Protein Alignment KIF3A and Khc

DIOPT Version :9

• Sequence 1: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Alignment Length: 755
• Identity: 244/755 - (32%)
• Similarity: 380/755 - (50%)
• Gaps: 117/755 - (15%)

Human    13 DNVKVVVRCRPLNEREKSMCYKQAV----SVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQ 73
            |::|||.|.||||:.|:....|..|    :|:|  ..|::        ..|.:.||.||.|.:.|
  Fly    11 DSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEE--NCISI--------AGKVYLFDKVFKPNASQ 65

Human    74 LDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAE 138
            ..|||..|:.|:..||.||||||||||||.:|||.|||||......:||||.....||.||...|
  Fly    66 EKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAME 130

Human   139 GDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGH 203
            .:..|.::|||.|||.:::||||...:. .|.|.|..:...|:|..:...|::.:|:..::..|.
  Fly   131 VNLEFHIKVSYYEIYMDKIRDLLDVSKV-NLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGK 194

Human   204 KNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLK 268
            .||.:..|||||||||||::|.|.::  ::.:: |.....|||:||||||||:.:||||.|..|.
  Fly   195 SNRHIAVTNMNEHSSRSHSVFLINVK--QENLE-NQKKLSGKLYLVDLAGSEKVSKTGAEGTVLD 256

Human   269 EATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETI 333
            ||..||.|||.||||||||.||..||:|||:|||||:||:|||||::|.:.....||.:|..||.
  Fly   257 EAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETK 321

Human   334 STLRYANRAKNIKNKARINED-PKDALLRQFQKEIEE---LKKKLEEGE-EI----SGSDISGSE 389
            |||.:..|||.:||...:||: ..:...|:::||.|:   ||.|:|:.| |:    :|..:...|
  Fly   322 STLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEE 386

Human   390 EDDDE----------EGEVGE----DGEKRKKRRGSSSSSSS---------DSTCSVIEKPLDKF 431
            :.:.|          |.|..:    :.....:|...::.|:|         .:.|..:.:.||
  Fly   387 QINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLD-- 449

Human   432 LPNQAGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLL 496
                      ..|:.|..|::..|:.|  |..::.||...| ||.|.|..:.::.:.|||::|..
  Fly   450 ----------DKDEEINQQSQYAEQLK--EQVMEQEELIAN-ARREYETLQSEMARIQQENESAK 501

Human   497 EKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTS 561
            |::.           ::|...||.....::.:.|::.:.|..:.|..||::|:........:...
  Fly   502 EEVK-----------EVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQ 555

Human   562 LQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRD 626
            |::.:..:.|::.::.|.|      :.||.:..|....|      :.|.:|::..|     ...|
  Fly   556 LKDMSSHQKKRITEMLTNL------LRDLGEVGQAIAPG------ESSIDLKMSAL-----AGTD 603

Human   627 YQEMIENYVHWNEDIGEW--QLKCVAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTE----- 684
            ..::.|::......|.:.  :.|.:|...:||..|....:||..: :|.||....|..::
  Fly   604 ASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISE-YEKDLGEYRLLISQHEARM 667

Human   685 ESLRQSLMKLERPRTSKGKARPKTGRRKRSAKPETVIDSL 724
            :||::|:.:.|              .:||:.  |..||||
  Fly   668 KSLQESMREAE--------------NKKRTL--EEQIDSL 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	156/335 (47%)
		SMC_prok_B	<450..>616	CDD:274008	35/165 (21%)
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	156/335 (47%)
		KISc	12..340	CDD:214526	157/341 (46%)
		Apolipoprotein	595..744	CDD:279749	26/119 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910