DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN3A1 and Btn1a1

DIOPT Version :9

Sequence 1:	NP_008979.3	Gene:	BTN3A1 / 11119	HGNCID:	1138	Length:	513	Species:	Homo sapiens
Sequence 2:	NP_038511.1	Gene:	Btn1a1 / 12231	MGIID:	103118	Length:	524	Species:	Mus musculus

Alignment Length:	504	Identity:	216/504 - (42%)
Similarity:	292/504 - (57%)	Gaps:	48/504 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    16 VCLLLLQLL----MPHSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVV 76
            ||||.|.:|    :..:|.|.|..|..|:||:||.||:|.|...|..|:|.|||.|...:....|
Mouse    11 VCLLTLTVLQLPTLDSAAPFDVTAPQEPVLALVGSDAELTCGFSPNASSEYMELLWFRQTRSTAV 75

Human    77 NVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVEL 141
            .:|.||:|.|.:|...||||.::...|:..|:|.|.|.:|..||.|:|.|.|:|.|.:|:|.|.|
Mouse    76 LLYRDGQEQEGQQMTEYRGRATLATAGLLDGRATLLIRDVRVSDQGEYRCLFKDNDDFEEAAVYL 140

Human   142 KVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLYAVAA 206
            ||||:|||..:.:...::|.:.|||.|:||||:||:||.....|.:|:.......:..||:.||.
Mouse   141 KVAAVGSDPQISMTVQENGEMELECTSSGWYPEPQVQWRTGNREMLPSTSESKKHNEEGLFTVAV 205

Human   207 SVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAGTLPVLLLLLG----GAG 267
            |:::|.||.:.:||.|::.|||..|...||:..||......||.|:|    ::||.||    |:.
Mouse   206 SMMIRDSSIKNMSCCIQNILLGQGKEVEISLPAPFVPRLTPWIVAVA----IILLALGFLTIGSI 266

Human   268 YFLWQQQEEKKTQFRKKKREQELREMAWSTMKQEQSTRVKLLEELRWRSIQYASRGERHSAYNEW 332
            :|.|:..:|:.                 |..|:|..::.:||||||                  .
Mouse   267 FFTWKLYKERS-----------------SLRKKEFGSKERLLEELR------------------C 296

Human   333 KKALFKPADVILDPKTANPILLVSEDQRSVQRAKEPQDLPDNPERFNWHYCVLGCESFISGRHYW 397
            ||.:....||.|||.||:|.|.:.||.:||:.....|.|||.||||:...||||.|:|.||||||
Mouse   297 KKTVLHEVDVTLDPDTAHPHLFLYEDSKSVRLEDSRQILPDRPERFDSWPCVLGRETFTSGRHYW 361

Human   398 EVEVGDRKEWHIGVCSKNVQRKGWVKMTPENGFWTMGLTDGNKYRTLTEPRTNLKLPKPPKKVGV 462
            |||||||.:|.||||.:||.:||:..|||:||||.:.|. ||.|..||..||:|:|..||::|||
Mouse   362 EVEVGDRTDWAIGVCRENVVKKGFDPMTPDNGFWAVELY-GNGYWALTPLRTSLRLAGPPRRVGV 425

Human   463 FLDYETGDISFYNAVDGSHIHTFLDVSFSEALYPVFRILTLEPTALTIC 511
            ||||:.|||||||..:||.|:||..:|||..|.|.|.:.:.....||||
Mouse   426 FLDYDAGDISFYNMSNGSLIYTFPSISFSGPLRPFFCLWSCGKKPLTIC 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A1	NP_008979.3	IG_like	37..143	CDD:214653	45/105 (43%)
		Ig_MOG_like	45..144	CDD:143190	42/98 (43%)
		SPRY_PRY_BTN3	337..512	CDD:293992	97/175 (55%)
Btn1a1	NP_038511.1	IG_like	36..142	CDD:214653	45/105 (43%)
		Ig	44..143	CDD:299845	42/98 (43%)
		Ig	149..>203	CDD:299845	17/53 (32%)
		SPRY_PRY_BTN1_2	304..474	CDD:293991	95/170 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KB3
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39342
OrthoDB	1	1.010	-	-		D175892at32523
OrthoFinder	1	1.000	-	-		FOG0001727
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830