DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN3A1 and Btnl4

DIOPT Version :9

Sequence 1:	NP_008979.3	Gene:	BTN3A1 / 11119	HGNCID:	1138	Length:	513	Species:	Homo sapiens
Sequence 2:	NP_109671.1	Gene:	Btnl4 / 632126	MGIID:	1932036	Length:	586	Species:	Mus musculus

Alignment Length:	502	Identity:	191/502 - (38%)
Similarity:	280/502 - (55%)	Gaps:	26/502 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    12 LNFRV-CLLLLQLLMP--HSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETM-ELKWVSSSL 72
            |.|.| ||.:|..|:.  .:.:|.|.|||.||:|..|.:|.|||.:||.|:.|.| ||:|..|..
Mouse     9 LLFHVPCLFVLTQLLSWVTTQEFRVFGPSDPIVAAPGGEAILPCSVFPAMNVENMEELRWFRSRF 73

Human    73 RQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKA 137
            .:.|..|.|.:|.::.|...|..||.:::|....|.||:||.||.|||||.|:|:||.|.||::|
Mouse    74 SEAVLFYRDQEEQKEGQMPGYSQRTLLVKDQFHQGTAAVRILNVQASDSGIYICHFQQGVFYDEA 138

Human   138 LVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPV-VADGVGL 201
            ::||||||:||...|.:||.:|||:.:.|.::||||:||:.|.:::|||:....:.. ..|..||
Mouse   139 ILELKVAAMGSVPEVHIKGPEDGGVCVVCMTSGWYPEPQVHWKDSRGENLTAFSSETHTKDAEGL 203

Human   202 YAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLLLLGGA 266
            ::....:::|.||...|:|:|.:.:||.||..::.|.:|||..|..|..|...||.::.||:.|.
Mouse   204 FSTETLLVVRDSSVRNVTCSIFNPILGQEKATAMFIPEPFFPQASPWKPAFLVTLTMMGLLVLGT 268

Human   267 GYFLWQQQ------EEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYASRGER 325
            .|.|.::.      :::...|:::|.|      :..|......|...|:.|...|...|.:..::
Mouse   269 SYLLRREHSARLKVQQETVNFQREKDE------SLKTRDDALRTAGALMVERDRRKAAYRAAWKK 327

Human   326 HSAYNEWKKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVLGCESF 390
            ...|.:|:|..|:.....|||.:|:|||.:|.|:.||.|......|.|       .:||||....
Mouse   328 AQLYADWRKEHFEAWTFTLDPASAHPILAISPDRLSVSRKDSTLCLDD-------LFCVLGIRGI 385

Human   391 ISGRHYWEVEV--GDRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPRTNLKL 453
            .||||||||::  ||..:|.:|||.:.|.|||.....|..||||:|.:.......:......|.|
Mouse   386 SSGRHYWEVKLRNGDSSKWTLGVCREGVDRKGCFSECPHKGFWTVGRSSSGYLAYIDTGTALLSL 450

Human   454 PKPPKKVGVFLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRI 500
            .:.|:.||||:||..|||||||..|.|.:.:|.:.|||..|:|.||:
Mouse   451 RQAPQSVGVFVDYTEGDISFYNMSDMSPMFSFHEASFSGTLFPYFRL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A1	NP_008979.3	IG_like	37..143	CDD:214653	49/106 (46%)
		Ig_MOG_like	45..144	CDD:143190	46/99 (46%)
		SPRY_PRY_BTN3	337..512	CDD:293992	69/166 (42%)
Btnl4	NP_109671.1	Ig	45..145	CDD:386229	46/99 (46%)
		Ig	<167..233	CDD:386229	22/65 (34%)
		SPRY_PRY_C-I_1	344..497	CDD:293968	67/159 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KB3
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39342
OrthoDB	1	1.010	-	-		D186278at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X198
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830