Protein Alignment PTPRT and Ptp36E

DIOPT Version :9

• Sequence 1: XP_024307588.1
• Gene: PTPRT / 11122
• HGNCID: 9682
• Length: 1535
• Species: Homo sapiens
• Sequence 2: NP_001286033.1
• Gene: Ptp36E / 35091
• FlyBaseID: FBgn0267486
• Length: 682
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 188/560 - (33%)
• Similarity: 296/560 - (52%)
• Gaps: 52/560 - (9%)

Human   985 DHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNL 1049
            |::||.|..:.|...|||:||:|:|...:|..||.||||::|||:.:|||:||||.::|||:|..
  Fly   138 DYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKT 202

Human  1050 VEVGRHPAEHTVGNATLGRAASPGMVKCVRYWPDDTEV---YGDIKVTLIETEPLAEYVIRTFTV 1111
            .:..:                    |.|.:|||.:.||   ||||.:.::..|.||.:.||||.:
  Fly   203 FDFAK--------------------VMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRL 247

Human  1112 QKKG-YHEIRELRL---FHFTSWPDHGVPCYATGLLGFVRQVKFL-------NPPEAGPIVVHCS 1165
            .|.. ..|:.:.||   ||:|.|..|..| ::..||.|.|:|:.:       .....|||:||||
  Fly   248 YKMNEKQEVTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIIKDEDDMRGPILVHCS 311

Human  1166 AGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTA 1230
            .|.||:|.:::||..|::||.|...::|..:::||..|..||:..|||.|::|.:.|..:||.|.
  Fly   312 DGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTW 376

Human  1231 IPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLD 1295
            .||.|........:|.:..|..::.:.|:..:...|||....||:.|....|.:|||.:..:|.|
  Fly   377 FPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPD 441

Human  1296 RCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD 1359
            ...|:|.|..|.: ::|||:..:|.:.:|..::||:.|:.:|:.:||.||:|..||:||:|.:..
  Fly   442 NFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPP 506

Human  1360 T-AQFCMQYWPEKTS-GCYGPI-QVEFVSADIDEDIIHRIFRICN--------MARPQDGYRIVQ 1413
            : :|....:||.|:. ..|||: .|.:|.:....:|....|:|..        ||..:...|.||
  Fly   507 SQSQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQ 571

Human  1414 HLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMI 1478
            ..|...||.....|.|..||:.::..:|.|:.:.|  .|...|...:|..|:|.:||..:..|.:
  Fly   572 LFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVD--YGPVCVVSPDGRSRAGVYCAANACIEQV 634

Human  1479 QQQNIIDVFHIVKTLRNNKSNMVETL---RLCKGTLLHTV 1515
            .|...:|||..|||:|.::..:||.:   :.|...:||.|
  Fly   635 IQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRT	XP_024307588.1	MAM	29..189	CDD:214533
		fn3	294..360	CDD:306538
		FN3	390..480	CDD:238020
		fn3	502..577	CDD:306538
		PTPc	985..1222	CDD:238006	94/250 (38%)
		PTPc	1284..1504	CDD:238006	73/231 (32%)
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	94/250 (38%)
		Y_phosphatase	428..671	CDD:395053	75/244 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000829
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.770