Protein Alignment CIT and PKH2

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_014541.1
• Gene: PKH2 / 854053
• SGDID: S000005460
• Length: 1081
• Species: Saccharomyces cerevisiae
• Alignment Length: 944
• Identity: 214/944 - (22%)
• Similarity: 371/944 - (39%)
• Gaps: 211/944 - (22%)

Human    68 MKIKHVSNFVRKYSDTIAELQE--LQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKK 130
            :||:|.|:..:..:...::.|:  ::...|||:..|::|.|.::.|.:.....|...||.||:.|
Yeast   148 VKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNK 212

Human   131 KALLAQEQVSFFEEERNILSR-STSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLD 194
            :.|:.|::|.:...|:..|.: :.||.:.:|...|||::.||.::||.|.||.|||:.:| ..||
Yeast   213 EYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKY-GSLD 276

Human   195 ENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMN-SNKMVN----- 253
            |...::|.|::|.|:..:|..|.:||||||||||:|....|||.|||:|..:| :|..|:
Yeast   277 ETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYD 341

Human   254 ----AKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNN 314
                :|..:||.:|::||:|.....|.:      ||.|:.|.|.::||.|:.||.......||..
Yeast   342 LSTRSKSFVGTAEYVSPELLNDSFTDYR------CDIWAFGCILFQMIAGKPPFKATNEYLTFQK 400

Human   315 IMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKE-RLKFEGLCCHPFFSKIDW--NNIRNSPPPFV 376
            :|..| :...|..|.:   ..||::.:|....: ||....:..|.||..:::  .::.:..||.:
Yeast   401 VMKVQ-YAFTPGFPLI---IRDLVKKILVKNLDRRLTISQIKEHHFFKDLNFKDGSVWSKTPPEI 461

Human   377 PTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRS---------- 431
            ...|                :::...|..||| |..:|      ..|::..||:|
Yeast   462 KPYK----------------INAKSMQAMPSG-SDRKL------VKKSVNTLGKSHLVTQRSASS 503

Human   432 --------------------ESVVS-------------------GLD-----------SPAKTSS 446
                                ||.:|                   |::           |.|.:::
Yeast   504 PSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQILENARKGINNRKNQPGKRTPSGAASAA 568

Human   447 MEKKLLIKSKELQD---SQDKCHKMEQEMTR----LHRRVSEVEAVLSQKEVELKASETQRSL-- 502
            :.....:..|.:|.   |..|..:.....|.    .::|.|..|:....|...|.||.....:
Yeast   569 LAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSSTESKPFAKSPPLSASVLSSKVPM 633

Human   503 ------LEQDLATYITECSSLKRSLEQ---------------ARMEVSQEDDKALQLLHDIREQS 546
                  :...:..|.|...:...:.:|               ::..|....|..|....|| :.|
Yeast   634 PPYTPPMSPPMTPYDTYQMTPPYTTKQQDYSDTAIAAPKPCISKQNVKNSTDSPLMNKQDI-QWS 697

Human   547 RKLQEIKEQEYQAQ-----------VEEMRLMMN--QLEEDLVSARRRSDLYESELRESRLAAEE 598
            ..|:.|.|...:.:           :|:..|.:|  .|:..|....|.:.|  |::..|......
Yeast   698 FYLKNINEHVLRTEKLDFVTTNYDILEKKMLKLNGSLLDPQLFGKPRHTFL--SQVARSGGEVTG 760

Human   599 FKRKATECQHKLLKAKDQGKPEVGEYAK----LEKINAEQQLKIQELQEKLEKAVKASTEATELL 659
            |:...|...:        .|.|...|:|    |:.:..:.:::..:|.|.|   ...|.|..:..
Yeast   761 FRNDPTMTAY--------SKTEDTYYSKNIIDLQLLEDDYRIEGGDLSELL---TNRSGEGYKCN 814

Human   660 QNIRQAKERAERELEKLQNREDSS--EGIRKKL---VEAEERRHSLENKVKR------------- 706
            ||....|:..:.|    .|.:.||  .|..|||   ..|.|...|.:.|.|.
Yeast   815 QNSSPMKDDDKSE----SNNKGSSVFSGKIKKLFHPTSAAETLSSSDEKTKYYKRTIVMTSFGRF 875

Human   707 LETMERRE--------NRLKDDIQTKSQQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 763
            |...:||:        ..|:.||..: ||..::.:.|:.||.......|.....:..|...::..
Yeast   876 LVFAKRRQPNPVTNLKYELEYDINLR-QQGTKIKELIIPLEMGTNHIVVIQTPYKSFLLSTDKKT 939

Human   764 EEKI-----KVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI 823
            ..|:     |:|::...|  .:||.|:...:..|......|:.:.:......:...|.|:..|.
Yeast   940 TSKLFTVLKKILNSNTNK--IEKELLQRNQKVIERRTSSSGRAIPKDLPTSKSPSPKPRTHSQS- 1001

Human   824 VELSEANKLAAN-SSLFTQRNMKAQEEMISELRQ 856
            ..:|:.|..:.: :|..:.|:.:..|..|:...|
Yeast  1002 PSISKHNSFSESINSAKSNRSSRIFETFINAKEQ 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	106/340 (31%)
		CwlO1	442..>598	CDD:443091	34/198 (17%)
		SMC_prok_B	531..1343	CDD:274008	77/375 (21%)
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
PKH2	NP_014541.1	STKc_PDK1	177..443	CDD:270733	95/276 (34%)