Protein Alignment KIF3A and tea2

DIOPT Version :10

• Sequence 1: NP_001287720.1
• Gene: KIF3A / 11127
• HGNCID: 6319
• Length: 726
• Species: Homo sapiens
• Sequence 2: NP_596620.1
• Gene: tea2 / 2539857
• PomBaseID: SPBC1604.20C
• Length: 628
• Species: Schizosaccharomyces pombe
• Alignment Length: 522
• Identity: 156/522 - (29%)
• Similarity: 257/522 - (49%)
• Gaps: 85/522 - (16%)

Human    19 VRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARP 83
            :|.||:.:.:....:.:..:....|..|....:.||:...:.:.|:.|||.|||..|:|..:.:.
pombe   137 IRIRPIGKNQGVWSHGKLSNDPYGREYIRQQTSTSSSTIQQEYLFNNVFGMESKNYDIYKRSVKS 201

Human    84 IIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELRGIIPNSFAHIFGHIAKAEGDTRFLVRVS 148
            ::.:|..||||.:||||.||||||::|:|....|   ||||.:...:|..:.....|..|.:|:|
pombe   202 VVRNVFSGYNGIVFAYGMTGTGKTYSMQGTENEP---GIIPLAMNDLFEMVENNSDDDTFQIRIS 263

Human   149 YLEIYNEEVRDLLG-KDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATN 212
            |||||||.:|||:| .|:..|  ::|.....|.:..|:..:|.:.:::.:::...:..|...||:
pombe   264 YLEIYNERIRDLIGNSDEEPR--IRENASGEVNVTPLTRVLVTSPEEVSQVIEQCNAIRKTAATD 326

Human   213 MNEHSSRSHAIFTITIECSEKGIDGN--MHV-RMGKLHLVDLAGSERQAKTGATGQRLKEATKIN 274
            .|.:|||||||..:.:      |..|  .|. ::..|.|||||||||   ..|..:|.||...||
pombe   327 FNTYSSRSHAILQVFL------IRNNPTAHTSQISSLSLVDLAGSER---ASAHHERRKEGAFIN 382

Human   275 LSLSTLGNVISAL-------VDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDET 332
            .||.|||.|||.|       :...|.|:|||.||||||||.||.|.|:..:.|.|.....:..||
pombe   383 KSLLTLGTVISRLSAAANPSLTSNSGHIPYRESKLTRLLQQSLSGQSQISLLATISIESNHTMET 447

Human   333 ISTLRYANRAKNIKNKAR------------------INEDPKD-----ALLRQFQKEIEE----- 369
            .:||::|:||:|:....|                  :.::.::     :|::|...::||
pombe   448 TNTLKFASRAQNLPQDIRQAEAVTNVQAELASLHSALEKNAQEVEYYASLVKQLTSDLEERDTYI 512

Human   370 --LKKKLEEGEEISGSDISGSEEDDDEEGEVG------EDGEK-------RKKRRGSSSSSSSDS 419
              |:.:..:|..||.:.:...|...|...|:.      :|.|:       .:|:|..:..:.|
pombe   513 AMLEAERSQGTAISRARLRMEELLSDHNFEIADLRDELQDKEQIIYALRYAQKQRDIADFNQS-- 575

Human   420 TCSVIEKPLDKFLPNQAGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKD 484
                    |.|| |::..||.|:      ..::...::.:.|||.::..:::.:::.:...:|..
pombe   576 --------LAKF-PHKILKKNVT------RGSRSSSDQFSNETKTEILPDDQQQSKKDSVTQETQ 625

Human   485 LL 486
            ||
pombe   626 LL 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF3A	NP_001287720.1	KISc_KIF3	13..345	CDD:276822	125/336 (37%)
		Smc	<451..>615	CDD:440809	6/36 (17%)
tea2	NP_596620.1	KIP1	164..628	CDD:227392	152/495 (31%)