Protein Alignment CIT and PKH3

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_010754.1
• Gene: PKH3 / 852077
• SGDID: S000002874
• Length: 898
• Species: Saccharomyces cerevisiae
• Alignment Length: 737
• Identity: 177/737 - (24%)
• Similarity: 313/737 - (42%)
• Gaps: 161/737 - (21%)

Human    93 SAKDFEVRSLVGCGHFAEV-QVVREKATGDIYAMKVMKKKALLAQEQVSFFEEER---NILSRST 153
            |..||..:..:|.|.::.| :.:.:|:...|||:||..||.::.:.:|.:...|:   |:|::..
Yeast     7 SPHDFIFKEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKH 71

Human   154 SPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYV 218
            ...|.:|.|.|.|:.:||.|:::.|||:|||||::. ...::...:.:.|:||.|:..:|..|.:
Yeast    72 HAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKM-GTFNDIWTRHFTAQLIDALEFIHSHGII 135

Human   219 HRDIKPENILVDRTGHIKLVDFGSA-----------AKMNSNK-----MVNAKLPIGTPDYMAPE 267
            |||:||||:|:||.|.:.:.|||:|           ||.||:.     ..|....:||.:|::||
Yeast   136 HRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKFNSDSNGSKDNQNCASFVGTAEYVSPE 200

Human   268 VLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPK--- 329
            :| :.|..|.|:     |.|::|.:.|:.:.|:.||......:||..|:    .|.:|..|.
Yeast   201 LL-LYNQCGYGS-----DIWALGCMIYQFVQGQPPFRGENELKTFEKIV----ALDYPWGPNNRI 255

Human   330 ------VSSDFLDLIQSLLCGQ-KERLKFEGLCCHPFFSKIDWNN-------------------- 367
                  ::...::|:|.:|..: .||:..|.:..||:|||:|||:
Yeast   256 NNSTSPINPLVINLVQKILVIEVNERISLEQIKRHPYFSKVDWNDKIKIWRGIWQSQGQSLQQTT 320

Human   368 --IRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFSYSKALGI--- 427
              :.|.|...:||.:    ....|.|.::..::... :..|:..|......|  .:.|.|||
Yeast   321 LGLPNIPQNILPTRQ----LHVIDTPARSIQITKQK-RKKPTKISNTTSSIV--VWRKRLGISTG 378

Human   428 ---LGRSESVVSGLDSPAKTSSMEKKLLIKSKEL---QDSQDKCHKMEQEM--TRLHRRVSEVEA 484
               ||...|....:.:|..|:.:.......:..:   .:||....|..|.:  .|:..:|..:..
Yeast   379 KDDLGTVPSTTPAVTAPNDTNVLTNTAAHSTANIALPPNSQSNQVKRAQLVAPNRIPPKVPVIND 443

Human   485 VLSQKEV---ELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDI-REQ 545
            .:..|.:   :......|.|.:.|.|:|     ||...:|.....|:..:|     |.|.: ...
Yeast   444 NVRNKSIPRTKPNVPPLQTSSIPQKLST-----SSASSALSAPSTEIRNQD-----LTHTLDGRN 498

Human   546 SRKLQEIKEQ-------EYQAQVEEMRL-MMNQLEEDLVS---ARRRSDLYESELRESRLAAEEF 599
            |..:..:|:.       .|:.:...|.| ..|:::.||::   |:.:.:|..|   ||.|.....
Yeast   499 SIDIHVLKQDYVFIYGIPYEHEGPAMSLNSYNKIDNDLITSLVAQHKEELKNS---ESFLQVLTL 560

Human   600 KRKA-TECQHKLLKAKDQGKPEVGEYAKLEKINAEQ-QLKIQELQEK----LEK----------- 647
            |:.. ...::.:::..|..:.:..:.|.:|..:... ..:..||..|    |||
Yeast   561 KKSGMLSYKNTVMEGNDDQENKEHQMANIEDTDLSMYDFEFNELTRKGFLILEKYKNRIWFISLP 625

Human   648 -----------AVKAST------------EATELLQNIRQAKERAERELEKLQN----REDSSEG 685
                       |||:||            .|.:||:.        ::.|:|:.|    .:.|||.
Yeast   626 SYSTLSKIPFNAVKSSTINNNENWVDCFFRARQLLEE--------KQILDKISNVSFDSKASSEP 682

Human   686 IRKKLVEAEERRHSLENKVKRL 707
            .....:..:||..|:.|.|..|
Yeast   683 SSPPPISRKERPLSIGNNVTTL 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	104/378 (28%)
		CwlO1	442..>598	CDD:443091	34/175 (19%)
		SMC_prok_B	531..1343	CDD:274008	47/233 (20%)
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
PKH3	NP_010754.1	STKc_PDK1	9..293	CDD:270733	89/294 (30%)