DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF3A and tea2

DIOPT Version :9

Sequence 1:	NP_001287720.1	Gene:	KIF3A / 11127	HGNCID:	6319	Length:	726	Species:	Homo sapiens
Sequence 2:	NP_596620.1	Gene:	tea2 / 2539857	PomBaseID:	SPBC1604.20c	Length:	628	Species:	Schizosaccharomyces pombe

Alignment Length:	522	Identity:	156/522 - (29%)
Similarity:	257/522 - (49%)	Gaps:	85/522 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    19 VRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARP 83
            :|.||:.:.:....:.:..:....|..|....:.||:...:.:.|:.|||.|||..|:|..:.:.
pombe   137 IRIRPIGKNQGVWSHGKLSNDPYGREYIRQQTSTSSSTIQQEYLFNNVFGMESKNYDIYKRSVKS 201

Human    84 IIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEGDTRFLVRVS 148
            ::.:|..||||.:||||.||||||::|:|....|   ||||.:...:|..:.....|..|.:|:|
pombe   202 VVRNVFSGYNGIVFAYGMTGTGKTYSMQGTENEP---GIIPLAMNDLFEMVENNSDDDTFQIRIS 263

Human   149 YLEIYNEEVRDLLG-KDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATN 212
            |||||||.:|||:| .|:..|  ::|.....|.:..|:..:|.:.:::.:::...:..|...||:
pombe   264 YLEIYNERIRDLIGNSDEEPR--IRENASGEVNVTPLTRVLVTSPEEVSQVIEQCNAIRKTAATD 326

Human   213 MNEHSSRSHAIFTITIECSEKGIDGN--MHV-RMGKLHLVDLAGSERQAKTGATGQRLKEATKIN 274
            .|.:|||||||..:.:      |..|  .|. ::..|.|||||||||   ..|..:|.||...||
pombe   327 FNTYSSRSHAILQVFL------IRNNPTAHTSQISSLSLVDLAGSER---ASAHHERRKEGAFIN 382

Human   275 LSLSTLGNVISAL-------VDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDET 332
            .||.|||.|||.|       :...|.|:|||.||||||||.||.|.|:..:.|.|.....:..||
pombe   383 KSLLTLGTVISRLSAAANPSLTSNSGHIPYRESKLTRLLQQSLSGQSQISLLATISIESNHTMET 447

Human   333 ISTLRYANRAKNIKNKAR------------------INEDPKD-----ALLRQFQKEIEE----- 369
            .:||::|:||:|:....|                  :.::.::     :|::|...::||
pombe   448 TNTLKFASRAQNLPQDIRQAEAVTNVQAELASLHSALEKNAQEVEYYASLVKQLTSDLEERDTYI 512

Human   370 --LKKKLEEGEEISGSDISGSEEDDDEEGEVG------EDGEK-------RKKRRGSSSSSSSDS 419
              |:.:..:|..||.:.:...|...|...|:.      :|.|:       .:|:|..:..:.|
pombe   513 AMLEAERSQGTAISRARLRMEELLSDHNFEIADLRDELQDKEQIIYALRYAQKQRDIADFNQS-- 575

Human   420 TCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKD 484
                    |.|| |::..||.|:      ..::...::.:.|||.::..:::.:::.:...:|..
pombe   576 --------LAKF-PHKILKKNVT------RGSRSSSDQFSNETKTEILPDDQQQSKKDSVTQETQ 625

Human   485 LL 486
            ||
pombe   626 LL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	125/336 (37%)
KIF3A	NP_001287720.1	SMC_prok_B	<450..>616	CDD:274008	6/37 (16%)
tea2	NP_596620.1	Motor_domain	133..460	CDD:277568	125/336 (37%)
tea2	NP_596620.1	Kinesin	138..459	CDD:278646	125/334 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001102
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910