DRSC/TRiP Functional Genomics Resources

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Protein Alignment FAF1 and Faf2

DIOPT Version :10

Sequence 1:NP_008982.1 Gene:FAF1 / 11124 HGNCID:3578 Length:650 Species:Homo sapiens
Sequence 2:NP_477388.1 Gene:Faf2 / 35129 FlyBaseID:FBgn0025608 Length:464 Species:Drosophila melanogaster


Alignment Length:350 Identity:97/350 - (27%)
Similarity:169/350 - (48%) Gaps:61/350 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   331 GDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNV--FCSQ 393
            || :::|..|:..||.: ||||:.|:...|..:|    .::.:.|.:|||.|.:...:|  ||..
  Fly   144 GD-VMKFIREYYERYPE-HPVFYQGTYAQALNDA----KQELRFLIVYLHKDPAKNPDVESFCRN 202

Human   394 MLCAESIVSYLSQNFITWAWDLTKDSNRARFLTMCNRHFGSVVAQTIRTQKTDQFPLFLIIMGKR 458
            .|.|.|::.|::.:.:.|..|:..........::..|.:.::|..::|..:       ::|:|: 
  Fly   203 TLSARSVIDYINTHTLLWGCDVATPEGYRVMQSITVRSYPTMVMISLRANR-------MMIVGR- 259

Human   459 SSNEVLNVIQGNTTVDELMMRLMA---AMEIFTAQQQEDIKDEDEREARENVKREQDEAYRLSLE 520
                    .:|:.|.:||:.||.:   |.|::.:|.:   .|..||...:.::|:|||||..||.
  Fly   260 --------FEGDCTPEELLRRLQSVTNANEVWLSQAR---ADRLERNFTQTLRRQQDEAYEQSLL 313

Human   521 ADRAKREAHERE-----MAEQFRLEQIRKEQEEEREAI---RLSLEQALPPEPKEENAEPVSKLR 577
            ||..|....:||     .||: .:||.|::.|..:|.|   ::.|...:|.||.   |:.|..:.
  Fly   314 ADEEKERQRQRERDAVRQAEE-AVEQARRDVELRKEEIARQKIELATLVPSEPA---ADAVGAIA 374

Human   578 I--RTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEYKLLSTFPRR---DVTQLDP-------- 629
            :  :.|||..|||||..::.:..|:.::.......||:::.:.||:|   ....||.        
  Fly   375 VVFKLPSGTRLERRFNQTDSVLDVYHYLFCHPDSPDEFEITTNFPKRVLFSKANLDAAGETGTAK 439

Human   630 ---NKSLLEVKLFPQETLF---LEA 648
               .|:|..|.|..:|.||   |||
  Fly   440 ETLTKTLQAVGLKNREVLFVNDLEA 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAF1NP_008982.1 UBA_FAF1 14..46 CDD:270596
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 62..87
Ubl1_FAF1 100..172 CDD:340649
Ubl_FAF1 195..268 CDD:340576
UAS_FAF1 352..487 CDD:239288 31/139 (22%)
Mitofilin <490..>595 CDD:430783 39/114 (34%)
UBX_UBXN3A 571..649 CDD:340469 26/96 (27%)
Faf2NP_477388.1 UBA_FAF2 12..49 CDD:270597
UAS_ETEA 163..280 CDD:239289 29/136 (21%)
PDCD7 267..>370 CDD:464979 36/109 (33%)
UBX_UBXN3B 373..461 CDD:340537 23/87 (26%)
Blue background indicates that the domain is not in the aligned region.

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