DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN2A1 and syg-2

DIOPT Version :9

Sequence 1:	NP_008980.1	Gene:	BTN2A1 / 11120	HGNCID:	1136	Length:	527	Species:	Homo sapiens
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	326	Identity:	69/326 - (21%)
Similarity:	132/326 - (40%)	Gaps:	91/326 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    16 LLLLLSLCALVSAQFIVVGPTDPILATV-GENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYK 79
            :||.|.....:|:||.:..|::  |:|: ||:.|.||  |.||              ||...||.
Worm     6 ILLWLFGSIHISSQFFLESPSN--LSTIAGESITFRC--SAEK--------------SPEPIVYS 52

Human    80 GGRERT--------EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYF---QEGRSY 133
            ..:..|        |..:..::||.:::.::..  .:.|.|.::...::|.|.|..   :||...
Worm    53 QWKSNTGSLLGYHQEGILPGHQGRFSYIKQNAE--ELHLKITHVNLDDDGEYECQMLHPEEGPIR 115

Human   134 DEAILHLVV-------AGLGSKPLISMRGHEDGGIRLECISRGWYPKPLTVWRDPYGGVAPALKE 191
            .::.|:::|       :......:|:::  |:..:.:.|:.....|:|..:|......::..:|:
Worm   116 AKSFLNIIVPPQLVYFSNYQPNSIIAVK--ENTPLNITCVVPNVKPEPEVLWYMDGKVMSRDVKQ 178

Human   192 VSMPDADGLFMVTTAVIIRDKSVRN-----MSC-----------SINNTLLGQKKESVIFIPESF 240
            .|.|..:..|.|.|::::  :|.||     ::|           :.|.||      .|:|.|..
Worm   179 ASTPHLNKTFTVYTSLVV--QSDRNDHGKVITCEAFQKETDIRITTNTTL------DVLFPPSD- 234

Human   241 MPSV----SPCAVALPIIVVILMIPIAVC----------IYWINKLQKEKKILSGEKEFERETRE 291
             |:|    :|.|:.....|.|      .|          ::|.:    |.|.|......:..::|
Worm   235 -PTVEILRNPSALRSGDNVTI------ACSVTGGNPPPDVFWYH----ENKRLQSHSTLDTRSKE 288

Human   292 I 292
            |
Worm   289 I 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN2A1	NP_008980.1	IG_like	38..142	CDD:214653	26/115 (23%)
		Ig_MOG_like	44..143	CDD:143190	25/116 (22%)
		SPRY_PRY_BTN1_2	327..500	CDD:293991
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653	23/99 (23%)
		Ig	33..122	CDD:299845	24/106 (23%)
		Ig	147..228	CDD:299845	17/88 (19%)
		IGc2	248..313	CDD:197706	9/52 (17%)
		Ig	450..537	CDD:299845
		Ig	559..632	CDD:299845
		I-set	657..738	CDD:254352
		Ig	665..738	CDD:299845
		IG_like	748..828	CDD:214653
		IGc2	756..817	CDD:197706
		Ig	845..922	CDD:299845
		FN3	934..1023	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910