DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BTN3A1 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_008979.3	Gene:	BTN3A1 / 11119	HGNCID:	1138	Length:	513	Species:	Homo sapiens
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	245	Identity:	54/245 - (22%)
Similarity:	90/245 - (36%)	Gaps:	49/245 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    18 LLLLQLL-----MPHSAQFSVLGPSGP--------ILAMVGEDADLPC--------HLFPTMSAE 61
            ||||.||     :..|.:.|.:|...|        :....|.||...|        .:....|:.
  Fly    72 LLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSA 136

Human    62 TMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLC 126
            ..::.|:.:..:.::.::.......||.|..:....:          ..|.|..|...|:|||:|
  Fly   137 PAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNT----------WTLNIRGVKMEDAGKYMC 191

Human   127 YFQ-DGDFYEKALVELKVA--ALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIP 188
            ... |....:.|.:|:.:.  .:..:...|:...:.|...|.||:.| :|:|:|.|....|..|
  Fly   192 QVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARG-HPKPKITWRREDGREI- 254

Human   189 TVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIA 238
                 :..:|......|.||       ||...|: |.:...|..|.:.||
  Fly   255 -----IARNGSHQKTKAQSV-------EGEMLTL-SKITRSEMGAYMCIA 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A1	NP_008979.3	IG_like	37..143	CDD:214653	21/122 (17%)
		Ig_MOG_like	45..144	CDD:143190	20/107 (19%)
		SPRY_PRY_BTN3	337..512	CDD:293992
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	21/120 (18%)
		ig	102..195	CDD:278476	17/102 (17%)
		IG_like	219..307	CDD:214653	24/88 (27%)
		Ig	221..307	CDD:299845	24/86 (28%)
		Ig	311..404	CDD:299845
		IG_like	327..405	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910