DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXN3 and foxo

DIOPT Version :10

Sequence 1:NP_001078940.1 Gene:FOXN3 / 1112 HGNCID:1928 Length:490 Species:Homo sapiens
Sequence 2:NP_650330.3 Gene:foxo / 41709 FlyBaseID:FBgn0038197 Length:622 Species:Drosophila melanogaster


Alignment Length:437 Identity:102/437 - (23%)
Similarity:153/437 - (35%) Gaps:141/437 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    84 VSPVQDLD----DDTPPSPAHSDMPYDARQNPNCKPP----------YSFSCLIFMAIEDSPTKR 134
            |.|..:||    .:...:|..|.   .|.||.|....          .|::.||..||..:..||
  Fly    54 VEPTDELDSTKASNQQLAPGDSQ---QAIQNANAAKKNSSRRNAWGNLSYADLITHAIGSATDKR 115

Human   135 LPVKDIYNWILEHFPYF-----ANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPE 194
            |.:..||.|::::.|||     :|:..|||||:||||||:..|.:|..|   ..||.|.|.::||
  Fly   116 LTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNE---GTGKSSWWMLNPE 177

Human   195 ------------------YRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTS-GPPIWPGSTFF 240
                              |.:...:|.|:........|.......|....|.| |...:|.|...
  Fly   178 AKPGKSVRRRAASMETSRYEKRRGRAKKRVEALRQAGVVGLNDATPSPSSSVSEGLDHFPESPLH 242

Human   241 KRNGALLQDPDI------DAASAMMLLNTPPEIQA-----GFP-----PGVIQNGARVLSRGLFP 289
            ...|..| .||.      :|:|...|  :|...|.     |||     ..:.|..|:.|..    
  Fly   243 SGGGFQL-SPDFRQRASSNASSCGRL--SPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEE---- 300

Human   290 GVRPLPITPIGVTAAMRNGITSCRMRTE---------SEP-----------------SCGSPVVS 328
                       :|..|.:.:|.|..:.:         |:|                 ...||...
  Fly   301 -----------LTGTMADELTLCNQQQQGFSAASGLPSQPPPPPYQPPQHQQAQQQQQQQSPYAL 354

Human   329 GDPKEDHNYSSAKSS-------------NAR-STSPTSDSISSSSSSADDHYEFATKGSQEGSEG 379
            ..|...:|....:|.             ||| ..||  :|::::.|.|           ...||.
  Fly   355 NGPASGYNTLQPQSQCLLHRSLNCSCMHNARDGLSP--NSVTTTMSPA-----------YPNSEP 406

Human   380 SEGSFRSH-----ESPSDT-----EEDDRKHSQKEPKDSLGDSGYAS 416
            |..|..::     :.|:||     ::..::..|::...||.|:..||
  Fly   407 SSDSLNTYSNVVLDGPADTAALMVQQQQQQQQQQQLSASLEDNNCAS 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXN3NP_001078940.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 86..108 5/25 (20%)
FH_FOXN3 114..203 CDD:410833 36/121 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 315..458 28/152 (18%)
foxoNP_650330.3 FH_FOXO 96..175 CDD:410806 33/81 (41%)
Blue background indicates that the domain is not in the aligned region.

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