DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTN3A1 and DIP-eta

DIOPT Version :9

Sequence 1:	NP_008979.3	Gene:	BTN3A1 / 11119	HGNCID:	1138	Length:	513	Species:	Homo sapiens
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	290	Identity:	59/290 - (20%)
Similarity:	109/290 - (37%)	Gaps:	68/290 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     2 KMASFLAFLLLNFRVCLLLLQLLMPHSAQFS---VLGP--SGPILAM---VGEDADLPC---HLF 55
            |....|:.:||    .:|:.|...|...:..   ::.|  |.||:.|   ||.||.|.|   .|.
  Fly    10 KQTCALSVILL----LILMSQQCYPQRVEVPAEVIVDPKFSSPIVNMTAPVGRDAFLTCVVQDLG 70

Human    56 PTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKA---ALRIHNVT 117
            |      .::.|:....:.::.:  ....:...|           |.||...:.   .:||.::.
  Fly    71 P------YKVAWLRVDTQTILTI--QNHVITKNQ-----------RIGIANSEHKTWTMRIKDIK 116

Human   118 ASDSGKYLCYFQDGDFYEKALVELKVAA----LGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQ 178
            .||.|.|:|.. :.|..:..:..|.|..    |......|:...:...:.|:|.:|| .|:|.|.
  Fly   117 ESDKGWYMCQI-NTDPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATG-SPEPTIT 179

Human   179 WSNNK--------GENIPTVEAP------VVADGVGLYAVAASVIMRGSSGEGVS--------CT 221
            |....        ||.:.::|..      |....:|.|...||..:..|..:.::        .|
  Fly   180 WRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPPMIT 244

Human   222 IRSSLLGLEKTASISI---ADPFFRSAQRW 248
            :::.|:|..:...:::   ::.:.:|...|
  Fly   245 VQNQLIGAVEGKGVTLDCESEAYPKSINYW 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A1	NP_008979.3	IG_like	37..143	CDD:214653	26/114 (23%)
		Ig_MOG_like	45..144	CDD:143190	21/104 (20%)
		SPRY_PRY_BTN3	337..512	CDD:293992
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	23/109 (21%)
		IG_like	51..137	CDD:214653	22/105 (21%)
		IG_like	153..237	CDD:214653	18/84 (21%)
		Ig	161..224	CDD:299845	16/63 (25%)
		IG_like	252..335	CDD:214653	2/23 (9%)
		Ig	258..333	CDD:143165	2/17 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910