Protein Alignment KIF3A and Klp98A

DIOPT Version :10

• Sequence 1: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_524532.2
• Gene: Klp98A / 43310
• FlyBaseID: FBgn0004387
• Length: 1265
• Species: Drosophila melanogaster
• Alignment Length: 859
• Identity: 240/859 - (27%)
• Similarity: 361/859 - (42%)
• Gaps: 272/859 - (31%)

Human    14 NVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHK----TDSSNEPPKTFTFDTVF------G 68
            ::||.||.||.|.||..|..:..:.::..:..:...:    .|:..:....||||..:      .
  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67

Human    69 PE-SKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFG 132
            |. :.|..||:.....::|...||||..:|||||||:||||||.|.   |...|:||.....:|.
  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT---PNNPGLIPRICEELFA 129

Human   133 HI-AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQT-QRLEVKERPDVGVYIKDLSAYVVNNADDM 195
            .: ...|..|.:....||||||||.|:|||....| ..|.|:|...:|.|:::||.:.|::.|::
  Fly   130 RMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEI 194

Human   196 DRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKT 260
            ...:..|:..|:..:||||:.|||||||||||. .....::......:.|:||||||||||...|
  Fly   195 QECIARGNAQRTTASTNMNDTSSRSHAIFTITF-VQAVFMNDMPSETVSKIHLVDLAGSERANAT 258

Human   261 GATGQRLKEATKINLSLSTLGNVISALVD------------------GKS---THVPYRNSKLTR 304
            |||||||||...||.||.|||:|||||.:                  |.|   .::|||:|.||.
  Fly   259 GATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTW 323

Human   305 LLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEE 369
            ||:|||||||||:|.|.:.|||.||.||:||||||||||||.||..:|||....|:|:.::||.:
  Fly   324 LLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINK 388

Human   370 LK--------------------KKLEEGEEI--------------------------SG------ 382
            ||                    :|.|..|::                          ||
  Fly   389 LKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKSGVGVVLD 453

Human   383 ----------SDIS---------------GSEEDD------------------------------ 392
                      :|::               |||:.|
  Fly   454 SEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLHP 518

Human   393 -------------DEEGEVGE----------------DGEKRKKRRGSSSS-----------SSS 417
                         ||..::.:                ..|..|.|:..|.|           ||.
  Fly   519 WPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMSRLSLITSSK 583

Human   418 DS--TCSVIEKPLDKFLPNQAGKKKVSPDKMI-----EMQAKIDEERKALET-----------KL 464
            ::  |||:.... |...|.:..:::..|.:.:     |:|   ||.||.|:|           ::
  Fly   584 ENLLTCSIYSDE-DGASPYKRPERQYYPQRPMSRDDPELQ---DENRKILDTIENALKQLNVERV 644

Human   465 DMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVG-------------GVDLLAK 516
            .|.::.:.|.|    |..::|::.:||....|:.|:..|:::|..             .:|::.:
  Fly   645 QMHDQYKTKVR----KLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIVCR 705

Human   517 --------------------AEEQEKL-----LEESNMELEERRKRAEQLRRELEEKEQERLDI- 555
                                |:|.::|     |:|..|::||    ...|..||..:..:.||:
  Fly   706 QISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEE----GTPLNDELLLQVSDSLDLF 766

Human   556 ------------EEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQR------EIEGLL 602
                        .|:...|.|:...|.:.|....|.:......|.::|.:.:|      |.|...
  Fly   767 AAQFIKDTVRRNNEEIRKLDEQIAEKERILNASTTKIAKVDETMLEIQAQLERLRLERAESEAES 831

Human   603 ENIRQLSRELRLQM 616
            :.:|...:.::||:
  Fly   832 QAMRAKKQNMKLQL 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	155/364 (43%)
		Smc	<451..>615	CDD:440809	43/231 (19%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	159/371 (43%)
		Kinesin_assoc	370..478	CDD:465047	15/107 (14%)
		FHA_KIF16	449..556	CDD:438760	7/106 (7%)
		SMC_N	624..>864	CDD:481474	44/230 (19%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784