Protein Alignment KIF3A and sub

DIOPT Version :10

• Sequence 1: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_611260.1
• Gene: sub / 44870
• FlyBaseID: FBgn0003545
• Length: 628
• Species: Drosophila melanogaster
• Alignment Length: 606
• Identity: 166/606 - (27%)
• Similarity: 255/606 - (42%)
• Gaps: 171/606 - (28%)

Human    16 KVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSS----NEPPKTFTFDTVFGPESKQLDV 76
            :|.:|.||:.:..|:....:..:|     .||..|.||:    |...|.|.|.::|.....|.|:
  Fly    89 QVFLRLRPVKDASKAYIVSEEANV-----LITSCKVDSTSNNVNRMEKHFGFTSIFDSTVGQRDI 148

Human    77 YNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEG--VRAIPELRGIIPNSFAHIF-------- 131
            |:....|   .::|....||..||.:|:|||:|:.|  |||     ||||.:..:||
  Fly   149 YDTCVGP---KIMEEECVTIMTYGTSGSGKTYTLLGDDVRA-----GIIPRALENIFTIYQDTVF 205

Human   132 ---------GHI-------------------------------------------AKAEGDTRFL 144
                     |.|                                           .||..|...|
  Fly   206 RSPKLKLINGSIVFLQDDASLKELQIRKKLLDLCPDISAHHQRLKQVIDGDHMFETKASTDVSVL 270

Human   145 VRVSYLEIYNEEVRDLLG----KDQTQRLEVKERPDVG----VYIKDLSAYVVNNADDMDRIMTL 201
            |.||::|||||.|.|||.    :|:...:..|....||    |:||.|::..|.::::..|::.|
  Fly   271 VWVSFVEIYNELVYDLLAIPPKQDKLGEVPRKNLKIVGNKGHVFIKGLTSVFVTSSEEALRLLRL 335

Human   202 GHKNRSVGATNMNEHSSRSHAIFTITI-ECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQ 265
            |.:..:..:|::|.:|||||.:||:.| :.:..||     .........|||||||...||.:|.
  Fly   336 GQQRSTYASTSVNANSSRSHCVFTVDILKYNRSGI-----TTQSSYKFCDLAGSERVNNTGTSGL 395

Human   266 RLKEATKINLSLSTLGNVISA--LVDGKSTH--VPYRNSKLTRLLQDSLGGNSKTMMCANIGPAD 326
            |||||..||.||..||..:.|  .|..|...  :|||:||||.|||.:|.|..|..|...:.|.|
  Fly   396 RLKEAKNINTSLMVLGRCLDAASTVQKKKNADIIPYRDSKLTMLLQAALLGKEKLAMIVTVTPLD 460

Human   327 YNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKE----IEELKKKLEEGEEISGSDISG 387
            ..|:|.::.|.:|:.||||     |.::|   :::|.:..    :|..|....||.:.
  Fly   461 KYYEENLNVLNFASIAKNI-----IFKEP---VIKQHRVSYCGFMEFSKMSTCEGGDY------- 510

Human   388 SEEDDDEEGEVGEDGEKRKKRRGSSSSSSSDSTCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQAK 452
            ::|.:||...:..:.|:.|.                                    |.:::||..
  Fly   511 TKELEDENVRLQLEIEQLKY------------------------------------DHVLQMQLL 539

Human   453 IDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKA 517
            .::.|:.| |....|..:.||.:.| ::.||.||.||:|.:.:|.                 ::.
  Fly   540 EEKLRREL-TATYQEIIQNNKKQYE-DECEKKLLIAQRESEFMLS-----------------SQR 585

Human   518 EEQEKLLEESNMELEERRKRA 538
            ...|:.:|:...|:||.:..|
  Fly   586 RRYEEQIEDLKDEIEELKNPA 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	128/407 (31%)
		Smc	<451..>615	CDD:440809	21/88 (24%)
sub	NP_611260.1	KISc	89..477	CDD:276812	126/405 (31%)
		GBP_C	<512..603	CDD:293879	28/145 (19%)
		coiled coil	576..586	CDD:293879	2/26 (8%)
		coiled coil	592..603	CDD:293879	4/10 (40%)