DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRT and Lar

DIOPT Version :9

Sequence 1:XP_024307588.1 Gene:PTPRT / 11122 HGNCID:9682 Length:1535 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1666 Identity:423/1666 - (25%)
Similarity:664/1666 - (39%) Gaps:483/1666 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    95 LKENDTHCID-------FHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTE------GW 146
            :..::.:.:|       ::.:.::|.:...||....:.|.....|.|..|::.:.|.      .|
  Fly   570 ISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSW 634

Human   147 VKAELAISTFWPHFYQVIF--------ESVSLKGHPGYIAVDEVR--------VLAHPC-----R 190
            :...:..|.....:|:|.|        |:.::..:...|.:||::        |||...     |
  Fly   635 LPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPR 699

Human   191 KAPHFLR----------------LQNVEVNVGQNATFQCIAGG---KWSQHDKLWLQQWNGRDTA 236
            ..|..||                |.:..::|......:....|   .:..|.:....:..|....
  Fly   700 SHPIILRTQEDVPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNE 764

Human   237 LMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEP-PTPIAPPELLAV 300
            .....||:...|:.|....|| :.|:.......:.||    ...|.::||.| ..|:.|...|  
  Fly   765 PFKFDVVDTLEFNVTGLQPDT-KYSIQVAALTRKGDG----DRSAAIVVKTPGGVPVRPTVSL-- 822

Human   301 GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKL-W---------------- 348
                        .|:...||:..|:|:.....|:.|..     .|:| |                
  Fly   823 ------------KIMEREPIVSIELEWERPAQTYGELR-----GYRLRWGVKDQALKEEMLSGPQ 870

Human   349 -------HLDPDVEYEIRVL-------------LTRPGEGGTGPPGPPLTTRTKCADPVHGPQNV 393
                   :|:..||||.||.             :.:..||..|.|...:|.|.:..|        
  Fly   871 MTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQTPD-------- 927

Human   394 EIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQY---------------------QYVFNQQQYEA 437
                    .|.:.|:|    .||.|...:..:|                     :.||...:...
  Fly   928 --------VLCVTWDP----PTREHRNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENT 980

Human   438 EEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKI 502
            |.:.:..: ||.:|..||                 |::|:|:||.|: |..|: |:|.....|:.
  Fly   981 EYIFRVRA-YTKQGAGPF-----------------SDKLIVETERDM-GRAPM-SLQAEATSEQT 1025

Human   503 YIQWKPPNETNGVITLYEINY-------------KAVGSLDPSADL------------------- 535
            ...|..|..:.|.:..|:|.|             |.|| |..||||                   
  Fly  1026 AEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVG-LTESADLVNLEKFAQYAVAIAARFKN 1089

Human   536 ----SSQRGKV-----------------------------------FKLRNETHHLFVG------ 555
                .|::..|                                   :|:..:...:||.      
  Fly  1090 GLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQ 1154

Human   556 ----------------------LYPGTTYSFTIKASTAK-GFGPPVTTRIATKISAPSMPEYDTD 597
                                  |.|.|||:..:.|..:. .:.||....:.|:::||.       
  Fly  1155 TQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQ------- 1212

Human   598 TPLNETD-------TTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSY--- 652
             |:.:.|       ..|.|:|..|.....|:|.|.|||..|         |......:|..:   
  Fly  1213 -PMVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPE---------DKSNLHKIPDQFLTD 1267

Human   653 -----RNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKAN 712
                 ||.....:..|.||:....::|.|  |.:|....|:.:.|..|...|.|.|:.:|:....
  Fly  1268 DLLPGRNKPERPNAPYIAAKFPQRSIPFT--FHLGSGDDYHNFTNRKLEREKRYRIFVRAVVDTP 1330

Human   713 GETKINCVRLATKAP------MGSAQVTPG------TPLCLLTTGASTQNSNTVEPEKQVDNTVK 765
            .:      .|.|.:|      :...:..||      .|........|. |.|..|||        
  Fly  1331 QK------HLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSV-NRNKDEPE-------- 1380

