Protein Alignment CIT and KIN82

DIOPT Version :10

• Sequence 1: XP_011536085.1
• Gene: CIT / 11113
• HGNCID: 1985
• Length: 2084
• Species: Homo sapiens
• Sequence 2: NP_010015.3
• Gene: KIN82 / 850453
• SGDID: S000000687
• Length: 720
• Species: Saccharomyces cerevisiae
• Alignment Length: 519
• Identity: 142/519 - (27%)
• Similarity: 238/519 - (45%)
• Gaps: 101/519 - (19%)

Human    15 GAAEPIASRASRLNLFFQGKP--------------------PFMTQQQMSPL--SREGILDALFV 57
            |:|.|:|      ||.....|                    |.:.:....|.  :::|::...::
Yeast   227 GSASPLA------NLSLSNSPIDSPRKNSETRKDQIPMNITPRLRRAASEPFNTAKDGLMREDYI 285

Human    58 LFE------ECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVRE 116
            ..:      :..:|...:.....:|..|:.|...|.|       .||...|:|.|...:|.:|||
Yeast   286 ALKQPPSLGDIVEPRRSRRLRTKSFGNKFQDITVEPQ-------SFEKIRLLGQGDVGKVYLVRE 343

Human   117 KATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGD 181
            :.|..|:|:||:.|..::.::::.....|:.||:.|..|:|..|.::||.|::|||.|||..||:
Yeast   344 RDTNQIFALKVLNKHEMIKRKKIKRVLTEQEILATSDHPFIVTLYHSFQTKDYLYLCMEYCMGGE 408

Human   182 LL-SLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAK 245
            .. :|..|....:.|...:||.:|::.|:..:||:|:::||:||||||:.::||:.|.||..:.:
Yeast   409 FFRALQTRKSKCIAEEDAKFYASEVVAALEYLHLLGFIYRDLKPENILLHQSGHVMLSDFDLSIQ 473

Human   246 MNSNKMVNAKLP-----------------IGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIA 293
            ...:|....|..                 :||.:|:||||:   .|:|   :....|||::|::.
Yeast   474 ATGSKKPTMKDSTYLDTKICSDGFRTNSFVGTEEYLAPEVI---RGNG---HTAAVDWWTLGILI 532

Human   294 YEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEG----- 353
            |||::|.:||....|..||:||:.  :.:|||.|.:||.:..|||:.||  .|...|..|
Yeast   533 YEMLFGCTPFKGDNSNETFSNILT--KDVKFPHDKEVSKNCKDLIKKLL--NKNEAKRLGSKSGA 593

Human   354 --LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNF-----DEPEKNSWVSSSPCQLSPSGFSG 411
              :..||||.|:.|:.:||..||.:|.|..:.....|     ..|::||..............:.
Yeast   594 ADIKRHPFFKKVQWSFLRNQDPPLIPALNDNGCELPFILSCNKHPKRNSVSEQETKMFCEKVAND 658

Human   412 EEL----PFVGFS----YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHK 467
            :|:    ||..|:    ..|...||..||:...|            |:|.|:...:...:..|:
Yeast   659 DEIDEADPFHDFNSMSLTKKDHNILTYSENYTYG------------KILYKATCTRPRHNSSHR 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	116/364 (32%)
		CwlO1	442..>598	CDD:443091	4/26 (15%)
		SMC_prok_B	531..1343	CDD:274008
		CRIK	1401..1456	CDD:410364
		PH	1486..1605	CDD:459697
		CNH	1650..1946	CDD:214481
KIN82	NP_010015.3	STKc_phototropin_like	322..623	CDD:270726	109/317 (34%)