DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN3A1 and Btnl6

DIOPT Version :9

Sequence 1:	NP_008979.3	Gene:	BTN3A1 / 11119	HGNCID:	1138	Length:	513	Species:	Homo sapiens
Sequence 2:	NP_109672.1	Gene:	Btnl6 / 624681	MGIID:	1932038	Length:	539	Species:	Mus musculus

Alignment Length:	504	Identity:	185/504 - (36%)
Similarity:	275/504 - (54%)	Gaps:	31/504 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    10 LLLNFRVCLLLLQLL-MPHSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETM-ELKWVSSSL 72
            ||.:.....:|:||| ...:.:|.|.|||.||:|..|.:|.|||.:.|.|:.|.| ||:|..|..
Mouse     9 LLFHVSCLFVLIQLLSWVTTKEFQVFGPSDPIVAAPGGEAILPCSVIPAMNVENMEELRWFRSRF 73

Human    73 RQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKA 137
            ...|.||.|.:|.:..|...|..|||::::....|.||:||.||.|.|||.|:|:|:.|.|||:|
Mouse    74 SAAVLVYRDQEEQKREQLPEYSQRTSLVKEQFHQGTAAVRILNVQAPDSGIYICHFKQGVFYEEA 138

Human   138 LVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLY 202
            ::||||||:||...|.:||.:|||:.:.|.::||||:||:.|.:::||.:.........|..||:
Mouse   139 ILELKVAAMGSVPEVYIKGPEDGGVCVVCITSGWYPEPQVHWKDSRGEKLTASLEIHSEDAQGLF 203

Human   203 AVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLLLLGGAG 267
            ....|:::|.||...|:|:..:.:||.||..::.:.:|||.....|..|...||.::.||:.|..
Mouse   204 RTETSLVVRDSSVRNVTCSTFNPILGQEKAMAMFLPEPFFPKVSPWKPAFFVTLTMMGLLVLGTS 268

Human   268 YFLWQQQEEKKTQFRKKKRE----QELR---EMAWSTMKQEQSTRV--KLLEELRWRSIQYASRG 323
            |.           ||:::..    |||.   :.......:|.:.|.  .|:.||..|...|.:..
Mouse   269 YL-----------FRRERSARLIVQELTGNLQRVEDNKAEEDTVRTIDALMVELAQRKAAYRAAW 322

Human   324 ERHSAYNEWKKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVLGCE 388
            .:...|.:|:|..|:.....|||.:|:..|.:|:|:.:|.|....:.|.|..       ||||..
Mouse   323 RKAQLYADWRKEQFQAWTFTLDPASAHTNLAISQDRLTVTRKDFTRCLEDLS-------CVLGIR 380

Human   389 SFISGRHYWEVEVG--DRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPRTNL 451
            ...|||:||||::.  :..:|.:|||.:.|.||.:...||..||||:|.:....:..:...||:|
Mouse   381 GISSGRYYWEVKLTNIEGSKWILGVCREGVVRKNFYFETPRKGFWTVGQSSKGHWAYIDSGRTSL 445

Human   452 KLPKPPKKVGVFLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRI 500
            .:.:.||.||||:||..|||||||..|.||:.:|...|||..|:|.||:
Mouse   446 SVRQAPKSVGVFVDYTEGDISFYNMSDMSHMFSFPKASFSGTLFPYFRL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A1	NP_008979.3	IG_like	37..143	CDD:214653	48/106 (45%)
		Ig_MOG_like	45..144	CDD:143190	45/99 (45%)
		SPRY_PRY_BTN3	337..512	CDD:293992	66/166 (40%)
Btnl6	NP_109672.1	Ig	45..145	CDD:386229	45/99 (45%)
		Ig	150..232	CDD:386229	27/81 (33%)
		SPRY_PRY_C-I_1	341..503	CDD:293968	65/161 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KB3
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39342
OrthoDB	1	1.010	-	-		D175892at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X198
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830