DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CIT and YPK1

DIOPT Version :9

Sequence 1:	XP_011536085.1	Gene:	CIT / 11113	HGNCID:	1985	Length:	2084	Species:	Homo sapiens
Sequence 2:	NP_012796.1	Gene:	YPK1 / 853733	SGDID:	S000001609	Length:	680	Species:	Saccharomyces cerevisiae

Alignment Length:	352	Identity:	121/352 - (34%)
Similarity:	189/352 - (53%)	Gaps:	29/352 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    93 SAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWI 157
            |..||::..::|.|.|.:|..||:|.|..:||:|.::|..::::.:|:....||.:|:|...|:|
Yeast   343 SIDDFDLLKVIGKGSFGKVMQVRKKDTQKVYALKAIRKSYIVSKSEVTHTLAERTVLARVDCPFI 407

Human   158 PQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDI 222
            ..|:::||....||.|:.:..||:|...|.: |.:.|.:..:||.|||:.|:.::|.:..|:||:
Yeast   408 VPLKFSFQSPEKLYFVLAFINGGELFYHLQK-EGRFDLSRARFYTAELLCALDNLHKLDVVYRDL 471

Human   223 KPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWW 287
            ||||||:|..|||.|.||| ..|:|...........|||:|:|||:|.     |.| |....|||
Yeast   472 KPENILLDYQGHIALCDFG-LCKLNMKDDDKTDTFCGTPEYLAPELLL-----GLG-YTKAVDWW 529

Human   288 SVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLC-GQKERLKF 351
            ::||:.|||:.|..|:.:....:.:..|:  |..|.|||.  ...|..||:..||. ....||.:
Yeast   530 TLGVLLYEMLTGLPPYYDEDVPKMYKKIL--QEPLVFPDG--FDRDAKDLLIGLLSRDPTRRLGY 590

Human   352 EG---LCCHPFFSKIDWNNI--RNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSG 411
            .|   :..|||||::.|..:  :...||:.|.:.:..|||||||    .:....|.......:..
Yeast   591 NGADEIRNHPFFSQLSWKRLLMKGYIPPYKPAVSNSMDTSNFDE----EFTREKPIDSVVDEYLS 651

Human   412 EEL--PFVGFSY--SKALG---ILGRS 431
            |.:  .|.|::|  ::.||   :.|||
Yeast   652 ESVQKQFGGWTYVGNEQLGSSMVQGRS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	115/336 (34%)
		S_TKc	97..360	CDD:214567	95/266 (36%)
		Smc	474..1335	CDD:224117
		C1	1405..1453	CDD:237996
		PH	1486..1605	CDD:278594
		CNH	1650..1946	CDD:214481
YPK1	NP_012796.1	YPK1_N_like	116..342	CDD:212165
YPK1	NP_012796.1	PKc_like	352..663	CDD:419665	112/326 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910