Protein Alignment CIT and TPK1

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_012371.2
• Gene: TPK1 / 853275
• SGDID: S000003700
• Length: 397
• Species: Saccharomyces cerevisiae
• Alignment Length: 348
• Identity: 121/348 - (34%)
• Similarity: 193/348 - (55%)
• Gaps: 34/348 - (9%)

Human    60 EECSQPALMKIKHVSNF-VRKYSDTIAELQEL--QPSAKDFEVRSLVGCGHFAEVQVVREKATGD 121
            |:..||      ||:.: ..:|...||:.:..  :.|.:||::...:|.|.|..|.::|.:..|.
Yeast    53 EKPKQP------HVTYYNEEQYKQFIAQARVTSGKYSLQDFQILRTLGTGSFGRVHLIRSRHNGR 111

Human   122 IYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLL 186
            .|||||:||:.::..:||....:||.:||..|.|:|.::...|||...::::|:|..||:|.|||
Yeast   112 YYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLL 176

Human   187 NRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKM 251
             |...:....:.:||.||:.||:..:|....::||:||||||:|:.||||:.|||.|..:..
Yeast   177 -RKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--- 237

Human   252 VNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIM 316
            |...| .|||||:||||::..      .|....||||.|::.|||:.|.:||.:..:.:|:..|:
Yeast   238 VTYTL-CGTPDYIAPEVVSTK------PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKIL 295

Human   317 NFQRFLKFPDDPKVSSDFLDLIQSLLCGQ-KERL-----KFEGLCCHPFFSKIDWNNI--RNSPP 373
            |.:  |:||  |..:.|..||:..|:... .:||     ..|.:..||:|.::.|..:  ||...
Yeast   296 NAE--LRFP--PFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIET 356

Human   374 PFVPTL-KSDDDTSNFDE-PEKN 394
            |:.|.: :...|||.||: ||::
Yeast   357 PYEPPIQQGQGDTSQFDKYPEED 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	112/310 (36%)
		CwlO1	442..>598	CDD:443091
		SMC_prok_B	531..1343	CDD:274008
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
TPK1	NP_012371.2	STKc_PKA_like	85..375	CDD:270732	110/304 (36%)