Protein Alignment KIF3A and Kif19A

DIOPT Version :10

• Sequence 1: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 729
• Identity: 201/729 - (27%)
• Similarity: 330/729 - (45%)
• Gaps: 156/729 - (21%)

Human     8 KPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESK 72
            :|...:.:.|.||.||..|..: .|      ::.:.|...:: .|.....|:.:::|.||.....
  Fly    29 QPAQEERLVVAVRVRPSMEATE-RC------IEVISGGSLLY-DDGGKSRPRQYSYDHVFRENDS 85

Human    73 QLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGV----------RAIPELR------- 120
            |..||..|..|::..||.|.|..:||||.||:|||.||.|.          ||.|...
  Fly    86 QEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVS 150

Human   121 ----GIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYI 181
                |::..:...||.||..||..: ..|.:||||||||.:||||.......|....|.. .:.:
  Fly   151 SQDIGLMVRAIEDIFSHIESAEAYS-CRVSISYLEIYNELIRDLLNPGGPLELREDHRGQ-RITV 213

Human   182 KDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKL 246
            ..||....::..::..::..|:|.|::..|..|:.||||||:.:|.::....     :..:.|:|
  Fly   214 AGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTP-----LGTKQGRL 273

Human   247 HLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLG 311
            .|.|||||||..||...|:||:|...||.||..|||||:.| .|.:.:|.||:|||||||:::|.
  Fly   274 FLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGL-SGGARYVNYRDSKLTRLLKEALS 337

Human   312 GNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARIN---EDPKD-------ALLRQFQKE 366
            |..||:|.|::.|...:.|||.:||.||:||.:|..|.:.:   ::.||       :|:.:.:.|
  Fly   338 GRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQSLVSELRDE 402

Human   367 IEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRGSSSSSSSDSTCSVIEKPLDKF 431
            :..|:.|:......||:..:.:                      ::::|.|..|..
  Fly   403 VSRLRTKMLTERPRSGAAAAAA----------------------AAAASGSAGTAG--------- 436

Human   432 LPNQAGKKKVSPDKMIEMQAKIDEERKA----LETKLDMEEEERNKARAELEKREKDL----LKA 488
              :.||.:.|...         ||:||.    |..::.:..:::.|.|.:|.:.|..|    |.|
  Fly   437 --SGAGSEAVQEQ---------DEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDA 490

Human   489 QQEH------QSLLEKL------SALEKKVIVGGVDL------LAKAEEQ----EKLLEESNMEL 531
            :::|      |..:.||      ..:|.:   |.|.|      ||..|::    :::.|.:..||
  Fly   491 ERQHMIISHWQGRIGKLYDAMGDDDIESE---GSVALKNAWGELAAIEKETRRYKEIRERTEHEL 552

Human   532 EERRKRAEQLRRELEEK-----EQERL-------DIEEKYTSLQEEAQGKTKKLKKVWTMLMAAK 584
            |:.|::..:|..||.|:     |:|.|       ::|....|||.|...:..:|:         :
  Fly   553 EQCRQKGVKLEDELPERISSDEERELLALLCRVHELEADKVSLQAERLARQAELR---------R 608

Human   585 SEMADLQQEHQREI-EGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKC 648
            .::..|:.|.||.: |.::.:.|:|..|..:.       :|.:.:|:   |..:.::|....:
  Fly   609 RDLQLLRAERQRRLCEDIISSQRRLIEEGNVD-------LPDELREL---YGLYQQEIHAGVV-- 661

Human   649 VAYTGNNMRKQTPV 662
            ...|.|..||..|:
  Fly   662 TPSTSNYERKLPPI 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	126/352 (36%)
		Smc	<451..>615	CDD:440809	49/206 (24%)
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	126/351 (36%)
		SMC_prok_B	<393..672	CDD:274008	68/344 (20%)