Protein Alignment CIT and PKH1

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_010778.3
• Gene: PKH1 / 852101
• SGDID: S000002898
• Length: 766
• Species: Saccharomyces cerevisiae
• Alignment Length: 674
• Identity: 164/674 - (24%)
• Similarity: 298/674 - (44%)
• Gaps: 123/674 - (18%)

Human    95 KDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSR-STSPWIP 158
            |||:....:|.|.::.|.:...:.:|..||:||:.|:.|:.|::|.:...|:..|.: :.:..|.
Yeast   123 KDFKFGEQLGDGSYSSVVLATARDSGKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKLNGTKGIF 187

Human   159 QLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIK 223
            :|.:.|||:..||.::||.|.||.|.|:.:| ..|:|...::|.:::|.||.|:|.:|.:|||||
Yeast   188 KLFFTFQDEASLYFLLEYAPHGDFLGLIKKY-GSLNETCARYYASQIIDAVDSLHNIGIIHRDIK 251

Human   224 PENILVDRTGHIKLVDFGSA------------AKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDG 276
            |||||:|:...:||.|||:|            .|...:....:|..:||.:|::||:|.....|.
Yeast   252 PENILLDKNMKVKLTDFGTAKILPEEPSNTADGKPYFDLYAKSKSFVGTAEYVSPELLNDNYTDS 316

Human   277 KGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLK--FPDDPKVSSDFLDLIQ 339
            :      ||.|:.|.|.|:|:.|:.||.......||..:|..|....  ||...|      ||::
Yeast   317 R------CDIWAFGCILYQMLAGKPPFKAANEYLTFQKVMKIQYAFTAGFPQIVK------DLVK 369

Human   340 SLLC-GQKERLKFEGLCCHPFFSKIDW--NNIRNSPPPFVPTLKSDDDTSNFDEP-----EKNSW 396
            .||. ...:||..:.:..|.||.::::  .::.:..||.:...|.:.:..   :|     |.::.
Yeast   370 KLLVRDPNDRLTIKQIKAHLFFHEVNFEDGSVWDDNPPEIQPYKINAEAM---KPLQKVSESDTT 431

Human   397 VSSSPCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLL----IKSKE 457
            |..:..||:.:|.:...|        :|.....:..||:|   ..|.|::..|...    :.||.
Yeast   432 VKMANLQLAGNGHADTPL--------QAPAATSQEHSVIS---MTAATAAFNKDYTSQPKLGSKS 485

Human   458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ---------KEVELKASET----------QRSLL 503
            ....:...:..::|:  :.::||:..|.:|.         |:...::|:.          :|.||
Yeast   486 STSVRSASNNTDREV--IQKKVSKNRASVSSPSISTTSRGKDNRSRSSDAFWSRYLQNMDERVLL 548

Human   504 EQDLATYITECSSLKRSLEQARMEVSQEDD------------KALQLLHDIRE-----QSRKLQE 551
            .:::|............||...::.....|            |.:.|:.::..     :.|.|..
Yeast   549 MKEVALSTRNLEDSPVGLENVALDYKNPLDIEPPTDSAGKFYKKMFLITNLGRALVFVKRRSLSM 613

Human   552 IKEQEYQAQ-------VEEMRLMMNQ-LEED-----LVSARRRSDLYES-ELRESRLAAEEFKRK 602
            .:|||::.|       ||::|.:.:| ||.|     .:..:.|:.|.:. :|..:.:.|:. |..
Yeast   614 WEEQEFELQFELELNDVEKIRFISDQVLEIDGSRTIFIGCKERAVLMKLWKLIHNGMTAKP-KVV 677

Human   603 ATECQHKLL-----------KAKDQGKPEVGEYAKLEKINAEQQLKIQE---LQEKLEKAV--KA 651
            :.:..||:.           |.|:|..|.......:..:.....||..|   |..|...::  ::
Yeast   678 SPKSDHKMFDKFILQKRQNTKKKNQAPPVPQSNRLINGLPDRCILKTPEEGALHTKRPTSLQTRS 742

Human   652 STEATELLQNIRQAKERAERELEK 675
            |:..::||....|.::...|..||
Yeast   743 SSNYSKLLARSTQMRKNMTRTDEK 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	103/349 (30%)
		CwlO1	442..>598	CDD:443091	38/209 (18%)
		SMC_prok_B	531..1343	CDD:274008	39/192 (20%)
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
PKH1	NP_010778.3	STKc_PDK1	123..391	CDD:270733	91/280 (33%)