DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN3A1 and RGD1624210

DIOPT Version :9

Sequence 1:	NP_008979.3	Gene:	BTN3A1 / 11119	HGNCID:	1138	Length:	513	Species:	Homo sapiens
Sequence 2:	XP_038954996.1	Gene:	RGD1624210 / 686977	RGDID:	1624210	Length:	548	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	187/509 - (36%)
Similarity:	292/509 - (57%)	Gaps:	29/509 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    10 LLLNFRVCLLLLQL-LMPHSA------QFSVLGPSGPILAMVGEDADLPCHLFPTMSAETM-ELK 66
            ::..||||.:...: |.|.:|      .|.|.|||.||:|.:|.:|.|||.:||.||.|.| ||:
  Rat    13 MIFFFRVCSVHCPVSLQPLTATSVSTEDFLVFGPSDPIVATLGGEAILPCSVFPVMSVENMEELR 77

Human    67 WVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDG 131
            |..:...:.|.||.|.:|.::.|...|..|||:::|....||||:||.||..||||.|:|:|:.|
  Rat    78 WFRTRFSEAVFVYRDQEEQKEGQLPGYSQRTSLVKDQFHEGKAAVRIQNVQESDSGIYVCHFKQG 142

Human   132 DFYEKALVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVA 196
            .|:|:|::||||||:||...|.:||.::||:.:.|.::||||:||:.|.:::||::|.....:..
  Rat   143 HFHEEAILELKVAAMGSVPEVYIKGPEEGGVCVVCMTSGWYPEPQVHWRDSRGEDLPASSETLHE 207

Human   197 DGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLL 261
            |..||::...|:::|.||...|:|:..:.:||.||..::.|.:|||..|..|.|.::..|.::.:
  Rat   208 DAEGLFSTETSLVLRDSSVRNVTCSTFNPILGQEKAMAMVIPEPFFPQASPWKADISEILKMMQV 272

Human   262 LLGGAGYFLWQ------QQEEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYA 320
            ||......|.:      :.:.|.:.|:.:|.|.::      |.:....|...|.|||..|...|.
  Rat   273 LLLLTSCLLMRAHSARLRLQWKWSHFQLEKDESQM------TKEDALRTASALREELDRRKAAYN 331

Human   321 SRGERHSAYNEWKKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVL 385
            ....:...|.:|:|..|:.....|||.:|:|.|::|:|:..|.|       .|.....:..:.||
  Rat   332 RAWRKAHLYADWRKEHFQTWTFTLDPGSAHPTLVISQDRMRVTR-------KDTIVCLDGLFSVL 389

Human   386 GCESFISGRHYWEVEV--GDRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPR 448
            |.:...|||:||||::  |:..:|.:|||.:.|:|||:...:||.||||:|.:....:..:...|
  Rat   390 GTKGISSGRYYWEVKLANGEGSKWILGVCREGVERKGFYFESPEKGFWTVGQSSCGYFAYVDRGR 454

Human   449 TNLKLPKPPKKVGVFLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRILT 502
            .:|.:.:.|:.||||:||:.|||||||..|.|||.:|...|.|..|.|.||:::
  Rat   455 ASLSIRQAPQSVGVFVDYDEGDISFYNMSDMSHIFSFHKASLSGTLLPYFRLMS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A1	NP_008979.3	IG_like	37..143	CDD:214653	50/106 (47%)
		Ig_MOG_like	45..144	CDD:143190	47/99 (47%)
		SPRY_PRY_BTN3	337..512	CDD:293992	65/168 (39%)
RGD1624210	XP_038954996.1	IgV_MOG_like	41..155	CDD:409378	55/113 (49%)
		Ig strand B	58..62	CDD:409378	2/3 (67%)
		Ig strand C	74..79	CDD:409378	2/4 (50%)
		Ig strand E	120..124	CDD:409378	2/3 (67%)
		Ig strand F	134..139	CDD:409378	2/4 (50%)
		Ig strand G	147..150	CDD:409378	1/2 (50%)
		Ig	158..242	CDD:416386	29/83 (35%)
		SPRY_PRY_C-I_1	353..506	CDD:293968	63/159 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I34658
eggNOG	1	0.900	-	-		E1_28KB3
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39342
OrthoDB	1	1.010	-	-		D186278at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X198
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830