Protein Alignment FAF1 and casp

DIOPT Version :10

• Sequence 1: NP_008982.1
• Gene: FAF1 / 11124
• HGNCID: 3578
• Length: 650
• Species: Homo sapiens
• Sequence 2: NP_611080.1
• Gene: casp / 36769
• FlyBaseID: FBgn0034068
• Length: 695
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 244/710 - (34%)
• Similarity: 382/710 - (53%)
• Gaps: 76/710 - (10%)

Human     1 MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGP- 64
            |:.|.|.  .|..||:.|||:::.||.:.||..:|:||.|::.|||.|:..|.|.: ...:|.|
  Fly     1 MSENKDE--ALTSFQSITGIDDVGEAFSHLEAADWNLVEALSRVIPHEDAPLTSPH-PILVPEPP 62

Human    65 ---------AFNPASHPASAPTSSSSSAFRPVM------------------PSRQIV-------- 94
                     .|.|........||::|..|...:                  |:.|::
  Fly    63 ARNAVESTNGFRPPGFDEMPGTSNASGFFAAALQNQNQNLNLNQPHIQQRFPTSQLLAQLTSSIN 127

Human    95 -------ERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVED 152
                   .....::.|.:.:..:...:.|....||.::|:.:..|..:||.:..::||......|
  Fly   128 LDPASSQNNNQNVITFNIHFNQQLYQLRLPSEATVEQLKRKIFAETSVPVCRQAIRGWPPSKASD 192

Human   153 S----TVLKSLHLPKNNSLYV--LTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNF 211
            :    |.|.:|.|...|.|.:  ||.|   ....:....:.:.::::|.:.|.. |......|:.
  Fly   193 AQQLGTRLCNLDLSPENELILVDLTED---GFMDTEQDEVTQRVDKDFTIFIQF-ESDPPLTLSL 253

Human   212 SGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMCLAESGLSYPCHRLTV--GRRSSPAQT 274
            .|..|:||||.||:|:.|||||||.|.|||....:|: .||:||:.. .||..|  ..||:|..:
  Fly   254 PGRMTVQEVKMNVFDIKSIPVRHQEWTGWPNGCDNDT-TLAQSGIGL-SHRFAVRSTERSAPTNS 316

Human   275 REQSEEQITDVHMVSDSDGDDFEDATEFGVDDGEVFGMASSALRKSP---MMPENAENEGDALLQ 336
            .:.:...:..|.  |:|..|:|||||:|   :...:....|...:.|   ::|.:.::|.....|
  Fly   317 NQHNAFDVVTVD--SESSTDEFEDATDF---NNAEYIFTDSPPAQPPNRHLIPNDTDDEISGSTQ 376

Human   337 FTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIV 401
            |...:.:|||:..|.||:||||.|.|.|....|::||||||||||.:|:|:||||.|::..|||:
  Fly   377 FVENYKARYGEPCPEFFVGSLENAKQLACLRSAKERKLLAIYLHHGKSILSNVFCDQLMKHESII 441

Human   402 SYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKR---SSNEV 463
            ....:.|:.:.||:|.:||:..||:.......|..:.|.|..|.|:.|..:::...|   |:.||
  Fly   442 QTFKEKFVLYGWDMTYESNKDMFLSSLTACISSNASLTARNIKLDKLPAIMLVGKSRQLGSNCEV 506

Human   464 LNVIQGNTTVDELMMRLMAAMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLEA----DRA 524
            |:||.||..:|:|:.||:...|:|..|.|.:|:.||||.||:.||.|||.||:.:|:|    |.|
  Fly   507 LSVIHGNIGLDDLLTRLIETCEMFEEQLQVEIRQEDERAARDQVKAEQDMAYQETLQADMAKDAA 571

Human   525 KREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPKEENAEPVSKLRIRTPSGEFLERR 589
            ||:....::||:.|:|..|.|::..||:|||..:|:||.||.|:.. ..||:|:|.|:|:|||||
  Fly   572 KRQKEAAQLAERKRMESERAEEDARRESIRLVAQQSLPQEPSEQET-GTSKIRVRKPTGDFLERR 635

Human   590 FLASNKLQIVFDFVASKGFPWDEYKLLSTFPRRDVTQLDPNKSLLEVKLFPQETLFLEAK 649
            |..:|.||.:.:||.:.||..:||||:|::||||:|.::.:::|..:||:||||:.||.:
  Fly   636 FFINNNLQDLLNFVTANGFLIEEYKLISSWPRRDLTAIESSQTLESLKLYPQETVILEER 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FAF1	NP_008982.1	UBA_FAF1	14..46	CDD:270596	14/31 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..87		8/34 (24%)
		Ubl1_FAF1	100..172	CDD:340649	18/77 (23%)
		Ubl_FAF1	195..268	CDD:340576	31/74 (42%)
		UAS_FAF1	352..487	CDD:239288	58/137 (42%)
		Mitofilin	<490..>595	CDD:430783	51/108 (47%)
		UBX_UBXN3A	571..649	CDD:340469	38/77 (49%)
casp	NP_611080.1	UBA_FAF1	12..44	CDD:270596	14/31 (45%)
		Ubl1_FAF1	140..215	CDD:340649	17/74 (23%)
		Ubl2_FAF1	236..308	CDD:340650	32/74 (43%)
		UAS_FAF1	392..530	CDD:239288	58/137 (42%)
		tolA	<531..>600	CDD:236545	30/68 (44%)
		UBX_UBXN3A	616..695	CDD:340469	38/79 (48%)