Protein Alignment KIF3A and Klp68D

DIOPT Version :10

• Sequence 1: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_524029.2
• Gene: Klp68D / 39332
• FlyBaseID: FBgn0004381
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 298/739 - (40%)
• Similarity: 447/739 - (60%)
• Gaps: 77/739 - (10%)

Human     6 SEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHK-TDSSNEPPKTFTFDTVFGP 69
            |:.|..|  |:|||||||::.||:|....:.|:|...||.:.:.. .|.:.|..|.||:|..:..
  Fly    13 SQTPNEC--VQVVVRCRPMSNRERSERSPEVVNVYPNRGVVELQNVVDGNKEQRKVFTYDAAYDA 75

Human    70 ESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHI 134
            .:.|..:|:....|::.|||||:||.|||||||||||||||||||...||.||||.:|..|:.||
  Fly    76 SATQTTLYHEVVFPLVSSVLEGFNGCIFAYGQTGTGKTFTMEGVRGNDELMGIIPRTFEQIWLHI 140

Human   135 AKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIM 199
            .:.| :.:|||.|||||||.||:|||| |..::.|||:||.. |||:.:|.|....:.:||.::|
  Fly   141 NRTE-NFQFLVDVSYLEIYMEELRDLL-KPNSKHLEVRERGS-GVYVPNLHAINCKSVEDMIKVM 202

Human   200 TLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATG 264
            .:|:|||:||.||||||||||||||.|.||..:...:   .:::|||:|:||||||||:||||:.
  Fly   203 QVGNKNRTVGFTNMNEHSSRSHAIFMIKIEMCDTETN---TIKVGKLNLIDLAGSERQSKTGASA 264

Human   265 QRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNY 329
            :|||||:||||:||:||||||||.: .|.|||||:|||||||||||||||||:|.|||||::|||
  Fly   265 ERLKEASKINLALSSLGNVISALAE-SSPHVPYRDSKLTRLLQDSLGGNSKTIMIANIGPSNYNY 328

Human   330 DETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDE 394
            :||::|||||:|||:|:|:...||||:||.|:::|:|||.||:            :.|.::....
  Fly   329 NETLTTLRYASRAKSIQNQPIKNEDPQDAKLKEYQEEIERLKR------------LIGPQQQQRS 381

Human   395 EGEVGEDGEKRKK-RRGSSSSSSSDS-TCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQAKIDEER 457
            |.:|....::.|| ::.:.:...||| ..|.||:|::.                       |.:.
  Fly   382 EKQVTAKKQRVKKPKKETVTKEMSDSLQVSTIEQPVED-----------------------DSDP 423

Human   458 KALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEK 522
            :..|::.|.|.|      ||:.|..::|.:.:.|:..|..||:.||.:::.||.:||....|::.
  Fly   424 EGAESESDKENE------AEVAKSNEELERERVENSKLAAKLAELEGQLVRGGKNLLDTYSERQI 482

Human   523 LLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEM 587
            .||:..:|:.||:||..:::::||.:|:..|:|.|:..||::|.:.|.:||.|.:...:|.:.|:
  Fly   483 ELEKKLVEIAERKKREIEIQQQLELQEETTLEIRERNVSLEQEVELKKRKLSKCYAKYLALQQEL 547

Human   588 ADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKCVAYT 652
            .|.:.:|.:::..|.....:|.:||:.|:||||||:|.:.::.:.....::|:..||:...::..
  Fly   548 NDCKSDHNQDLRELEMAQNELVKELKRQLLIIDNFVPIEVKQRLYTQAKYDEEQEEWKFSSMSLP 612

Human   653 -----GNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESLRQSL---------MKLERP-RTSKG 702
                 ......:.||...:.:.|    .|...|...:.:...||         .:||.| ||::.
  Fly   613 TPPGGDGKFSSKRPVSHPQRRRP----TSEYALQEAKSNSPSSLRFKSENIVNYELEMPCRTTQE 673

Human   703 KARPKTGRRKRSAKPETVIDSLLQ 726
            ...||.     ||..:.|:...:|
  Fly   674 YRTPKV-----SASLQAVLAQAMQ 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	191/332 (58%)
		Smc	<451..>615	CDD:440809	48/163 (29%)
Klp68D	NP_524029.2	KISc	20..351	CDD:214526	193/337 (57%)
		Smc	<431..>580	CDD:440809	49/154 (32%)