEKPLDKFLPNQAGKKKV-SPDKMIE--------MQAKIDEERKA------ 459
            ..|.:|.:    :::.|  ||.    ..|:.: |.:..||        ::|::|::.|.
Yeast   544 IESLTSKN----ALLVK--DKL----KSKETIQSQNCQIESLKTTIDHLRAQLDKQHKTEIEISD 598

Human   460 LETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLL 524
            ...||....|....|..:.:|||.||.:..:.|  :.:::..|:..:.     |.....:||.:|
Yeast   599 FNNKLQKLTEVMQMALHDYKKRELDLNQKFEMH--ITKEIKKLKSTLF-----LQLNTMQQESIL 656

Human   525 EESNME--LEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEM 587
            :|:|::  |:..:.....|.|.::||      .|..|....::...::.|...|    :..|.::
Yeast   657 QETNIQPNLDMIKNEVLTLMRTMQEK------AELMYKDCVKKILNESPKFFNV----VIEKIDI 711

Human   588 ADLQQEHQREIEGLLENIRQLSRE-LRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKCVAY 651
              ::.:.|:..:.:.||:..:|.| ..::..:.::|...::||::..:|.              .
Yeast   712 --IRVDFQKFYKNIAENLSDISEENNNMKQYLKNHFFKNNHQELLNRHVD--------------S 760

Human   652 TGNNMRKQT 660
            |..|:.|:|
Yeast   761 TYENIEKRT 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	150/447 (34%)
		SMC_prok_B	<450..>616	CDD:274008	35/174 (20%)
CIN8	NP_010853.2	KISc_BimC_Eg5	34..486	CDD:276815	155/456 (34%)
		Smc	<493..>772	CDD:224117	63/325 (19%)
		CCDC158	677..>928	CDD:318193	21/119 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I622
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.950