DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRT and ptprt

DIOPT Version :9

Sequence 1:	XP_024307588.1	Gene:	PTPRT / 11122	HGNCID:	9682	Length:	1535	Species:	Homo sapiens
Sequence 2:	XP_004918595.1	Gene:	ptprt / 100496210	XenbaseID:	XB-GENE-5717729	Length:	1486	Species:	Xenopus tropicalis

Alignment Length:	1539	Identity:	1214/1539 - (78%)
Similarity:	1322/1539 - (85%)	Gaps:	112/1539 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    11 LLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFM 75
            ||:.|||  .|.|..:..||||:|:|||::||||||||||||||||:||||:|.||.::||||||
Frog     6 LLIFLQL--FPAAGGEVFAGGCTFEEHYNSCGYSVALGTNGFTWEQVNTWERPPLDPSIPTGSFM 68

Human    76 MVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSG 140
            :|||||.|||||||||||.||||||||||||||.|.  |:|||:|||||||||||||||||||||
Frog    69 VVNSSGFASGQKAHLLLPVLKENDTHCIDFHYYMSG--RTSPGSLNVYVKVNGGPQGNPVWNVSG 131

Human   141 VVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNV 205
            |||||||.||||||||||:|||:|||:||:|.|.||||||||||||||||.||||||||||||||
Frog   132 VVTEGWVHAELAISTFWPNFYQIIFEAVSVKDHSGYIAVDEVRVLAHPCRNAPHFLRLQNVEVNV 196

Human   206 GQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIR 270
            |||||||||||||||||||||||||||||||||||||||||||||||||.||:|||:||||||:|
Frog   197 GQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVGDTSQRSISKYRCVLR 261

Human   271 SDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWA 335
            |.|||||||||||.||||||||||||||||||||||||||||||||||||:|||||||||:|:||
Frog   262 SSGGSGVSNYAELSVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIVLKEVEYRTTSGSWA 326

Human   336 ETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRA 400
            |||::|.|.||||||||||||||||||||||||||||||||||||||||||||||||||:|||||
Frog   327 ETHVMDGPTYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVELVDIRA 391

Human   401 RQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLS 465
            ||||||||||||:||||||||||:.|.:...:.:.||||::.||||||||||||...:.|||.|.
Frog   392 RQLTLQWEPFGYSVTRCHSYNLTLHYSFQLGEDRVEAEELVLTSSHYTLRGLRPHTAVYLRLALC 456

Human   466 NPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLD 530
            |||||.||.|:||.|||||||.:|||||||||||||||:|||.||||||||::||:.||||||||
Frog   457 NPEGRKESGEIVVHTEEDVPGPIPLESIQGGPFEEKIYLQWKAPNETNGVISMYEVTYKAVGSLD 521

Human   531 PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYD 595
            ||||||:|:|::|||||||||||||||||:||||||:|||:||||||||.||||||:|||:.:.:
Frog   522 PSADLSNQKGRIFKLRNETHHLFVGLYPGSTYSFTIRASTSKGFGPPVTARIATKIAAPSLTDSE 586

Human   596 TDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS 660
            .:.|||||::||||.||||||||||||.|||||||||.|:|.||||...||.|||.|||||||:|
Frog   587 AEAPLNETESTITVWLKPAQSRGAPVSAYQLVVKEERAQRSGRAADGSGCFPVPVGYRNASSLES 651

Human   661 LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATK 725
            .|||||||||:.|.||||||||||:||||||||||||:|||||||||||.|||||||.|||||:|
Frog   652 SHYFAAELKPSQLAVTQPFTVGDNRTYNGYWNPPLSPVKSYSIYFQALSTANGETKIGCVRLASK 716

Human   726 -APMGSAQVT---PGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLT 786
             |..|...:|   |..|:    |||||.|||||||||..|:||:.||||||:|||||||||.|:|
Frog   717 AATAGLLPITRHPPSQPV----TGASTLNSNTVEPEKPADSTVQTAGVIAGMLMFIIILLGAMMT 777

Human   787 IKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFT- 850
            ||||||.|||||||||||||||||||:|||||.||| ||.::|||::||::.| ||.||||||:
Frog   778 IKRRRNVYSYSYYLKLAKKQKETQSGSQREMGLVAS-DKSSSKLSSTRNEDTF-SSCQDVNGFSS 840