Human   766 MAGVIAGLLMFIIIL---LGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPT 827
            :..|:..|::...|:   |.|:..:||||...           :...|:...|   |:.:||   
  Fly  1381 ILWVVLPLMVSTFIVSTALIVLCVVKRRRQPC-----------KTPDQAAVTR---PLMAAD--- 1428

Human   828 TKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQ------- 885
              |.|.                          ||         ..|||:|.  |..||       
  Fly  1429 --LGAG--------------------------PT---------PSDPVDMR--RLNFQTPGMISH 1454

Human   886 PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISCRGRSPAK 950
            |.|.:::...||.::|......|.:|||::..||..:||.:..:.|::||||.|:          
  Fly  1455 PPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANV---------- 1509

Human   951 RADMRKTPQLDKEMSSVFPEAPLIQRRTLAATWDDHSRVRLLVLDGDPHSDYINANYIDGYHRPR 1015
                                           |..|||||:|..::|...||||||||.|||.:..
  Fly  1510 -------------------------------TAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHN 1543

Human  1016 HYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGNATLGRAASPGMVKCVRY 1080
            .|:|||||:|||..|||||.|:..:|:|||:|.|.|..|                    :||.:|
  Fly  1544 AYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTR--------------------IKCDQY 1588

Human  1081 WPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLG 1144
            ||. .||.||.|.||:.||:.||.|.||||.:.::|:::.||::...||:|||||||.:....|.
  Fly  1589 WPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQ 1653

Human  1145 FVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQT 1209
            |:|:.:.|.|||:||::||||||.|||||:|.||:||:..::|.::||:..|..|||||..:|||
  Fly  1654 FLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQT 1718

Human  1210 EEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRL---DPQTNSSQIKDEFQTLNIVTPRVRP 1271
            |:||:|:|||||||.:||.|.:|.   |:|:.::.:|   :|....|.::.||:.|:.|  ::..
  Fly  1719 EDQYIFIHDAILEAIICGVTEVPA---RNLHTHLQKLLITEPGETISGMEVEFKKLSNV--KMDS 1778

Human  1272 EDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPN 1335
            .......||.|..|||.:.:||.:....:|..:.| |.|:|:||:.:|.::..:|::..|.|:.:
  Fly  1779 SKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQD 1843

Human  1336 TVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFR 1398
            ...||||:::::|.:.||||.::..  .:.|.||||.:.|..|   |...|....:.::.....|
  Fly  1844 AAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRY---QYYVVDPIAEYNMPQYKLR 1905

Human  1399 ICNMARPQDG-YRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGG 1462
            ...:...:|| .|.|:..|:|.||. :..|.|....:..:.::.|.:||: |::|...|||..|.
  Fly  1906 EFKVTDARDGSSRTVRQFQFIDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPITVHCSAGV 1968

Human  1463 GRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVET 1503
            ||||.|..:..|.|.:|.:.::|||..|:.||:.:..||:|
  Fly  1969 GRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQT 2009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRTXP_024307588.1 MAM 29..189 CDD:214533 21/122 (17%)
fn3 294..360 CDD:306538 17/89 (19%)
FN3 390..480 CDD:238020 18/110 (16%)
fn3 502..577 CDD:306538 25/174 (14%)
PTPc 985..1222 CDD:238006 119/237 (50%)
PTPc 1284..1504 CDD:238006 71/224 (32%)
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020
FN3 520..610 CDD:238020 5/39 (13%)
FN3 616..707 CDD:238020 18/90 (20%)
FN3 712..810 CDD:238020 16/102 (16%)
FN3 832..907 CDD:238020 14/79 (18%)
FN3 914..1005 CDD:238020 22/128 (17%)
FN3 1012..1101 CDD:238020 19/90 (21%)
fn3 1106..1198 CDD:278470 9/91 (10%)
PTPc 1476..1731 CDD:214550 134/315 (43%)
PTPc 1503..1731 CDD:238006 125/288 (43%)
PTPc 1763..2022 CDD:214550 78/254 (31%)
PTPc 1791..2022 CDD:238006 71/224 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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