Protein Alignment CIT and DBF2

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_011606.3
• Gene: DBF2 / 852984
• SGDID: S000003324
• Length: 572
• Species: Saccharomyces cerevisiae
• Alignment Length: 474
• Identity: 145/474 - (30%)
• Similarity: 228/474 - (48%)
• Gaps: 86/474 - (18%)

Human    20 IASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTI 84
            :.||..|.....:    ::.||...|.|.:      ..|.||.|  :.::.:|  ..:||
Yeast   122 VISRRQRTKQVLE----YLQQQSQLPNSDQ------IKLNEEWS--SYLQREH--QVLRK----- 167

Human    85 AELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNIL 149
               :.|:|..:|||:.:.||.|.:.:|.:.|:|.|.::.|:|::.||.|....:......||:||
Yeast   168 ---RRLKPKNRDFEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDIL 229

Human   150 SRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHL 214
            :.:.|.|:.:|.|||||...|||.||:.||||..:||.... .|.....:||::|:..||:::|.
Yeast   230 TTTRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTR-CLKSGHARFYISEMFCAVNALHD 293

Human   215 MGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSN------------------------------ 249
            :||.|||:||||.|:|..|||||.|||.||...||
Yeast   294 LGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISNERIESMKIRLEKIKDLEFPAFTEKSIEDRR 358

Human   250 KMVN---------AKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAE 305
            ||.|         |...:|:|||||.|||     :|| .|....|:||:|.:.:|.:.|.:||:.
Yeast   359 KMYNQLREKEINYANSMVGSPDYMALEVL-----EGK-KYDFTVDYWSLGCMLFESLVGYTPFSG 417

Human   306 GTSARTFNNIMNFQRFLKFP---DDPKVSSD-FLDLIQSLLCGQKERLK-FEGLCCHPFFSKIDW 365
            .::..|::|:..:::.|:.|   |.....|| ..|||..|:.....||: ||.:....:|:.|::
Yeast   418 SSTNETYDNLRRWKQTLRRPRQSDGRAAFSDRTWDLITRLIADPINRLRSFEHVKRMSYFADINF 482

Human   366 NNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVS----------SSPCQLSPSGFSGEELPFVGFS 420
            :.:|:..|||.|.|.|:.|...||:....:.::          .....:..|..|.:   .|||:
Yeast   483 STLRSMIPPFTPQLDSETDAGYFDDFTSEADMAKYADVFKRQDKLTAMVDDSAVSSK---LVGFT 544

Human   421 YSKALGILGRSESVVSGLD 439
            :....|..|.|..:.:||:
Yeast   545 FRHRNGKQGSSGILFNGLE 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	124/380 (33%)
		CwlO1	442..>598	CDD:443091
		SMC_prok_B	531..1343	CDD:274008
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
DBF2	NP_011606.3	MobB_Sid2p-like	85..172	CDD:439271	15/71 (21%)
		STKc_Sid2p_like	165..547	CDD:270751	128/399 (32%)