Human   851 ------------------------------------DGSRGELSQPTLTIQTHPYRTCDPVEMSY 879
                                                |.|..:::||||||||||||||:|:||:|
Frog   841 SSPCSFSVQSKNIQGKSLLSSCYSVSSDTVPSLALLDNSHVDMNQPTLTIQTHPYRTCEPLEMAY 905

Human   880 PRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISCR 944
            ||.|.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
Frog   906 PRGQLQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISY- 969

Human   945 GRSPAKRADMRKTPQLDKEMSSVFPEAPLIQRRTLAATWDDHSRVRLLVLDGDPHSDYINANYID 1009
                                                    |||||||..::||||||||||||:|
Frog   970 ----------------------------------------DHSRVRLQQIEGDPHSDYINANYVD 994

Human  1010 GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHPAEHTVGNATLGRAASPGM 1074
            ||||||:||||||||||||||||||||||||.|:|||||||||||
Frog   995 GYHRPRYYIATQGPMQETVKDFWRMIWQENSVSVVMVTNLVEVGR-------------------- 1039

Human  1075 VKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYA 1139
            |||||||||:|||||||||:|||||||||||||||||||||.|:|||:|.|||||||||||||||
Frog  1040 VKCVRYWPDETEVYGDIKVSLIETEPLAEYVIRTFTVQKKGSHDIREIRQFHFTSWPDHGVPCYA 1104

Human  1140 TGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRV 1204
            ||||||:|||||||||:||||.||||||||||||.||||.|||||||||||||||||||||||||
Frog  1105 TGLLGFIRQVKFLNPPDAGPITVHCSAGAGRTGCLIAIDIMLDMAENEGVVDIFNCVRELRAQRV 1169

Human  1205 NLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRV 1269
            |:|||||||||||||||||||||||||||.||||:||||||:|||||.||||||||||||||||.
Frog  1170 NMVQTEEQYVFVHDAILEACLCGNTAIPVSEFRSVYYNISRMDPQTNCSQIKDEFQTLNIVTPRA 1234

Human  1270 RPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLP 1334
            ||||||||||||||||||::||||||||||||||:|||:||||||.||||||:||||:|||||||
Frog  1235 RPEDCSIGLLPRNHDKNRALDVLPLDRCLPFLISMDGETSNYINATLMDSHKKPAAFLVTQHPLP 1299

Human  1335 NTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRI 1399
            |||.|||||||||||||:|||||||:.|.|:||||||||.||||:||||||||||||||.|||||
Frog  1300 NTVPDFWRLVFDYNCSSIVMLNEMDSTQLCLQYWPEKTSCCYGPVQVEFVSADIDEDIISRIFRI 1364

Human  1400 CNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGR 1464
            |||||||||||||||||||||||||||||||||:||||:|||||||:||||||||||||||||||
Frog  1365 CNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSILKVVQRLEKWQEKYDGREGRTVVHCLNGGGR 1429

Human  1465 SGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLRLCK 1508
            ||||||||||||||||||||||||.||||||||:||||||...|
Frog  1430 SGTFCAICSVCEMIQQQNIIDVFHTVKTLRNNKANMVETLEQYK 1473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRT	XP_024307588.1	MAM	29..189	CDD:214533	133/159 (84%)
		fn3	294..360	CDD:306538	58/65 (89%)
		FN3	390..480	CDD:238020	63/89 (71%)
		fn3	502..577	CDD:306538	61/74 (82%)
		PTPc	985..1222	CDD:238006	196/236 (83%)
		PTPc	1284..1504	CDD:238006	198/219 (90%)
ptprt	XP_004918595.1	MAM	21..180	CDD:214533	133/160 (83%)
		MAM	25..180	CDD:99706	130/156 (83%)
		Ig	187..272	CDD:299845	79/84 (94%)
		FN3	280..351	CDD:214495	63/70 (90%)
		FN3	381..471	CDD:238020	63/89 (71%)
		fn3	493..568	CDD:278470	61/74 (82%)
		PTPc	933..1187	CDD:214550	232/314 (74%)
		PTPc	960..1187	CDD:238006	205/287 (71%)
		PTPc	1219..1481	CDD:214550	230/255 (90%)
		PTPc	1249..1481	CDD:238006	201/225 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	519	1.000	Domainoid score	I3442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56924
Inparanoid	1	1.050	2539	1.000	Inparanoid score	I382
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44942
OrthoDB	1	1.010	-	-		D14603at32523
OrthoFinder	1	1.000	-	-		FOG0000829
OrthoInspector	1	1.000	-	-		oto158249
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7598
SonicParanoid	1	1.000	-	-		X7836
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.110